Ruihua Li
Jilin University
CytotoxicityCancerASK1Unfolded protein responseMolecular biologyEndoplasmic reticulumProinflammatory cytokineAndrologyFloraTumor necrosis factor alphaChemistryApoptosisSuperoxide dismutaseSOD2Oxidative stressKEAP1ResveratrolInflammationZearalenoneCurcuminMalondialdehydeLipopolysaccharideATF6Cell damageZinc protoporphyrinBeneficial bacteriaDietary fibreWeaned pigletsProgrammed cell deathFood sciencePomaceAflatoxinReactive oxygen speciesCancer researchNecrosisViability assayGlutathioneFlow cytometryWineHsp70IntracellularBiologyMicrobiologyCell biologyCancer cell
7Publications
4H-index
30Citations
Publications 7
Newest
#1Ruihua LiH-Index: 4
#2Hengtong FangH-Index: 4
Last. Jing ZhangH-Index: 5
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Lipopolysaccharide (LPS) is an endotoxin, which may cause immune response and inflammation of bovine mammary glands. Mastitis impairs animal health and results in economic loss. Curcumin (CUR) is a naturally occurring diketone compound, which has attracted widespread attention as a potential anti-inflammatory antioxidant. The purpose of this study is to investigate whether CUR can reduce the damage of bovine mammary epithelial cells (MAC-T) induced by LPS and its underlying molecular mechanism. ...
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#1Ruihua LiH-Index: 4
#2Jing ZhangH-Index: 5
Last. Hao YuH-Index: 8
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Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for cancer treatment. Curcumin (CUR), a well-known cancer inhibitor, significantly inhibits the viability of breast cancer cells. Through transcriptomic analysis and flow cytometry experiments, it was found that after 48 hours of treatment of breast cancer cells at its half maximal inhibitory concentration (IC50), curcumin suppressed the viability of cancer cells via induction of ferroptotic death. Use of the ...
3 CitationsSource
#1Rui Wang (JLU: Jilin University)H-Index: 4
#2Hao Yu (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
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Grape pomace (GP) is an abundant by-product from wine production and is rich in phenolic compounds, unsaturated fatty acids, dietary fibre and beneficial bacteria. In this study, weaned piglets were fed a basic diet supplemented with 5% GP for 4 weeks. Compared with those in the control (CON) group, it was found that the proportion of Lactobacillus delbrueckii, Olsenella umbonata and Selenomonas bovis in the caecum and the villus height and villus height/crypt depth ratio (VCR) of the jejunum we...
1 CitationsSource
#1Jing ZhangH-Index: 5
#2Xin WangH-Index: 4
Last. Hao YuH-Index: 8
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1 CitationsSource
#1Yurong Fu (JLU: Jilin University)H-Index: 4
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
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ABSTRACT Zearalenone (ZEA) is a common mycotoxin produced by fungi within the genus Fusarium. However, few studies have examined the direct effects of the toxin on the mammary glands. In the present study, the effects of ZEA treatment on bovine mammary epithelial cells (MAC-T) from dairy cows were investigated. The cells were treated with different concentrations of ZEA to evaluate the effect of the toxin on cell viability, intracellular reactive oxygen species (ROS) concentrations, mitochondria...
5 CitationsSource
#1Junmei Wang (JLU: Jilin University)H-Index: 4
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
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Deoxynivalenol (DON) is a toxic secondary metabolite produced by Fusarium graminearum. It is one of the most common feed contaminants that poses a serious threat to the health and performance of dairy cows. This study investigated the in vitro cytotoxicity of DON on bovine mammary epithelial cells (MAC-T). DON at different concentrations (0.25, 0.3, 0.5, 0.8, 1 or 2 μg/ml) inhibited the growth of MAC-T cells after 24 hr of exposure (p < .001). DON at 0.25 μg/ml increased lactate dehydrogenase (L...
7 CitationsSource
#1Yongfeng Zhou (JLU: Jilin University)H-Index: 5
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
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Abstract Aflatoxins are widely occurring food contaminants that are particularly harmful to dairy products and cows. The plant polyphenol resveratrol has been reported to have a good effect on increasing the resistance of cells toward toxins. Therefore, we measured the effects of aflatoxin B1 and resveratrol on the viability of the MAC-T cow mammary epithelial cell line. The appropriate treatment concentrations were assayed (12.81 μM aflatoxin B1 and 43.81 μM resveratrol) to verify the protectiv...
11 CitationsSource