Steven J. Barrett
GeneGene predictionMachine learningSupport vector machineDisease gene identificationArtificial intelligenceDiseaseBiological networkDisease geneGenomic informationInteraction informationComputer scienceComputational biologyDrug discoveryIdentification (information)Benchmarking
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#1Sergio Picart-Armada (UPC: Polytechnic University of Catalonia)H-Index: 5
#2Steven J. BarrettH-Index: 1
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In-silico identification of potential target genes for disease is an essential aspect of drug target discovery. Recent studies suggest that successful targets can be found through by leveraging genetic, genomic and protein interaction information. Here, we systematically tested the ability of 12 varied algorithms, based on network propagation, to identify genes that have been targeted by any drug, on gene-disease data from 22 common non-cancerous diseases in OpenTargets. We considered two biolog...
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