Jong-Soo Lee
Chungnam National University
FermentationViral replicationSurgeryVirologyEnzymeChemistryIn vitroIn vivoVirusIsolation (microbiology)InterferonInfluenza A virusSaccharomyces cerevisiaeYeastFood scienceBiochemistryBotanyMedicineBiologyImmune systemMicrobiologyCell biology
Publications 256
#2Eun-Jin Kim (Korea Research Institute of Bioscience and Biotechnology)H-Index: 2
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has posed a devastating threat worldwide. The receptor-binding domain (RBD) of the spike protein is one of the most important antigens for SARS-CoV-2 vaccines, while the analysis of CD8 cytotoxic T lymphocyte activity in preclinical studies using mouse models is critical for evaluating vaccine efficacy. Here, we immunized C57BL/6 wild-type mice and transgenic mice expressing human angiotensin-converting enzyme 2 (ACE2) with the SARS-CoV-2 RBD pr...
#1Su Yeon Lee (CNU: Chungnam National University)
#2Jee Na Lee (CNU: Chungnam National University)H-Index: 1
Last. Won Ho Park (CNU: Chungnam National University)H-Index: 61
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Abstract Hypothesis: Functional adhesives with excellent adhesive strength in wet as well as dry environments are actively studied for various applications. In particular, the adhesion mechanism of marine organisms has been imitated to achieve strong adhesion in wet environments. Experiments: Polyallylamine (PAA) was modified with catechol groups (CA), which mimic the mussel adhesion proteins, and gallol groups (GA) found in tunicates to compare the gelation, self-healing, and adhesive propertie...
Last. Jong-Soo LeeH-Index: 31
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Sargassum fusiforme, a plant used as a medicine and food, is regarded as a marine vegetable and health supplement to improve life expectancy. Here, we demonstrate that S. fusiforme extract (SFE) has antiviral effects against respiratory syncytial virus (RSV) in vitro and in vivo mouse model. Treatment of HEp2 cells with a non-cytotoxic concentration of SFE significantly reduced RSV replication, RSV-induced cell death, RSV gene transcription, RSV protein synthesis, and syncytium formation. Moreov...
#1Pathum Ekanayaka (CNU: Chungnam National University)H-Index: 2
#2Seo-Yong Lee (CNU: Chungnam National University)H-Index: 9
Last. Jong-Soo Lee (CNU: Chungnam National University)H-Index: 31
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VP1, a pivotal capsid protein encoded by the foot-and-mouth disease virus (FMDV), plays an important role in receptor-mediated attachment and humoral immune responses. Previous studies show that amino acid changes in the VP1 protein of cell culture-adapted strains of FMDV alter the properties of the virus. In addition, FMDV VP1 modulates host IFN signal transduction. Here, we examined the ability of cell culture-adapted FMDV VP1(83K) and wild-type FMDV VP1(83E) to evade host immunity by blocking...
2 CitationsSource
#1Kiramage Chathuranga (CNU: Chungnam National University)H-Index: 6
#2Tae-Hwan Kim (Korea Research Institute of Bioscience and Biotechnology)H-Index: 47
Last. Jong-Soo Lee (CNU: Chungnam National University)H-Index: 31
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NF-κB essential modulator (NEMO) is a key regulatory protein that functions during NF-κB- and interferon-mediated signaling in response to extracellular stimuli and pathogen infections. Tight regulation of NEMO is essential for host innate immune responses and for maintenance of homeostasis. Here, we report that the E3 ligase MARCH2 is a novel negative regulator of NEMO-mediated signaling upon bacterial or viral infection. MARCH2 interacted directly with NEMO during the late phase of infection a...
1 CitationsSource
#2Myun Soo KimH-Index: 5
Last. Jong-Soo LeeH-Index: 31
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Melia azedarach is commonly used in traditional and folk medicine in Korea and China to treat a variety of diseases including diarrheal, diabetic, rheumatic, and hypertensive disease. The aim of this study was to determine the potential prophylactic and therapeutic effects of Melia azedarach against a broad spectrum of viruses in in vitro cell culture model and the protective effect against different influenza A subtypes in BALB/c mice model. An effective dose of pre-treatment, co-treatment, and...
#1Won Sik Jang (Yonsei University)H-Index: 11
#2Ki Hong Kim (SCH: Soonchunhyang University)H-Index: 10
Last. Dae Keun KimH-Index: 11
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Total motile sperm count is an important parameter for predicting the probability of natural pregnancy. We have externally validated the Samplaski's post-varicocele repair semen analysis nomogram to confirm the predictive accuracy of total motile sperm count. A total of 300 patients who had undergone varicocelectomy between July 2016 and July 2019 from 4 treatment centres were included in this validation cohort study. The predictive performance of the externally validated nomogram was revealed b...
#1Joo Hyung ChoiH-Index: 2
#2Su Hwa YouH-Index: 2
Last. Jong-Hyeon ParkH-Index: 20
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Background The quality of a vaccine depends strongly on the effects of the adjuvants applied simultaneously with the antigen in the vaccine. The adjuvants enhance the protective effect of the vaccine against a viral challenge. Conversely, oil-type adjuvants leave oil residue inside the bodies of the injected animals that can produce a local reaction in the muscle. The long-term immunogenicity of mice after vaccination was examined. ISA206 or ISA15 oil adjuvants maintained the best immunity, prot...
2 CitationsSource
#1Hyo Jin Boo (SMC: Samsung Medical Center)
#2Wooseong Huh (SMC: Samsung Medical Center)H-Index: 23
Last. Jung-Won Hwang (Seoul National University Bundang Hospital)H-Index: 21
view all 9 authors...
#1Jong-Soo LeeH-Index: 31
#2Ji Eun HeoH-Index: 5
Last. Young Deuk ChoiH-Index: 35
view all 6 authors...