Federica Rotundo
PromoterGeneGene silencingmicroRNACellGene expressionIn vivoDU145DroshaProstate cancerTranscription (biology)Alu elementCancer researchRNA splicingMAPK/ERK pathwayCell growthLong non-coding RNARNAComputational biologyProtein kinase BMicroarray analysis techniquesBiologyCell biology
Publications 3
#1Federica RotundoH-Index: 2
#2Denis CominettiH-Index: 14
Last. Paolo GandelliniH-Index: 25
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The development of novel therapies or the improvement of currently used approaches to treat prostate cancer (PCa), the most frequently diagnosed male tumor in developed countries, is an urgent need. In this regard, the functional characterization of microRNAs, molecules shown to regulate a number of cancer-related pathways, is instrumental to their possible clinical exploitation. Here, we demonstrate the tumor-suppressive role of the so far uncharacterized miR-1272, which we found to be signific...
1 CitationsSource
#1Stefano PercioH-Index: 5
#2Federica RotundoH-Index: 2
Last. Paolo Gandellini (University of Milan)H-Index: 25
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Abstract Although the role of miR-205 has been widely elucidated, the function of its host gene (MIR205HG) is yet to be clarified. We have recently investigated whether this gene is a simple endorsement for miRNA production or it may act independently, demonstrating its action as nuclear long noncoding RNA able to control basal-luminal differentiation in the human prostate context, thus deserving the reannotation as LEADR, Long Epithelial Alu-interacting Differentiation-related RNA. Here, we des...
#1Valentina ProfumoH-Index: 7
#2Barbara ForteH-Index: 2
Last. Paolo GandelliniH-Index: 25
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Though miR-205 function has been largely characterized, the nature of its host gene, MIR205HG, is still completely unknown. Here, we show that only lowly expressed alternatively spliced MIR205HG transcripts act as de facto pri-miRNAs, through a process that involves Drosha to prevent unfavorable splicing and directly mediate miR-205 excision. Notably, MIR205HG-specific processed transcripts revealed to be functional per se as nuclear long noncoding RNA capable of regulating differentiation of hu...
21 CitationsSource