Mara Gilardi
University of California, San Diego
CancerBone cellPathologyCellular differentiationCellBone remodelingChemistryMesenchymal stem cellIn vivoOsteoclastHead and neck squamous-cell carcinomaEndotheliumImmunotherapyOsteoblastMetastasisExtravasationSkeletal muscleFibrosisAnti ctla 4Cancer researchMedicinePI3K/AKT/mTOR pathwayBiologyCell biologyCancer cell
31Publications
11H-index
664Citations
Publications 30
Newest
#1Zhiyong Wang (UCSD: University of California, San Diego)H-Index: 51
#2Yusuke Goto (UCSD: University of California, San Diego)H-Index: 5
Last. J. Silvio Gutkind (UCSD: University of California, San Diego)H-Index: 119
view all 15 authors...
Immune checkpoint blockade (ICB) therapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, but <20% of patients achieve durable responses. Persistent activation of the PI3K/AKT/mTOR signaling circuitry represents a key oncogenic driver in HNSCC; however, the potential immunosuppressive effects of PI3K/AKT/mTOR inhibitors may limit the benefit of their combination with ICB. Here we employ an unbiased kinome-wide siRNA screen to reveal that HER3, is essential for the prol...
Source
#1Francis BurrowsH-Index: 29
#2M. ShivaniH-Index: 1
Last. S. GutkindH-Index: 1
view all 6 authors...
1 CitationsSource
#1Shuling Ren (UCSD: University of California, San Diego)H-Index: 7
#2Daria A. Gaykalova (Johns Hopkins University)H-Index: 23
Last. Joseph A. Califano (UCSD: University of California, San Diego)H-Index: 88
view all 23 authors...
The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype with increase in expression of E2/E4/E5, as well as association with lack of integration into the host genome. Models of the E2/E4/E5 carcinogenesis show p53 dependent enhanced prolif...
5 CitationsSource
#1Mara Gilardi (UCSD: University of California, San Diego)H-Index: 11
#2Zhiyong Wang (UCSD: University of California, San Diego)H-Index: 51
Last. Francis BurrowsH-Index: 29
view all 14 authors...
Tipifarnib is a potent and highly selective inhibitor of farnesyltransferase (FT). FT catalyzes the post-translational attachment of farnesyl groups to signaling proteins that are required for localization to cell membranes. Although all RAS isoforms are FT substrates, only HRAS is exclusively dependent upon farnesylation, raising the possibility that HRAS mutant tumors might be susceptible to tipifarnib-mediated inhibition of FT. Here, we report the characterization of tipifarnib activity in a ...
8 CitationsSource
#1Zhiyong WangH-Index: 51
Last. J. Silvio GutkindH-Index: 119
view all 9 authors...
Source
#1Dina V. Hingorani (UCSD: University of California, San Diego)H-Index: 7
#2Jessica L. Crisp (UCSD: University of California, San Diego)H-Index: 13
Last. Sunil J. Advani (UCSD: University of California, San Diego)H-Index: 27
view all 15 authors...
Abstract Patients with advanced cancers are treated with combined radiotherapy and chemotherapy, however curability is poor and treatment side effects severe. Drugs sensitizing tumors to radiotherapy have been developed to improve cell kill, but tumor specificity remains challenging. To achieve tumor selectivity of small molecule radiosensitizers, we tested as a strategy active tumor targeting using peptide-based drug conjugates. We attached an inhibitor of the DNA damage response to antibody or...
4 CitationsSource
#1Yusuke Goto (UCSD: University of California, San Diego)H-Index: 5
#2Toshinori Ando (UCSD: University of California, San Diego)H-Index: 9
Last. J. Silvio Gutkind (UCSD: University of California, San Diego)H-Index: 119
view all 9 authors...
Prostate cancer (PCa) innervation contributes to the progression of PCa. However, the precise impact of innervation on PCa cells is still poorly understood. By focusing on muscarinic receptors, which are activated by the nerve-derived neurotransmitter acetylcholine, we show that muscarinic receptors 1 and 3 (m1 and m3) are highly expressed in PCa clinical specimens compared with all other cancer types, and that amplification or gain of their corresponding encoding genes (CHRM1 and CHRM3, respect...
8 CitationsSource
#1Sudeep Banerjee (UCSD: University of California, San Diego)H-Index: 5
#1Sudeep Banerjee (UCSD: University of California, San Diego)
Last. Partha Ray (UCSD: University of California, San Diego)H-Index: 14
view all 9 authors...
Gastrointestinal stromal tumor (GIST), the most common sarcoma, is characterized by KIT protein overexpression, and tumors are frequently driven by oncogenic KIT mutations. Targeted inhibition of KIT revolutionized GIST therapy and ushered in the era of precision medicine for the treatment of solid malignancies. Here, we present the first use of a KIT-specific DNA aptamer for targeted labeling of GIST. We found that an anti-KIT DNA aptamer bound cells in a KIT-dependent manner and was highly spe...
4 CitationsSource
#1Zhiyong WangH-Index: 51
#2Victoria WuH-Index: 8
Last. J. Silvio GutkindH-Index: 119
view all 19 authors...
Source
#1Zhiyong Wang (UCSD: University of California, San Diego)H-Index: 51
#2Victoria Wu (UCSD: University of California, San Diego)H-Index: 8
Last. J. Silvio Gutkind (UCSD: University of California, San Diego)H-Index: 119
view all 19 authors...
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated HNSCCs have poor prognosis and response to available treatments. Recently approved anti-PD-1 immune checkpoint inhibitors showed limited activity (≤20%) in HNSCC, highlighting the need to identify new therapeutic options. For this, mouse models that accurately mimic the complexity of the HNSCC mutational landscape and tumor immune environm...
23 CitationsSource