Ashok Handa
University of Oxford
Internal medicineRadiologyEndocrinologySurgeryMagnetic resonance imagingPsychologyCardiologyIntensive care medicineProspective cohort studyEmergency medicineAortic aneurysmAsymptomaticMEDLINEAbdominal aortic aneurysmCarotid endarterectomyTransplantationComputer scienceIncidence (epidemiology)Medical emergencyGeneral surgeryMedicineBiomarker (medicine)Biology
276Publications
21H-index
2,321Citations
Publications 199
Newest
#1E Ngetich (John Radcliffe Hospital)
#2Pierfrancesco Lapolla (John Radcliffe Hospital)
Last. R Lee
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Abdominal aortic aneurysm (AAA) is an important vascular disease carrying significant mortality implications due to the risk of aneurysm rupture. Current management relies exclusively on surgical repair as there is no effective medical therapy. A key element of AAA pathogenesis is the chronic inflammation mediated by inflammatory cells releasing proteases, including the enzyme dipeptidyl peptidase IV (DPP-IV). This review sought to recapitulate available evidence on the involvement of DPP-IV in ...
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#1P. Loick (University of Oxford)
#2Goran Mohammad (University of Oxford)H-Index: 6
Last. Samira Lakhal-Littleton (University of Oxford)H-Index: 9
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Rationale: Hepcidin (HAMP) is a hormone produced primarily in the liver. It controls systemic iron homeostasis by inhibiting the iron exporter ferroportin (FPN) in the gut and spleen, respective sites of iron absorption and recycling. HAMP and FPN are also found ectopically in tissues not involved in systemic iron homeostasis. The physiological functions of ectopic HAMP and FPN are only just beginning to be uncovered. We observed that HAMP expression is markedly increased in smooth muscle cells ...
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#1Sonali Munshaw (University of Oxford)H-Index: 1
#2Susann Bruche (University of Oxford)H-Index: 5
Last. Nicola Smart (University of Oxford)H-Index: 28
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Vascular stability and tone are maintained by contractile smooth muscle cells (VSMCs). However, injury-induced growth factors stimulate a contractile-synthetic phenotypic modulation which increases susceptibility to abdominal aortic aneurysm (AAA). As a regulator of embryonic VSMC differentiation, we hypothesised that Thymosin β4 (Tβ4) may function to maintain healthy vasculature throughout postnatal life. This was supported by the identification of an interaction with Low density lipoprotein re...
2 CitationsSource
#1Christina Kassiteridi (University of Oxford)H-Index: 5
#2Jennifer Cole (University of Oxford)H-Index: 13
Last. Claudia Monaco (University of Oxford)H-Index: 49
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Rationale: Inflammation is a basic component of the pathogenesis of atherosclerosis. CD200 is an immune checkpoint known to control macrophage activation. CD200 recently emerged in the Framingham Heart Study and 2 other cohorts as being potentially relevant in CVD. The role of this pathway in CVD is unknown. Objective: We sought to examine the role of CD200 in atherosclerosis. Methods and Results: Using hypercholesterolemic ApoE-/- mice, we demonstrate that whole-body CD200 deficiency augments a...
1 CitationsSource
#1Soham Bandyopadhyay (University of Oxford)H-Index: 6
#2Ioannis Georgiou (University of Oxford)H-Index: 1
Last. Kate E. A. Saunders (University of Oxford)H-Index: 26
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4 CitationsSource
#2Ashok HandaH-Index: 21
Last. Regent LeeH-Index: 19
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Background Intravenous contrast agents are routinely used in computerized tomography (CT) imaging to enable the visualisation of intravascular pathology, such as with abdominal aortic aneurysms (AAA). However, the injection is contraindicated in patients with iodine allergy and is associated with renal complications. Objectives In this study, we investigate if the raw data acquired from a non-contrast CT image contains sufficient information to differentiate blood and other soft tissue component...
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#2Ashok HandaH-Index: 21
Last. Regent LeeH-Index: 19
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OBJECTIVE We investigated the utility of geometric features for future abdominal aortic aneurysms (AAA) growth prediction. BACKGROUND Novel methods for growth prediction of AAA are recognised as a research priority. Geometric feature has been applied to predict cerebral aneurysm rupture, but not examined as predictor of AAA growth. METHODS Computerised tomography (CT) scans from patients with infra-renal AAAs were analysed. Aortic volumes were segmented using an automated pipeline to extract AAA...
2 CitationsSource
#1Anirudh Chandrashekar (University of Oxford)H-Index: 2
#2Ashok Handa (University of Oxford)H-Index: 21
Last. Regent Lee (University of Oxford)H-Index: 19
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Background Existing methods to reconstruct vascular structures from a computerized tomography (CT) angiogram rely on contrast injection to enhance the radio-density within the vessel lumen. However, pathological changes in the vasculature may be present that prevent accurate reconstruction. In aortic aneurysmal disease, a thrombus adherent to the aortic wall within the expanding aneurysmal sac is present in > 90% of cases. These deformations prevent the automatic extraction of vital clinical inf...
2 CitationsSource
#1Joel Ward (John Radcliffe Hospital)H-Index: 1
#1Joel Ward (John Radcliffe Hospital)H-Index: 1
Last. Regent LeeH-Index: 19
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Abdominal aortic aneurysms (AAA) are associated with systemic inflammation and endothelial dysfunction. We previously reported flow mediated dilatation (FMD) of the brachial artery as a predictor of AAA growth. We hence hypothesised that other physical characteristics of the brachial artery correlate with AAA growth. Using a prospectively cohort of AAA patients, we devised a "brachial artery relaxation index" (BARI) and examined its role as a biomarker for AAA growth. However, no correlation bet...
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#1Anirudh Chandrashekar (University of Oxford)H-Index: 2
#2Ashok Handa (University of Oxford)H-Index: 21
Last. Regent Lee (University of Oxford)H-Index: 19
view all 6 authors...
Existing methods to reconstruct vascular structures from a computed tomography (CT) angiogram rely on injection of intravenous contrast to enhance the radio-density within the vessel lumen. However, pathological changes can be present in the blood lumen, vessel wall or a combination of both that prevent accurate reconstruction. In the example of aortic aneurysmal disease, a blood clot or thrombus adherent to the aortic wall within the expanding aneurysmal sac is present in 70-80% of cases. These...
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