Laila A. Gharzai
University of Michigan
SwallowingCancerInternal medicineRadiologyUrologySurrogate endpointOncologyDose fractionationOdds ratioRandomized controlled trialQualitative researchClinical endpointSpecialtyHazard ratioProstateSurvival rateHead and neck cancerProstatectomyMEDLINEQuality of life (healthcare)Prostate cancerRadiosurgeryLarynxDysphagiaAdrenocortical carcinomaOropharyngeal squamous cell carcinomaToxicityAdjuvant radiotherapyConfidence intervalRadiation therapyFamily medicineBreast cancerClinical trialMedicinePandemicGastroenterologyMeta-analysis
33Publications
5H-index
137Citations
Publications 33
Newest
#1Laila A. Gharzai (UM: University of Michigan)H-Index: 5
#2N. Burger (UM: University of Michigan)H-Index: 1
Last. Michelle Mierzwa (UM: University of Michigan)H-Index: 15
view all 22 authors...
Introduction Optimal surveillance paradigms for survivors of early stage human papillomavirus (HPV)-related oropharyngeal cancer are not well defined. This study aimed to characterize patient interest in and factors associated with an altered surveillance paradigm. Materials and methods We surveyed patients with Stage I or II HPV-related oropharyngeal cancer treated at a tertiary care institution from 2016 to 2019. Primary outcomes were descriptive assessment of patient knowledge, interest in al...
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#1Laila A. Gharzai (UM: University of Michigan)H-Index: 5
#2Kerry A. Ryan (UM: University of Michigan)H-Index: 11
Last. Reshma Jagsi (UM: University of Michigan)H-Index: 76
view all 8 authors...
PURPOSE:Financial toxicity from cancer treatment is a growing concern. Its impact on patients requires refining our understanding of this phenomenon. We sought to characterize patients' experiences...
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#1Laila A. Gharzai (UM: University of Michigan)H-Index: 5
#2Kent A. Griffith (UM: University of Michigan)H-Index: 70
Last. Reshma Jagsi (UM: University of Michigan)H-Index: 76
view all 9 authors...
Background: Despite increasing representation of women in medicine, gender bias remains pervasive. The authors sought to evaluate speaker introductions by gender in the grand rounds of multiple specialties at a large academic institution to understand the cultural context of this behavior and identify predictors of formality. Materials and Methods: The authors reviewed grand rounds recordings of speakers with doctorates presenting to the departments of family medicine, general surgery, internal ...
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#1Michelle Mierzwa (UM: University of Michigan)H-Index: 15
#2Laila A. Gharzai (UM: University of Michigan)H-Index: 5
Last. Yue Cao (UM: University of Michigan)H-Index: 43
view all 17 authors...
ABSTRACT Purpose Prediction of individual patient sensitivity to radiotherapy (RT), for tumor control or normal tissue toxicity is necessary to individualize treatment planning. In head and neck cancer, radiation doses are limited by many nearby critical structures including structures involved in swallowing. Previous efforts showed that imaging parameters correlate with RT dose; here, we investigate the role of DCE-MRI blood volume (BV) changes in predicting dysphagia. Methods and Materials Thi...
1 CitationsSource
#1William C. Jackson (UM: University of Michigan)H-Index: 16
#2Holly E. Hartman (UM: University of Michigan)H-Index: 8
Last. Theodore S. Lawrence (UM: University of Michigan)H-Index: 104
view all 12 authors...
Abstract Purpose/Objective(s) Our individualized functional response adaptive approach to liver stereotactic body radiation therapy (SBRT) with assessment of indocyanine green (ICG) retention at baseline and mid-treatment to detect subclinical changes in liver function, permitting dose adjustment, has decreased toxicity while preserving efficacy. We hypothesized that assessment of the Albumin-Bilirubin (ALBI) score at baseline and mid-treatment would allow for more practical identification of pa...
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#1Laila A. Gharzai (UM: University of Michigan)H-Index: 5
#2Lauren A Szczygiel (UM: University of Michigan)
Last. Reshma Jagsi (UM: University of Michigan)H-Index: 76
view all 11 authors...
PURPOSE Accrual to clinical trials that challenge well-established treatment paradigms represents a unique challenge. Physician opinions on investigation of a novel approach to breast cancer treatment, in which patients with complete response to neoadjuvant chemotherapy are offered omission of lumpectomy, are unknown. NRG-CC006 sought to describe physician attitudes toward a novel approach to breast cancer treatment. METHODS We recruited 18 participants in the fields of surgery, medical oncology...
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#1Laila A. Gharzai (UM: University of Michigan)H-Index: 5
#2Ralph Jiang (UM: University of Michigan)H-Index: 1
Last. Daniel E. Spratt (UM: University of Michigan)H-Index: 50
view all 25 authors...
Summary Background The international Intermediate Clinical Endpoints in Cancer of the Prostate working group has established metastasis-free survival as a surrogate for overall survival in localised prostate cancer based on the findings of 19 predominantly radiotherapy-based trials. We sought to comprehensively assess aggregate trial-level performance of commonly reported intermediate clinical endpoints across all randomised trials in localised prostate cancer. Methods For this meta-analysis, we...
7 CitationsSource
#1Laila A. Gharzai (UM: University of Michigan)H-Index: 5
#2Pin Li (UM: University of Michigan)H-Index: 6
Last. Michelle Mierzwa (UM: University of Michigan)H-Index: 15
view all 15 authors...
Abstract Objectives Improved prognosis for p16+ oropharyngeal squamous cell carcinoma (OPSCC) has led to efforts to mitigate long-term complications of treatment, which remains poorly defined in late survivors. Here we characterize very late dysphagia in OPSCC. Materials and methods Long-term review of 93 p16+ OPSCC patients treated with chemoradiation was performed. We scored videofluoroscopic swallow studies (VFSS) according to the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) scale. V...
3 CitationsSource
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