Zihao Xu
Iowa State University
ParticleSelf-healing hydrogelsRadical polymerizationSurface modificationSubstrate (chemistry)BiophysicsMethacrylateAtom-transfer radical-polymerizationJanus particlesPhotopolymerNanoparticleChain-growth polymerizationNitroxide mediated radical polymerizationNanotechnologyChemistryPolymer chemistryMaterials scienceEmulsion polymerizationDumbbellDispersion polymerizationEne reactionPolystyreneBiomaterialSwellingMaterial selectionGellan gumThiolCytokine secretionIn situ fabricationHost responseReversible addition-fragmentation chain-transfer polymerizationChemical engineeringPolymerizationTissue engineeringPolymerContact angleCobalt-mediated radical polymerizationClick chemistryPhotochemistryAdhesionIonic polymerizationCell adhesionProtein adsorptionLiving free-radical polymerization
7Publications
4H-index
66Citations
Publications 7
Newest
#1Zihao Xu (Iowa State University)H-Index: 4
#2Dohgyu Hwang (Iowa State University)H-Index: 5
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
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Abstract Adhesion of macrophages to material substrates plays an essential role in many biological behaviors and biomedical procedures, including wound healing, cancer treatment and biomaterial implantation. Therefore, altering the adhesion of macrophages using biomaterial design may help control their biological function. In this work, we developed a straightforward method to render the hydrogel surface more hydrophobic and demonstrated that the adhesion of macrophages on hydrogels was enhanced...
2 CitationsSource
#1Zihao Xu (Iowa State University)H-Index: 4
#2Dohgyu Hwang (Iowa State University)H-Index: 5
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
view all 5 authors...
A balance of macrophage phenotypes is essential in successful implantation. Therefore, biomaterials should be carefully designed to better regulate the response of macrophages. We demonstrate macrophage adhesion and phenotypic shifts can be modulated with hydrophobically modified hydrogels. This study represents a fundamental concept in controlling cell adhesion and differentiation with substrate hydrophobicity. Gel synthesis was carried out using methacrylated gellan gum (MGG), which was polyme...
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#1Yifan Li (Iowa State University)H-Index: 5
#2Shensheng Chen (Binghamton University)H-Index: 3
Last. Shan Jiang (Iowa State University)H-Index: 26
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Abstract Emulsion polymerization is a versatile approach to produce different polymeric nanoparticle morphologies, which can be useful in a variety of applications. However, the detailed mechanism of the morphology formation is not entirely clear. We study the kinetics of nanoparticle morphology evolution during a seeded emulsion polymerization using both experimental and computational tools. Lightly crosslinked polystyrene seeds were first synthesized using dispersion polymerization. Then the s...
17 CitationsSource
#1Zihao Xu (Iowa State University)H-Index: 4
#2Zhuqing Li (Iowa State University)H-Index: 2
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
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Gellan gum is a naturally occurring polymer that can cross-link in the presence of divalent cations to form biocompatible hydrogels. However, physically cross-linked gellan gum hydrogels lose their stability under physiological conditions, thus restricting the applications of these hydrogels in vivo. To improve the mechanical strength of the gels, we incorporated methacrylate into the gellan gum and chemically cross-linked the hydrogel through three polymerization methods: step growth through th...
15 CitationsSource
#1Zihao Xu (Iowa State University)H-Index: 4
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
This Review gives a brief introduction to hydrogels formed through click chemistry for applications in tissue engineering. Specifically, we focus on three representative click chemistry mechanisms: Diels–Alder reactions, azide–alkyne cycloaddition, and thiol–ene chemistry. Apart from that, we also discuss photoinitiated chain growth polymerization, which also has fast kinetics. The chemical mechanisms of these reactions, along with their advantages and disadvantages, are presented. These gelatio...
15 CitationsSource
Source
#1Jianping SunH-Index: 2
#2Yang ZhangH-Index: 2
Last. Zihao XuH-Index: 4
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Low concentration limitations of the catalyst and conventional free radical polymerization are investigated in the system of initiators for continuous activator regeneration atom transfer radical polymerization (ICAR ATRP) of butyl methacrylate (BMA), in which 2,2-azobisisobutyronitrile (AIBN) is used as a reducing agent, pentamethyldiethylenetriamine (PMDETA) as a ligand, copper bromide (CuBr2) as a catalyst and ethyl 2-bromoisobutyrate (EBiB) as an initiator. Results show that conventional rad...
4 CitationsSource