Xiaomeng Ding
Nanchang University
ChemokineKEGGReceptorTight junctionTumor necrosis factor alphaBiochemical engineeringChemistryApoptosisCaco-2AutophagyStimulationCytokine receptorColitisOxidative stressKEAP1InflammationCD80CytokineLipopolysaccharideMacrophageMyeloidAcroleinUlcerative colitisFlexibility (engineering)ATG5Intestinal epitheliumCD86Intestinal cellIntestinal MetabolismCytochrome cIntestinal absorptionIntestinal immunityFuture studyIntestinal transportComputer scienceSecretionViability assayMAPK/ERK pathwaySignal transductionProtein kinase BPI3K/AKT/mTOR pathwayImmune systemCell biology
7Publications
3H-index
28Citations
Publications 7
Newest
#1Yudan Wang (NCU: Nanchang University)H-Index: 2
#2Xiaomeng Ding (NCU: Nanchang University)H-Index: 3
Last. Qiang Yu (NCU: Nanchang University)H-Index: 21
view all 9 authors...
Abstract The previous research has indicated that Ganoderma atrum polysaccharide (PSG-1) indirectly affects the immune function of dendritic cells (DCs) in intestinal-like Caco-2/DCs co-culture model, in which NF-κB and MAPK pathway play an essential role. To explore the interaction of Caco-2 in the interaction between the intestinal epithelium and its internal immune cells, the intestinal-like Caco-2/DCs co-culture model was developed. All transcripts of Caco-2 treated with or without PSG-1 wer...
1 CitationsSource
#1Xiaomeng Ding (NCU: Nanchang University)H-Index: 3
#2Xiaoyi Hu (NCU: Nanchang University)H-Index: 3
Last. Qiang Yu (NCU: Nanchang University)H-Index: 21
view all 7 authors...
Abstract Background Food-intestine interaction study has always been a hot topic in food science and nutrition due to diverse physiological functions of intestine. Compared to expensive animal models with limited screening capabilities, the simple, reliable and highly reproducible intestinal cell models are widely used in food-intestine interaction study. There are many functional cell models used to simulate the intestine in vitro, among which the Caco-2 cell model is one of the most widely use...
5 CitationsSource
#1Bing ZhengH-Index: 3
#2Mengxi YingH-Index: 3
Last. Qiang YuH-Index: 21
view all 9 authors...
Polysaccharides are one of the main active substances in Ganoderma atrum (G. atrum). The purpose of this study was to explore the protective effect of a G. atrum polysaccharide (PSG-1) on DSS-induced colitis and the underlying mechanism. The results showed that PSG-1 could maintain the integrity of the intestinal structure by promoting the expression of goblet cells and levels of tight junction proteins in the colon of DSS-induced colitis mice. Furthermore, PSG-1 relieved the inhibition of Bcl-2...
2 CitationsSource
#1Xiaoyi Hu (NCU: Nanchang University)H-Index: 3
#2Qiang Yu (NCU: Nanchang University)H-Index: 21
Last. Mingyong Xie (NCU: Nanchang University)H-Index: 71
view all 8 authors...
Abstract Lipopolysaccharide (LPS)-induced inflammatory macrophages model and intestinal-like Caco-2/macrophages co-culture inflammation model were established to evaluate the anti-inflammatory effect and underlying mechanism of Ganoderma atrum polysaccharides (PSG-1). It was found that PSG-1 reduced LPS-induced secretion of pro-inflammatory cytokine (TNF-α, IL-6 and IL-1β), ROS levels, and inhibited the expression of COX-2 in LPS-stimulated inflammatory macrophages model and intestinal-like Caco...
7 CitationsSource
#1Xiaomeng Ding (NCU: Nanchang University)H-Index: 3
#2Qiang Yu (NCU: Nanchang University)H-Index: 21
Last. Mingyong Xie (Jiangxi Normal University)H-Index: 71
view all 9 authors...
Abstract Our previous study has demonstrated that Ganoderma atrum polysaccharide (PSG-1) activated the immune response of dendritic cells (DCs) by direct contacting with surface receptors. However, as a kind of macromolecule compound, PSG-1 cannot directly stimulate DCs via passing through the intestine epithelial cells. To investigate the role of PSG-1 in the interaction between the intestinal epithelium and its internal immune cells, the intestinal-like Caco-2/DCs co-culture model was establis...
4 CitationsSource
#1Kunyou Hou (NCU: Nanchang University)H-Index: 5
#2Qiang Yu (NCU: Nanchang University)H-Index: 21
Last. Mingyong Xie (NCU: Nanchang University)H-Index: 71
view all 9 authors...
Abstract The study aimed to investigate the protective effect and underlying mechanism of Ganoderma atrum (G. atrum) polysaccharide (PSG-1) on macrophage injury induced by acrolein. The results showed that PSG-1 restored the cell viability damaged by acrolein. In addition, PSG-1 significantly reduced the acrolein-induced occurrence of apoptosis via increase of Bcl-2 expression, mitochondrial membrane potential (MMP), decrease of ROS, cytochrome c (Cyt-C), caspase-3, caspase-9. Moreover, the over...
9 CitationsSource
#1Hui Wang (NCU: Nanchang University)H-Index: 10
#1Hui Wang (NCU: Nanchang University)H-Index: 11
Last. Mingyong Xie (NCU: Nanchang University)H-Index: 71
view all 8 authors...
Abstract Our previous study has demonstrated that Ganoderma atrum polysaccharide (PSG-1) could induce activation and maturation of dendritic cells (DCs). Hereby, this study aimed to further elucidate the underlying mechanism of PSG-1 induced immune activation based on RNA-seq. The results of RNA-seq analysis showed 2231 differentially expressed genes between PSG-1 and control group. 28 biological processes terms, 20 molecular functions terms, and 10 cellular components terms were identified by G...
9 CitationsSource