Yamei Liu
Guangzhou University
PromoterRegenerative medicineInternal medicineCpG sitemicroRNACellCalcitriol receptorChemistryTraditional Chinese medicineDNA methylationMesenchymal stem cellIn vitroIn vivoRUNX2Western blotOsteoporosisAntioxidantOsteoblastBone marrowWNT5ADPPHStem cellBone regenerationMethylationEpigeneticsCancer researchViability assayTransfectionMedicineBone healingBiologyHedgehog signaling pathwayCell biologyPharmacology
19Publications
9H-index
200Citations
Publications 19
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#1Yonghui Hou (Guangzhou University of Chinese Medicine)H-Index: 6
#2Weiping Lin (CUHK: The Chinese University of Hong Kong)H-Index: 8
Last. Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
view all 9 authors...
Abstract Background Mesenchymal stem cells (MSCs) are promising targets for therapeutic use in regenerative medicine and tissue engineering. In the previous study, we have found that MSCs could be reverted to a primitive stem cell population after in vitro induction of osteogenic and de-osteogenic differentiation (de-osteogenic differentiated MSCs, De-Os-MSCs). De-Os-MSCs showed improved cell survival and osteogenic potential. However, the underlying mechanism and its potential effect on fractur...
1 CitationsSource
#1Jun-Lang Zhu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Wang Bin (Guangzhou University of Chinese Medicine)H-Index: 4
view all 14 authors...
Abstract Background Mesenchymal Stem Cells (MSCs) therapy has become a new coming focus of clinical research in regenerative medicine. However, only a small number of implanted MSCs could successfully reach the injured areas. The previous studies have shown that fracture healing time is inversely proportional to concentration of MSCs in injured tissue. Methods The migration and osteogenesis of MSCs were assessed by transwell assay and Alizarin Red S staining. Levels of gene and protein expressio...
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#1Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
Last. Gang Li (CUHK: The Chinese University of Hong Kong)H-Index: 84
view all 12 authors...
Abstract Mesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. MSCs could be recruited by inflammatory stimulation, then home to the injury tissues. However, its capacity of homing is extremely limited. Thus, it has become extremely necessary to develop an agent or a method, which can be us...
1 CitationsSource
#1Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Wang-Yang Li (Hunan University)H-Index: 1
Last. Wang Bin (GU: Guangzhou University)H-Index: 4
view all 14 authors...
ABSTRACT MSC transplantation has been explored as a new clinical approach to stem cell-based therapies for bone diseases in regenerative medicine due to their osteogenic capability. However, only a small population of implanted MSC could successfully reach the injured areas. Therefore, enhancing MSC migration could be a beneficial strategy to improve the therapeutic potential of cell transplantation. Catharmus tinctorius volatile oil (CTVO) was found to facilitate MSC migration. Further explorat...
2 CitationsSource
#1Bin Fang (Guangzhou University of Chinese Medicine)H-Index: 6
#2Ying Li (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
view all 11 authors...
Abstract Ethnopharmacological relevance Traditional Chinese medicine has a long history of treating various bone diseases including osteoporosis and osteonecrosis etc. In clinical treatment, Huo Xue Tong Luo capsule (HXTL capsule) containing Peach kernel, Safflower carthamus, Angelica sinensis, Ligusticum wallichii etc, is one of the mostly used prescriptions for treating osteonecrosis of the femoral head (ONFH) with promising effects. Objectives This study aims to identify the underlying molecu...
9 CitationsSource
#1Liuchao Hu (Guangzhou University of Chinese Medicine)H-Index: 1
#1Liuchao Hu (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Yiwen Luo (Guangzhou University of Chinese Medicine)H-Index: 5
view all 13 authors...
: Bone fractures are very common, and above 5% of the fractures are impaired, leading to nonunions and severe disablilities. The traditional Chinese medicine Bushen Huoxue decoction (BHD) has been used to treat fracture in China. Our previous report has found that BHD promotes migration of rat mesenchymal stem cells (rMSCs) by activating Wnt5a signaling pathway. However, whether and how miRNAs are involved in modulating rMSCs migration induced by BHD has not been explored. In the present study, ...
2 CitationsSource
#1Yanming Cao (Guangzhou Medical University)H-Index: 3
#2Bin WangH-Index: 13
Last. Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
view all 11 authors...
Purpose. SOST gene is one of the key factors in regulating bone absorption. Although there are reports showing diverse transcription factors, epigenetic modification could be responsible for regulating SOST gene expression. There is still little exploration on promoter methylation status of SOST gene in osteoporotic bone tissues. The aim of this study is to investigate the involvement of CpG methylation in regulation of SOST expression in patients with primary osteoporosis. Methods. The diagnosi...
5 CitationsSource
#1Bin Fang (GU: Guangzhou University)H-Index: 6
#2Ding Wang (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Liangliang Xu (GU: Guangzhou University)H-Index: 22
view all 11 authors...
Background The etiology and pathology osteonecrosis of the femoral head (ONFH) are not completely clarified. As a cytokine participating in systemic inflammation, tumor necrosis factor alpha (TNFα) has been shown to be involved in the pathogenesis of ONFH. However, the role of TNFα in ONFH is not clearly clarified. In the present study, we investigated the effects of TNFα on proliferation, angiogenesis, and osteogenic differentiation of rat bone mesenchymal stem cells (rMSCs) and the underlying ...
7 CitationsSource
#1Qiuke Hou (Guangzhou University of Chinese Medicine)H-Index: 7
#2Yongquan Huang (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 9 authors...
Our previous study showed that (+)-cholesten-3-one (CN) has the potential to induce the osteoblastic differentiation of mesenchymal stem cells (MSCs). However, the roles of CN in targeting miRNA-mRNA-lncRNA interactions to regulate osteoblast differentiation remain poorly understood. A total of 77 miRNAs (36 upregulated and 41 downregulated) and 295 lncRNAs (281 upregulated and 14 downregulated) were significantly differentially expressed during CN-induced MSC osteogenic differentiation. Bioinfo...
9 CitationsSource