Xinxin Zhang
Shenyang Pharmaceutical University
TriterpenoidCytotoxicityCytotoxic T cellGenusProinflammatory cytokineEnzymeChemistryApoptosisGlycosidePhytochemicalTwo-dimensional nuclear magnetic resonance spectroscopyIn vitroMyeloperoxidaseIn vivoG1 phaseColitisActinidia argutaOxidative stressPhenylpropanoidCaesalpiniaLactoneInflammationLeptopusHeLaLipopolysaccharideEuphorbiaceaeMedicinal plantsOleananeNatural productAglyconeAnti-inflammatoryHemolysistert-Butyl hydroperoxideTricyclicHydrolysateXanthocerasideLeptopus chinensisDoxorubicin HydrochlorideBiological propertyInhibitory effectStructural typeDried fruitPentacyclic triterpenoidsNo productionAnti tumourBroad spectrumCarbohydrate chainsReactive oxygen speciesPhytochemistryViability assayBiosynthesisBiochemistryTraditional medicinePharmacophoreMAPK/ERK pathwayStereochemistryProtein kinase BPharmacology
8Publications
3H-index
41Citations
Publications 8
Newest
#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract null null The first investigation of phytochemistry on the seed kernels of Caesalpinia sinensis led to the isolation and characterization of six new compounds including three tricyclic-type cassane diterpenoids (1‐–3) and three norcassane-type diterpenoids (4–6), together with three know compounds (7–9). Compounds 1–9 represented the first discovery of cassane-type diterpenoids from C. sinensis. Their structures were elucidated by a combination of spectroscopic analysis, single-crystal ...
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#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Our present and previous phytochemical investigations on Leptopus lolonum have resulted in the isolation of almost 30 phenylpropanoid-conjugated pentacyclic triterpenoids (PCPTs). During the continuous study on PCPTs, this kind of triterpenoid ester is considered as a natural product with low toxicity because of it’s widely distribution in natural plants and edible fruits including kiwi fruit, durian, jujube, pawpaw, apple and pear. In the present work, we report the isolation, structur...
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#1Liping LongH-Index: 3
Last. Huiyuan GaoH-Index: 12
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#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Most of Euphorbiaceae plants are considered as folk medicinal plants because of their various pharmacological effects. However, there are eight Leptopus genus plants which belong to Euphorbiaceae have never be investigated. Thus, four Leptopus genus plants were collected to study their chemical constituents and pharmacological activities. In the present work, the cytotoxicities of the extracts of four Leptopus genus plants were evaluated before phytochemical experiments. And nine new ph...
1 CitationsSource
#1Yiren Yang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Liping Long (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Luping Sha (SPU: Shenyang Pharmaceutical University)H-Index: 2
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Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides. In order to find more BATs as new anti-tumor agents with much more efficiency, the chemical and pharmaceutical studies were carried out on the acid hydrolysate product (AHP) of Semen Aesculi crude extract. Thirteen BATs, including three new aglycones (1–3), two new glycosides (4, 5) a...
1 CitationsSource
#1Lian LianH-Index: 1
#2Song Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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In this study, we aimed at investigating the antiinflammatory activity of the freeze-dried fruit powder of Actinidia arguta (FAA) on dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice and the effect of its extract on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. For pharmacodynamic studies, the oral administration of FAA (300 or 600 mg kg−1) could decrease the disease activity index (DAI), reduce the incidence of colon and spleen edemas (caused by inflammation), a...
5 CitationsSource
#1Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Song Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Barrigenol-like triterpenoids (BATs), which contain an unusual oleanane substituted by many hydroxyl groups as the skeleton, are subdivided into five subtypes: barrigenol A 1 , barrigenol A 2 , barrigenol R 1 , barringtogenol C, and 16-deoxybarringtogenol C. The variations in acyl derivatives, hydroxyl groups, and carbohydrate chains in their structures have enhanced the diversity of BATs. Moreover, the stable polyhydroxy-replaced pentacyclic skeleton provides an ideal platform for stru...
19 CitationsSource
#1Wenhua Jing (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Natural products, especially diterpenoids, are enriched with numerous compounds with a broad spectrum of therapeutic indications, suggesting that functional moieties serve as a core pharmacophore. Cassane diterpenoids (CAs), as the main and characteristic constituents of medical plants in the Caesalpinia genus, have been widely studied due to their bioactivities, and >450 compounds have been reported since the 1960s, including 283 compounds that have been reported in the past decade. Th...
18 CitationsSource