Huate Li
Boston University
Isometric exerciseOpticsPhysicsAfterloadAdaptive opticsBiomedical engineeringDeformable mirrorMicroscopyRaman scatteringDepth of fieldChemistryWork (physics)Focus (optics)Materials scienceLens (optics)In vivoPresentation (obstetrics)Shack–Hartmann wavefront sensorOptical coherence tomographyCardiac muscleDynamic controlStimulated ramanDepth of focusContractilityHorizontal scan ratePreloadTissue engineeringChemical imagingMicroscope
4Publications
1H-index
2Citations
Publications 5
Newest
#2Christopher S. ChenH-Index: 107
view all 7 authors...
Three-dimensional engineered heart tissues (EHTs) derived from human induced pluripotent stem cells (iPSCs) have become an important resource for both drug toxicity screening and research on heart disease. A key metric of EHT phenotype is the contractile force with which the tissue spontaneously beats. It is well-known that cardiac muscle contractility – its ability to do mechanical work – depends on tissue prestrain (preload) and external resistance (afterload). Objectives: Here, we demonstrate...
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#1Peng Lin (BU: Boston University)H-Index: 6
#2Hongli Ni (BU: Boston University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 7 authors...
Stimulated Raman scattering (SRS) microscopy enables the imaging of molecular events on a human subject in vivo, such as filtration of topical drugs through the skin and intraoperative cancer detection. A typical approach for volumetric SRS imaging is through piezo scanning of an objective lens, which often disturbs the sample and offers a low axial scan rate. To address these challenges, we have developed a deformable mirror-based remote-focusing SRS microscope, which not only enables high-qual...
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#1Peng Lin (BU: Boston University)H-Index: 6
#2Hongli Ni (BU: Boston University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 8 authors...
Operable under ambient light and providing chemical selectivity, stimulated Raman scattering (SRS) microscopy opens a new window for imaging molecular events on a human subject, such as filtration of topical drugs through the skin. A typical approach for volumetric SRS imaging is through piezo scanning of an objective lens, which often disturbs the sample and offers a low axial scan rate. To address these challenges, we have developed a deformable mirror-based remote-focusing SRS microscope, whi...
2 CitationsSource
#1Thomas G. Bifano (BU: Boston University)H-Index: 32
#2Huate LiH-Index: 1
An adaptive scanning optical microscope with extended depth of field (ASOM-EDOF) is described. The system is based on the ASOM developed previously*, and uses a custom-built Thorlabs 0.21NA objective with a 75mm pupil diameter that allows scanned imaging over a circular region of 40mm diameter using fast steering mirror. The microscope is configured for fluorescence imaging with epi-illumination. A 140 actuator, 5.5µm stroke DM is conjugated to the pupil of the objective, and is used in conjunct...
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#1Peng LinH-Index: 6
#2Hongli NiH-Index: 1
Last. Ji-Xin ChengH-Index: 83
view all 8 authors...
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