Qiang Zhang
Hong Kong Polytechnic University
Self-healing hydrogelsEndothelial stem cellBiophysicsNeuroscienceRegeneration (biology)NanotechnologyChemistryMaterials scienceBiocompatibilityRestenosisDrug deliveryWound healingCoatingBone regenerationTissue engineeringNitric oxideMedicineAdhesionScaffoldNanocomposite
16Publications
8H-index
212Citations
Publications 16
Newest
#1Yue Ma (Jiangsu University)H-Index: 33
#2Peiyan He (Jiangsu University)H-Index: 1
Last. Guoqing Pan (Jiangsu University)H-Index: 33
view all 9 authors...
Simulation of self-recovery and diversity of natural photonic crystal (PC) structures remain great challenges for artificial PC materials. Motivated by the dynamic characteristics of PC nanostructures, here, we present a new strategy for the design of hydrogel-based artificial PC materials with reversible interactions in the periodic nanostructures. The dynamic PC hydrogels, derived from self-assembled microgel colloidal crystals, were tactfully constructed by reversible crosslinking of adjacent...
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#1Yuhe Yang (PolyU: Hong Kong Polytechnic University)H-Index: 4
#2Tianpeng Xu (PolyU: Hong Kong Polytechnic University)H-Index: 1
Last. Xin Zhao (PolyU: Hong Kong Polytechnic University)H-Index: 45
view all 6 authors...
Current periosteal grafts have limitations related to low mechanical strength, tissue adhesiveness, and poor osteogenesis and angiogenesis potential. Here, a periosteum mimicking bone aid (PMBA) with similar structure and function to natural periosteum is developed by electrospinning photocrosslinkable methacrylated gelatin (GelMA), l-arginine-based unsaturated poly(ester amide) (Arg-UPEA), and methacrylated hydroxyapatite nanoparticles (nHAMA). Such combination of materials enhances the materia...
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#1Zhuoyue Chen (Northwest University (United States))H-Index: 2
#1Zhuoyue Chen (Northwest University (China))H-Index: 17
Last. Fulin Chen (Northwest University (United States))H-Index: 9
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Silk fibroin (SF) is considered biocompatible and biodegradable for osteochondral repair. However, it lacks a bioactive domain for cell adhesion, proliferation and differentiation, limiting its therapeutic efficacy. To revamp SF as a biomimicking and bioactive microenvironment to regulate cell behaviours, we engineered an elastin-like polypeptide (ELP, Val-Pro-Gly-Xaa-Gly) to modify SF fibers via simple and green dehydrothermal (DHT) treatment. Our results demonstrated that the ELP successfully ...
4 CitationsSource
#1Qiang Zhang (PolyU: Hong Kong Polytechnic University)H-Index: 8
#2Yuhe Yang (PolyU: Hong Kong Polytechnic University)H-Index: 4
Last. Xin Zhao (PolyU: Hong Kong Polytechnic University)H-Index: 45
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Abstract Tendon adhesion formation describes the development of fibrotic tissue between the tendon and its surrounding tissues, which commonly occurs as a reaction to injury or surgery. Its impact on function and quality of life varies from negligible to severely disabling, depending on the affected area and extent of adhesion formed. Thus far, treatment options remain limited with prophylactic anti-inflammatory medications and revision surgeries constituting the only tools within the doctors’ a...
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#1Yuhe Yang (PolyU: Hong Kong Polytechnic University)H-Index: 4
#2Qiang Zhang (PolyU: Hong Kong Polytechnic University)H-Index: 8
Last. Xin Zhao (PolyU: Hong Kong Polytechnic University)H-Index: 45
view all 9 authors...
Abstract 3D printing is known as a cost-effective technique that shows huge potential in fabrication of graft substitutes for bone tissue regeneration. However, the tradeoff between 3D printability, mechanical strength and bioactivity of the printed materials (i.e., inks) remains a challenge. In this work, we present a novel photocrosslinkable nanocomposite ink composed of tri-block poly (lactide-co-propylene glycol-co-lactide) dimethacrylate (PmLnDMA, m and n respectively represent the unit len...
4 CitationsSource
#1Bei Ho Pan (PolyU: Hong Kong Polytechnic University)H-Index: 1
#2Qiang Zhang (PolyU: Hong Kong Polytechnic University)H-Index: 8
Last. Xin Zhao (PolyU: Hong Kong Polytechnic University)H-Index: 45
view all 6 authors...
1 CitationsSource
#1Qiufen Tu (Southwest Jiaotong University)H-Index: 18
#2Xin Zhao (PolyU: Hong Kong Polytechnic University)H-Index: 45
Last. Zhilu Yang (Southwest Jiaotong University)H-Index: 26
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Abstract Injury of endothelium is an inevitable consequence of cardiovascular stent implantation, which increases the incidence of in-stent restenosis (ISR) and late stent thrombosis (LST). Rapid and complete re-endothelialization, along with long-term suppression of smooth muscle cells (SMCs) are mandatory to alleviate these complications. To this goal, we designed a multi-functional stent coating, consisting of a vascular endothelial growth factor/CuII-dopamine(VEGF/CuII-DA) complex network fo...
8 CitationsSource
#1Bei Ho Pan (PolyU: Hong Kong Polytechnic University)H-Index: 1
#2Qiang Zhang (PolyU: Hong Kong Polytechnic University)H-Index: 8
Last. Xin Zhao (PolyU: Hong Kong Polytechnic University)H-Index: 45
view all 6 authors...
Scars affect millions of patients worldwide, yet their treatment efficacy and options clinically remain limited. In recent years, increased understanding of scar formation pathways leading to developments in nanotechnology have opened many opportunities for scar detection, prevention, and treatment due to the nanoscale features and therapeutic delivery capabilities of such technologies. Led by nanoparticles (NPs) and nanofibers, these novel strategies can aid in reducing scar contracture, improv...
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#1Xiuling Ji (THU: Tsinghua University)H-Index: 3
#2Yufei Yan (SJTU: Shanghai Jiao Tong University)H-Index: 13
Last. Xin Zhao (PolyU: Hong Kong Polytechnic University)H-Index: 45
view all 8 authors...
Osteoarthritis (OA) is a chronic joint disease resulting from joint inflammation and damage. In this study, we employed a boundary lubricant known as a 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) liposome for loading of an anti-inflammatory drug D-glucosamine sulphate (GAS) to construct a treatment strategy allowing for sustained anti-inflammation and reduced damage. This kind of drug-loaded nanocarrier integrates the anti-inflammatory effect of the GAS and the lubrication ability of DSPC ...
20 CitationsSource
#1Lara Yildirimer (Heidelberg University)H-Index: 2
#2Qiang Zhang (PolyU: Hong Kong Polytechnic University)H-Index: 8
Last. Xin Zhao (PolyU: Hong Kong Polytechnic University)H-Index: 45
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: The central nervous system (CNS) has a highly complex biophysical and biochemical environment. Despite decades of intensive research, it is still an enormous challenge to restore its functions and regenerate lost or damaged CNS tissues. Current treatment strategies remain sub-optimal because of (1) the hostile microenvironment created post CNS injury, and (2) insufficient understanding of the pathophysiology of acute and chronic CNS diseases. Two-dimensional (2D) in vitro models have provided ...
17 CitationsSource