Shahin Aghamiri
Shahid Beheshti University of Medical Sciences and Health Services
GeneCancerInternal medicineMultiple drug resistanceGenome editingRNA interferenceNanotechnologyChemistrySmall interfering RNAChemotherapyCombination therapyDrug deliveryComputer scienceCancer researchBreast cancerAntimicrobial peptidesComputational biologyMedicineMicrofluidicsBiology
22Publications
5H-index
124Citations
Publications 21
Newest
#1Sepideh Mirzaei (IAU: Islamic Azad University, Science and Research Branch, Tehran)H-Index: 5
#2Mahshid Deldar Abad Paskeh (IAU: Islamic Azad University)
Last. Shahin Aghamiri (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
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The clinical management of bladder cancer (BC) has become an increasing challenge due to high incidence rate of BC, malignant behavior of cancer cells and drug resistance. The non-coding RNAs are considered as key factors involved in BC progression. The long non-coding RNAs (lncRNAs) are RNA molecules and do not encode proteins. They have more than 200 nucleotides in length and affect gene expression at epigenetic, transcriptional and post-transcriptional phases. The lncRNAs demonstrate abnormal...
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#1Yazdan Rahmati (IUMS: Iran University of Medical Sciences)H-Index: 2
#2Yahya Asemani (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 1
Last. Sajad Najafi (Shahid Beheshti University of Medical Sciences and Health Services)
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Circular RNAs (circRNAs) as a new class of non-coding RNAs (ncRNAs) play role in gene regulation in multicellular organisms via various interactions with nucleic acids, proteins and particularly microRNAs. They have been found to be involved in a number of biological functions particularly in regulation of cell cycle, and extracellular interactions. Thus, dysregulation of circRNAs is found to be associated with several human diseases and especially numerous types of cancers. ciRS-7 is an example...
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#1Shahin Aghamiri (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
#2Farshid Zandsalimi (Tehran University of Medical Sciences)H-Index: 3
Last. Hossein Ghanbarian (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 16
view all 11 authors...
Breast cancer is the most common and deadliest cancer in women worldwide. Although notable advances have been achieved in the treatment of breast cancer, the overall survival rate of metastatic breast cancer patients is still considerably low due to the development of resistance to breast cancer chemotherapeutic agents and the non-optimal specificity of the current generation of cancer medications. Hence, there is a growing interest in the search for alternative therapeutics with novel anticance...
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#1Shahin Aghamiri (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
#2Pourya Raee (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 4
Last. Shohreh Farhadi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
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The serious drawbacks of the conventional treatment of pancreatic ductal adenocarcinoma (PDAC) such as nonspecific toxicity and high resistance to chemo and radiation therapy, have prompted the development and application of countless small interfering RNA (siRNA)-based therapeutics. Recent advances in drug delivery systems hold great promise for improving siRNA-based therapeutics and developing a new class of drugs, known as nano-siRNA drugs. However, many fundamental questions, regarding toxic...
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#7Mohammad Taha Ebrahimi (Shahid Beheshti University of Medical Sciences and Health Services)
The critical problems of conventional prostate cancer therapeutic strategies like nonspecific toxicity and multi-drug resistance prompted the development and application of countless nanoparticle-based siRNA therapeutics. The main challenges to siRNA-based therapeutics becoming a new paradigm in the treatment of prostate cancer stem from the lack of safe and effective delivery systems, immune system stimulation, poor knowledge of nano-bio interactions, and limitations concerning designing, manuf...
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#1Hamed Varkaneh Kord (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 1
#2Grant M. Tinsley (TTU: Texas Tech University)H-Index: 18
Last. Azita Hekmatdoost (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 31
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Summary Background & aims Fasting and energy-restricted diets have been evaluated in several studies as a means of improving cardiometabolic biomarkers related to body fat loss. However, further investigation is required to understand potential alterations of leptin and adiponectin concentrations. Thus, we performed a systematic review and meta-analysis to derive a more precise estimate of the influence of fasting and energy-restricted diets on leptin and adiponectin levels in humans, as well as...
5 CitationsSource
#1Hossein GhanbarianH-Index: 16
#2Shahin AghamiriH-Index: 5
Last. Kay-Dietrich WagnerH-Index: 30
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Small double-strand RNA (dsRNA) molecules can activate endogenous genes via an RNA-based promoter targeting mechanism. RNA activation (RNAa) is an evolutionarily conserved mechanism present in diverse eukaryotic organisms ranging from nematodes to humans. Small activating RNAs (saRNAs) involved in RNAa have been successfully used to activate gene expression in cultured cells, and thereby this emergent technique might allow us to develop various biotechnological applications, without the need to ...
1 CitationsSource
#1Mohammad Hassan Sohouli (IUMS: Iran University of Medical Sciences)H-Index: 2
#2Aliakbar Sayyari (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 11
Last. Vihan Moodi (Tehran University of Medical Sciences)H-Index: 2
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BACKGROUND Hyperinsulinaemia is considered as a major risk factor for the development of a myriad of chronic diseases. We examined the association between the dietary insulinaemic potential and the odds of non-alcoholic fatty liver disease (NAFLD) among Iranian adults. METHODS After being subjected to a liver ultrasound, 166 patients with NAFLD and 200 controls were included in the study. The dietary intakes and the physical activity levels of the participants were evaluated using a validated se...
1 CitationsSource
#1Shahin Aghamiri (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
#2Navid Rabiee (Sharif University of Technology)H-Index: 16
Last. Mahdi KarimiH-Index: 25
view all 6 authors...
Abstract The conventional platforms for cell characterization and drug delivery do not match the new precise demands of researchers. Because of numerous advantages like miniaturization, low cost, flexibility, and preciseness, microfluidic systems as robust research tools herald a new era of molecular medicine and drug delivery. A special type of microfluidic system, organ-on-a-chip(s), represents cell biological techniques and microfluidic combination. In this chapter, we have focused on investi...
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#1Mohammad Taha Ebrahimi (Tehran University of Medical Sciences)
#2Ali Jafarpour (Tehran University of Medical Sciences)H-Index: 3
Last. Nima Danaei (Tehran University of Medical Sciences)H-Index: 1
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Aims: The Iranian city of Sari with a green nature has great environmental importance, especially in ecotourism. Thus, the proper management of medical wastes is necessary to maintain a sustainable environment. This study is aimed to determine the quantitative and qualitative wastes in the hospitals of Sari. Materials and Methods: This was a cross-sectional study using a descriptive-analytical approach to analyze the infectious and noninfectious wastes of four hospitals in Sari. The data collect...
1 CitationsSource