Wenhua Jing
Shenyang Pharmaceutical University
Proton NMRCytotoxicityDocking (molecular)Circular dichroismCytotoxic T cellGenusCarbon-13 NMRChemistryApoptosisPhytochemicalTwo-dimensional nuclear magnetic resonance spectroscopyG1 phaseIn silicoPhenylpropanoidCaesalpiniaLactoneInflammationLeptopusHeLaCaesalpinia bonducEuphorbiaceaeMedicinal plantsNatural productAnti-inflammatoryTarget proteinTricyclicVEGF Signaling PathwayMolecular Docking SimulationBiological propertyBroad spectrumProtein structureBiosynthesisBiochemistryTraditional medicinePharmacophoreMAPK/ERK pathwaySignal transductionPhosphodiesteraseComputational biologyStereochemistryProtein kinase B
5Publications
3H-index
24Citations
Publications 5
Newest
#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 9 authors...
Abstract Our present and previous phytochemical investigations on Leptopus lolonum have resulted in the isolation of almost 30 phenylpropanoid-conjugated pentacyclic triterpenoids (PCPTs). During the continuous study on PCPTs, this kind of triterpenoid ester is considered as a natural product with low toxicity because of it’s widely distribution in natural plants and edible fruits including kiwi fruit, durian, jujube, pawpaw, apple and pear. In the present work, we report the isolation, structur...
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#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 10 authors...
Abstract Most of Euphorbiaceae plants are considered as folk medicinal plants because of their various pharmacological effects. However, there are eight Leptopus genus plants which belong to Euphorbiaceae have never be investigated. Thus, four Leptopus genus plants were collected to study their chemical constituents and pharmacological activities. In the present work, the cytotoxicities of the extracts of four Leptopus genus plants were evaluated before phytochemical experiments. And nine new ph...
1 CitationsSource
#1Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract In this paper, chemical investigation on the chloroform soluble fraction of seed kernels of Caesalpinia bonduc resulted in the isolation of five new cassane diterpenoids: norcaesalpinin O (1), norcaesalpinin P (2), caesalpinin MQ (3), caesall O/P (4/5) and seven known compounds (6-12). Compounds structures were elucidated by 1H NMR, 13C NMR, 2D NMR, HR-MS and ECD (electronic circular dichroism) spectral analysis. The characters for new compounds with the presence of an aromatized C ring...
2 CitationsSource
#1Wenhua Jing (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 7 authors...
Abstract Natural products, especially diterpenoids, are enriched with numerous compounds with a broad spectrum of therapeutic indications, suggesting that functional moieties serve as a core pharmacophore. Cassane diterpenoids (CAs), as the main and characteristic constituents of medical plants in the Caesalpinia genus, have been widely studied due to their bioactivities, and >450 compounds have been reported since the 1960s, including 283 compounds that have been reported in the past decade. Th...
13 CitationsSource
#1Ying Wang (SPU: Shenyang Pharmaceutical University)H-Index: 13
#1Ying Wang (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 2
view all 7 authors...
Cassane diterpenoids (CAs), recognized as main constituents of many medical plants of the genus Caesalpinia, exhibit diverse bioactivities, including anti-inflammatory and immunomodulatory activity, and also showed a therapeutic effect on rheumatoid arthritis (RA) according to previous work, including ours. In this study, 102 CA compounds were selected to explore the possible molecular mechanism of this class of natural products on anti-inflammatory and immunomodulatory activity using RA as a di...
6 CitationsSource