Yong Yang
Jilin University
Detection limitDownregulation and upregulationGenomeAntigenMolecular biologyVirologyAntibodyCD8ReceptorChemistryDNA methylationReference genomeImmunologyAutophagyVaccinationColitisClonorchiasisT cellInflammationTrichinellaSerine proteaseInflammatory bowel diseaseRegulatory T cellCytokineNematodeImmunityClonorchis sinensisSpleenTrichinella spiralisPopulationHelminth geneticsCD40Recombinant DNAChromatographyGeneticsFlow cytometryGene familyMedicineParasite hostingBiologyImmune systemMicrobiologyCell biology
29Publications
9H-index
171Citations
Publications 26
Newest
#1Yao Yu (JLU: Jilin University)H-Index: 1
#2Yan-Song Li (JLU: Jilin University)H-Index: 19
Last. Yu Zhou (JLU: Jilin University)H-Index: 19
view all 8 authors...
Abstract null null Fumonisin B1 (FB1) is one of the most toxic and widely distributed subtypes of the 20 fumonisins, which has attracted much attention in food and feed safety. In this study, a convenient colorimetric immunoassay was proposed for the detection of FB1 based on Mn2+-mediated aggregation of gold nanoparticles (AuNPs). After hydrolyzing of ascorbic acid 2-phosphate (AAP) by alkaline phosphatase (ALP), the generated ascorbic acid (AA) decomposes brown MnO2 shell to Mn2+, which growth...
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#1Xuemin Jin (JLU: Jilin University)H-Index: 3
#2Yong Yang (JLU: Jilin University)H-Index: 9
Last. Mingyuan Liu (JLU: Jilin University)H-Index: 23
view all 12 authors...
Abstract The inflammasome is a key line of immune defense against invading infectious pathogens. However, knowledge of the role of nod-like receptor pyrin domain containing 3 (NLRP3) in Trichinella spiralis infection which characteristically induces T-helper 2 (Th2) immune responses is sparse. In this study, we investigated the role of NLRP3 in the protection against T. spiralis infection through the Th2 immune response. We show that NLRP3 expression in CD4+ T cells was significantly increased a...
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#1Daoxiu Xu (JLU: Jilin University)H-Index: 2
#2Bin Tang (JLU: Jilin University)H-Index: 10
Last. Xiaolei Liu (JLU: Jilin University)H-Index: 16
view all 11 authors...
Abstract Trichinellosis caused by Trichinella spiralis (T. spiralis) is an important public health problem. DNase II is an acidic endonuclease that catalyzes the degradation of DNA into oligonucleotides. DNase II-7 has been detected at the adult stage of T. spiralis and has been examined in excretory/secretory products. Previous studies have indicated that the DNase II-7 recombinant protein has a high rate of protection against T. spiralis infection in mice. In the present study, the protective ...
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The physical barrier is composed of epithelial cells which are joined together through intercellular connections. It serves to prevent pathogenic microorganisms from departing the intestinal lumen to invade host. The excretory secretory (ES) products of Trichinella spiralis are critical for invasion. However, whether ES products of T. spiralis can act on the intestinal barrier is still unknown. In this study, the role of ES products of T. spiralis muscle larvae (Ts-ML-ES) in host invasion was st...
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#1Xiaoxiang Hu (JLU: Jilin University)H-Index: 1
#2Xiaolei Liu (JLU: Jilin University)H-Index: 16
Last. Mingyuan Liu (JLU: Jilin University)H-Index: 23
view all 11 authors...
Trichinella spiralis (T. spiralis) is a widely distributed pathogenic microorganism that causes trichinellosis, a disease that has the potential of causing severe harm to their host. Numerous studies have demonstrated that autophagy can be triggered by microbial infection, such as bacteria, viruses, protozoa, and parasitic helminths. However, it's still unknown whether autophagy can facilitate host resistance to T. spiralis infection. The present study examined the role of autophagy in striated ...
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#1Nan Wang (JLU: Jilin University)H-Index: 2
#2Xue Bai (JLU: Jilin University)H-Index: 14
Last. Xiaolei Liu (JLU: Jilin University)H-Index: 16
view all 11 authors...
Clonorchiasis is a zoonotic disease that can result in chronic infection in humans. The causative agent, Clonorchis sinensis (C. sinensis), is believed to primarily induce a Th2 immune response in infected mice. However, few studies have profiled host immune responses to C. sinensis infection during the juvenile phase. In the present study, the dynamics of select cellular responses and cytokine expression profiles during juvenile C. sinensis infection were investigated. The flow cytometry result...
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#1Xiaolei Liu (JLU: Jilin University)H-Index: 16
#2Yayan FengH-Index: 1
Last. Fei Gao (UCPH: University of Copenhagen)H-Index: 16
view all 10 authors...
Genome assemblies provide a powerful basis of comparative multi-omics analyses that offer insight into parasite pathogenicity, host-parasite interactions, and invasion biology. As a unique intracellular nematode, Trichinella consists of two clades, encapsulated and non-encapsulated. Genomic correlation of the distinct differences between the two clades is still unclear. Here, we report an annotated draft reference genome of non-encapsulated Trichinella, T. pseudospiralis, and perform comparative...
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#1Xin Gao (JLU: Jilin University)H-Index: 2
#2Yong Yang (JLU: Jilin University)H-Index: 9
Last. Xue Bai (JLU: Jilin University)H-Index: 14
view all 8 authors...
Abstract Extracellular vesicles (EVs) are membranous containers released by cells that are powerful agents of intercellular communication. EVs have been described for various parasites and are associated with tissue inflammation. Several studies have demonstrated that parasite EVs can have either pro- or anti-inflammatory impacts, depending on the type of parasite. To evaluate the immunomodulatory properties of EVs produced by Trichinella spiralis (T. spiralis), we established a mouse model with...
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#1Xuemin Jin (JLU: Jilin University)H-Index: 4
#2Xiaolei Liu (JLU: Jilin University)H-Index: 16
Last. Mingyuan Liu (JLU: Jilin University)H-Index: 23
view all 8 authors...
There is an urgent need for the development of new, improved vaccine adjuvants against T. spiralis infection. Polysaccharides are effective, safe, and biodegradable as adjuvant. In our study, we first observed the protective efficacy of lentinan as adjuvant against helminth T. spiralis infection. Recombinant T. spiralis Serpin (rTs-Serpin) immunoscreened from a cDNA library of T. spiralis, as a vaccine, protect host against Trichinella infection. The reduction rate of helminth burden of rTs-Serp...
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#1Xuemin Jin (JLU: Jilin University)H-Index: 3
#2Xue Bai (JLU: Jilin University)H-Index: 14
Last. Xiaolei Liu (JLU: Jilin University)H-Index: 16
view all 9 authors...
Trichinella spiralis maintains chronic infections within its host. Muscle larvae excretory-secretory products (MLES) typically induce parasite-specific immune responses such as the Th2 response and regulatory T cells (Tregs) by modulating dendritic cell (DC) phenotype via the recognition of pattern recognition receptors (PRRs), such as Nod-like receptors (NLRs). We aimed to investigate the role of NLRP3 in T. spiralis-triggered immune response. We found that larvae burden was increased in NLRP3-...
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