Xiaoting Gao
Shenzhen University
Detection limitBiophysicsVesicleAlkaline phosphataseNanoprobePhotothermal therapyChemistryIn vitroIn vivoRed blood cellBiocompatibilityGastric acidPhotothermal effectCell membraneBone regenerationTissue engineeringBiomarker (medicine)ScaffoldFluorescenceAbsorbance
6Publications
3H-index
36Citations
Publications 5
Newest
#1Chen YangH-Index: 4
#2Xiaoting GaoH-Index: 3
Last. Jing Lin (SZU: Shenzhen University)H-Index: 64
view all 9 authors...
Abstract Although numerous biomaterials are fabricated as scaffolds for the application of tissue engineering, real-time non-invasive monitoring of in vivo bone regeneration is still a big challenge. Especially during early osteogenesis, which is difficult to detect using conventional imaging modalities, such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) due to the limited amount of neo-bone tissue. Herein we report on alkaline phosphatase (ALP)-responsive scaffolds, whi...
Source
#1Xiaoting Gao (SZU: Shenzhen University)H-Index: 3
#2Shanshan Jiang (SZU: Shenzhen University)H-Index: 7
Last. Jing Lin (SZU: Shenzhen University)H-Index: 21
view all 7 authors...
Abstract The development of tumor acidic microenvironment-responsive theranostic agents is a research hotspot. Herein, we developed highly photostable amphiphilic croconium dye-anchored red blood cell membrane vesicle (denoted as LET-5) for tumor pH-responsive near-infrared fluorescence (NIRF) and photoacoustic (PA) duplex imaging-guided photothermal therapy. In tumor acidic microenvironment, both NIRF and PA signals of LET-5 were significantly enhanced and the photothermal effect of LET-5 was a...
1 CitationsSource
#1Gongcheng Ma (SZU: Shenzhen University)H-Index: 6
#2Xiaoting Gao (SZU: Shenzhen University)H-Index: 3
Last. Jing Lin (SZU: Shenzhen University)H-Index: 21
view all 7 authors...
In vivo real-time monitoring gastric acid is of great importance for diagnosis and treatment of gastrointestinal diseases. Herein, we synthesized a pH-responsive photoacoustic (PA) nanoprobe (denoted as LET-4) based on near-infrared (NIR) dye (IR1061) for in vivo photoacoustic imaging (PAI) of gastric acid in living subjects. In the acidic condition, the protonated LET-4 nanoprobe has a strong absorbance peak at 808 nm, followed by a strong PA signal output at 808 nm. The PA808 signal at pH 3 is...
4 CitationsSource
#1Xiaoting Gao (SZU: Shenzhen University)H-Index: 3
#2Gongcheng Ma (SZU: Shenzhen University)H-Index: 6
Last. Jing Lin (SZU: Shenzhen University)H-Index: 64
view all 7 authors...
Alkaline phosphatase (ALP) is distributed widely in living organisms and is an important biomarker closely related to many physiological and pathological processes. However, in vivo real-time detection of ALP remains a significant challenge. Herein, we developed a turn-on molecular probe (denoted as LET-3) to visualize ALP activity in tumor tissues through near-infrared fluorescence (NIRF) and photoacoustic (PA) dual-modal imaging. LET-3, composed of NIR hemicyanine dye (LET-CyOH) and a phosphat...
20 CitationsSource
#1Leli Zeng (SZU: Shenzhen University)H-Index: 18
#2Gongcheng Ma (SZU: Shenzhen University)H-Index: 6
Last. Jing Lin (SZU: Shenzhen University)H-Index: 64
view all 10 authors...
: The detection of Cu2+ in living plants and animals is of great importance for environment monitoring and disease diagnosis. Here, a near-infrared (NIR) turn-on photoacoustic (PA) probe (denoted as LET-2) is developed for Cu2+ detection in living subjects, such as soybean sprouts and mice. The absorbance band of LET-2 shifts from 625 to 715 nm after the interaction with Cu2+ , thus producing strong PA signal output at 715 nm (PA715 ) as an indicator. The PA715 value is increased as a function o...
8 CitationsSource