Sridhar Muthusami
Karpagam University
Gene silencingPhosphorylationCancerInternal medicineEndocrinologyChromatin immunoprecipitationMolecular biologyProinflammatory cytokineBone remodelingTumor necrosis factor alphaChemistryApoptosisEstrous cycleRadiosensitivityCissus quadrangularisOxidative stressEpidermal growth factorInflammationHeLaSaos-2 cellsAntioxidantInflammatory bowel diseaseOsteoblastGlutathione peroxidaseUlcerative colitisLipid peroxidationCell cyclePolycystic ovaryEndocrine systemCancer researchColorectal cancerCancer stem cellRadioresistanceBioinformaticsSignal transductionBone resorptionHormoneMedicineOvariectomized ratBiologyImmune systemCell biology
25Publications
9H-index
481Citations
Publications 19
Newest
Background In individuals with ovarian cancer, an increase in the circulating level of the epidermal growth factor (EGF) is readily apparent. Ovarian cancer cells exhibit signaling pathway of the epidermal growth factor (EGFR) and respond to the EGF. Annona Muricata (AM) has been shown to decrease ovarian cell proliferation however, role of AM in regulating EGF actions is not yet to be reported. Objective In this study, we proposed that the fractionated compound acetogenin can inhibit the activa...
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#1Sridhar MuthusamiH-Index: 9
#2Ileng Kumaran Ramachandran (Farmingdale State College)H-Index: 1
Last. Ilangovan Ramachandran (UCLA: University of California, Los Angeles)
view all 8 authors...
Chronic inflammation can lead to the development of many diseases, including cancer. Inflammatory bowel disease (IBD) that includes both ulcerative colitis (UC) and Crohnmp's disease (CD) are risk factors for the development of colorectal cancer (CRC). Many cytokines produced primarily by the gut immune cells either during or in response to localized inflammation in the colon and rectum are known to stimulate the complex interactions between the different cell types in the gut environment result...
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#1Sridhar MuthusamiH-Index: 9
#2Ilangovan Ramachandran (University of Madras)H-Index: 11
Last. R. Ileng Kumaran (Farmingdale State College)H-Index: 1
view all 8 authors...
The development of colorectal cancer (CRC) is a multi-stage process. The inflammation of the colon as in inflammatory bowel disease (IBD) such as ulcerative colitis (UC) or Crohn's disease (CD) is often regarded as the initial trigger for the development of CRC. Many cytokines such as tumor necrosis factor alpha (TNF-α) and several interleukins (ILs) are known to exert proinflammatory actions, and inflammation initiates or promotes tumorigenesis of various cancers, including CRC through differen...
2 CitationsSource
#1Abhaya KrishnanH-Index: 2
#2Sridhar MuthusamiH-Index: 9
Last. Ilangovan Ramachandran (University of Madras)H-Index: 11
view all 6 authors...
Background and Objectives: Polycystic ovary syndrome (PCOS) is one of the most prevalent disorders among women of reproductive age. It is considered as a pro-inflammatory state with chronic low-grade inflammation, one of the key factors contributing to the pathogenesis of this disorder. Polycystic ovary is a well-established criterion for PCOS. The present investigation aimed at finding the role of hyperandrogenism, the most important feature of PCOS, in the development of this inflammatory stat...
4 CitationsSource
Hormones are known to influence various body systems that include skeletal, cardiac, digestive, excretory, and immune systems. Emerging investigations suggest the key role played by secretions of endocrine glands in immune cell differentiation, proliferation, activation, and memory attributes of the immune system. The link between steroid hormones such as glucocorticoids and inflammation is widely known. However, the role of peptide hormones and amino acid derivatives such as growth and thyroid ...
1 CitationsSource
#1Gautham Chengizkhan (University of Madras)
#2Bharti Bisht (UCLA: University of California, Los Angeles)H-Index: 6
Last. R. Ileng Kumaran (Farmingdale State College)H-Index: 1
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The discovery of cancer stem cells (CSCs) has revolutionized the field of cancer biology due to the intrinsic role of CSCs in the initiation, progression or relapse of cancers. The identification of different types of CSCs has given a great opportunity to researchers and clinicians, to understand the basic biology of various types of CSCs or cancers, and has also added an extra dimension in the development of innovative approaches or therapeutics to specifically target CSCs. The morbidity and mo...
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#1D. S. Prabakaran (CBNU: Chungbuk National University)H-Index: 4
#2Sridhar MuthusamiH-Index: 9
Last. Woo-Yoon Park (CBNU: Chungbuk National University)H-Index: 15
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Abstract Increasing evidence(s) suggests that cancer stem cells (CSC) in tumours contribute to radio-resistance and recurrence. Notch plays an important role in the maintenance of CSC in many cancers including cervical cancer. Previously, we have reported the role of Fused Toes Homolog (FTS) in conferring radioresistance in cervical cancer cells in vitro and human subjects. The present study investigated the regulatory role of FTS in Notch signaling and maintenance of CSC upon irradiation of cer...
7 CitationsSource
Abstract According to the World Health Organization (WHO) polycystic ovary syndrome (PCOS) occurs in 4-8% of women worldwide. The prevalence of PCOS in Indian adolescents is 12.2% according to the Indian Council of Medical Research (ICMR). The National Institute of Health has documented that it affects approximately 5 million women of reproductive age in the United States. Hormonal imbalance is the characteristic of many women with polycystic ovarian syndrome (PCOS). The influence of various end...
40 CitationsSource
#1Sridhar Muthusami (University of Madras)H-Index: 9
#2V. Gopalakrishnan (University of Madras)H-Index: 4
Last. Narasimhan Srinivasan (University of Madras)H-Index: 26
view all 7 authors...
Abstract The increasing evidence suggesting the role of free radicals in bone resorption and bone loss prompted us to explore whether the consumption of antioxidant rich medicinal plant C. quadrangularis modifies antioxidant status in ovariectomized rats. Methods Twenty four female adult rats, 90 days old showing regular estrous cycles were used for the present study. The animals were divided into two groups. The Group-1 rats (n = 6) were sham operated and Group-II rats were bilaterally ovariect...
2 CitationsSource
#1Da Bin Seong (CBNU: Chungbuk National University)H-Index: 1
#2Semie Hong (Konkuk University)H-Index: 2
Last. Woo-Yoon Park (CBNU: Chungbuk National University)H-Index: 15
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Cordycepin (3-deoxyadenosine) has many pharmacological activities. We studied the radiosensitising effect of cordycepin and the underlying mechanisms relating to cell cycle changes in two human uterine cervical cancer cell lines, ME180 and HeLa cells. Cordycepin produced concentration- and time-dependent reductions in cell viability with more pronounced effects in ME180 cells. Cells pre-treated with cordycepin showed lower cell survival than those exposed to irradiation only. Radiation-induced e...
18 CitationsSource