Susan Hartzell
Icahn School of Medicine at Mount Sinai
Internal medicineDownregulation and upregulationAutocrine signallingPeripheral blood mononuclear cellAntigenCellAntibodyCardiologyCD8ReceptorSGK1ChemistryFollicular phaseAcquired immune systemImmunophenotypingImmunologyVaccinationEx vivoMembranous nephropathyT cellAlbuminuriaImmunoglobulin MCXCR5Administration (government)HypoxemiaSystemic lupus erythematosusPodocyteAutoimmune hepatitisGlomerulosclerosisC3a receptorFluoroSpotRegulatory T cellB cellErythropoietinKidney diseaseCytokinePrednisoneChronic liver diseasePneumococcal vaccineImmunityPneumococcal polysaccharide vaccineKidneyAutoimmunityImmunosuppressionKidney transplantationGlomerulonephritisNephrinImmunoglobulin GRegulatory B cellsT follicular helper cell differentiationTacrolimusCells plasmaANCA-Associated VasculitisActin cytoskeletonIn patientErythropoietin receptorCancer researchFlow cytometryMedicineBiomarker (medicine)Decay-accelerating factorBiologyImmune systemC3-convertaseCell biologyGerminal center
12Publications
4H-index
83Citations
Publications 13
Newest
#1Chiara Guglielmo (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
#2Sofia Bin (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
Last. Peter T. Sage (Brigham and Women's Hospital)H-Index: 24
view all 14 authors...
Background: While high affinity IgG auto- and allo-antibodies are important drivers of kidney inflammation that can result in end stage kidney disease, therapeutic approaches that effectively reduce such pathogenic antibodies remain elusive. Erythropoietin (EPO) has immunomodulatory functions, but its effects on antibody production are unknown. Methods: We assessed the impact and underlying mechanisms of EPO/EPO receptor (EPOR) signaling on primary and secondary, T cell-dependent and T-independe...
1 CitationsSource
#1Susan HartzellH-Index: 4
#2Meredith HaverlyH-Index: 3
Last. Paolo CravediH-Index: 35
view all 6 authors...
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#1Susan HartzellH-Index: 4
#2Luis Sanchez-RussoH-Index: 1
Last. Paolo CravediH-Index: 35
view all 10 authors...
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#1Elisa McEachern (NU: Northwestern University)
#2Allison M. Carroll (NU: Northwestern University)
Last. Josh Levitsky (NU: Northwestern University)H-Index: 47
view all 8 authors...
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#1Elisa McEachern (NU: Northwestern University)
#2Allison M. Carroll (NU: Northwestern University)
Last. Josh Levitsky (NU: Northwestern University)H-Index: 47
view all 8 authors...
Abstract Objective Autoimmune hepatitis (AIH) is a chronic liver disease associated with impaired regulatory T cell (Treg) number and function. Erythropoietin (EPO) is a kidney-produced erythropoietic hormone that has known immune-modulating effects, including Treg induction. Whether EPO administration increases Treg in patients with AIH is unknown. Methods We treated six stable AIH patients with a single 1000 IU dose of EPO and comprehensively characterized changes in Treg overall and in Treg s...
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#1Joaquin ManriqueH-Index: 7
#2Emilie ChanH-Index: 1
Last. Paolo CravediH-Index: 35
view all 13 authors...
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#1Susan HartzellH-Index: 4
#2Sofia Bin (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
Last. Paolo CravediH-Index: 35
view all 13 authors...
Individuals with kidney failure are at increased risk of cardiovascular events, as well as infections and malignancies, but the associated immunological abnormalities are unclear. We hypothesized that the uremic milieu triggers a chronic inflammatory state that, while accelerating atherosclerosis, promotes T cell exhaustion, impairing effective clearance of pathogens and tumor cells. Clinical and demographic data were collected from 78 patients with chronic kidney disease (CKD) (n = 42) or end-s...
3 CitationsSource
#1Andrea Angeletti (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 11
#2Chiara Cantarelli (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 8
Last. Paolo Cravedi (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 35
view all 26 authors...
Kidney glomerulosclerosis commonly progresses to end-stage kidney failure, but pathogenic mechanisms are still poorly understood. Here, we show that podocyte expression of decay-accelerating factor (DAF/CD55), a complement C3 convertase regulator, crucially controls disease in murine models of adriamycin (ADR)-induced focal and segmental glomerulosclerosis (FSGS) and streptozotocin (STZ)-induced diabetic glomerulosclerosis. ADR induces enzymatic cleavage of DAF from podocyte surfaces, leading to...
48 CitationsSource
#1Susan Hartzell (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 4
#2Sofia Bin (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
Last. Paolo Cravedi (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 35
view all 13 authors...
Whether kidney transplant recipients are capable of mounting an effective anti-SARS-CoV-2 adaptive immune response despite chronic immunosuppression is unknown and has important implications for therapy. Herein, we analyzed peripheral blood cell surface and intracellular cytokine phenotyping by flow cytometry along with serum antibody testing in 18 kidney transplant recipients with active COVID-19 infection and 36 matched, transplanted controls without COVID-19. We observed significantly fewer t...
19 CitationsSource
#1Chiara Cantarelli (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 8
#2Marta Jarque (Bellvitge University Hospital)H-Index: 8
Last. Paolo Cravedi (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 35
view all 22 authors...
ABSTRACT Introduction Primary membranous nephropathy (MN) is characterized by the presence of anti-podocyte antibodies, but studies describing phenotypic and functional abnormalities in circulating lymphocytes are limited. Methods We analyzed 68 different B- and T- cell subsets by flow cytometry in 30 MN patients (before initiating immunosuppression) comparing to 31 patients with nonimmune-mediated chronic kidney disease (CKD) and 12 healthy individuals. We also measured 19 serum cytokines in MN...
4 CitationsSource