Dong-Hee Kim
Daejeon University
Internal medicineCC chemokine receptorsChemokineEndocrinologyCCL17Tumor necrosis factor alphaChemistryImmunologyHouttuynia cordataSaururaceaeCytokineCell cultureBiologyPharmacology
11Publications
7H-index
288Citations
Publications 8
Newest
#1Eun Ju Yang (Eulji University)H-Index: 10
#2Eugene Choi (Konyang University)H-Index: 4
Last. In Sik Kim (Eulji University)H-Index: 17
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In this study, we investigated the effects of CCL2 on constitutive apoptosis of normal and asthmatic neutrophils. CCL2 blocked the constitutive apoptosis of normal neutrophils through CCR2. CCL2 also induced elevation of the cytosolic Ca2+ concentration but had no effect on normal neutrophil chemotaxis. Constitutive apoptosis, calcium influx, and cell migration of asthmatic neutrophils were not affected by CCL2 stimulation. Supernatant collected from CCL2-treated normal neutrophils inhibited the...
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#1Dae Sik JangH-Index: 30
#2Ga Young LeeH-Index: 3
Last. Jin Sook KimH-Index: 35
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Two new flavan-3-ols, 6-(2-pyrrolidinone-5-yl)-(-)-epicatechin (1) and 8-(2-pyrrolidinone-5-yl)-(-)-epicatechin (2), as well as five known compounds, (-)-epicatechin (3), (+)-catechin (4), proanthocyanidin B-4 (5), (+)-pinoresinol, and p-hydroxybenzoic acid, were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation, particularly by extensive 1D- and 2D-NMR studies. All the isolates were e...
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#1Eun Ju Yang (Eulji University)H-Index: 10
#2Ji-Sook Lee (UPR-RP: UPRRP College of Natural Sciences)H-Index: 18
Last. In Sik Kim (Eulji University)H-Index: 17
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Ethnopharmacological relevance Duchesnea chrysantha (D. chrysantha) is a herb with anti-oxidative, anti-inflammatory and immune-enhancing properties. Aim of the study Asthma is an inflammatory disease of the lungs, and the hallmarks of the disease are increased inflammatory cell infiltration into the airways and poor respiratory function. Although there is the possibility that D. chrysantha may have an inhibitory effect on lung inflammation, the effects of D. chrysantha on asthma have not been f...
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#1Ji-Sook Lee (Daejeon University)H-Index: 18
#2In Sik Kim (Eulji University)H-Index: 17
Last. Chi-Young Yun (Daejeon University)H-Index: 13
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Abstract Ethnopharmacological relevance Houttuynia cordata Thunb (Saururaceae), known as ‘E-Sung-Cho’ in Korea, has been traditionally used for the treatment of herpes simplex, chronic sinusitis, and allergy. Aim of the study To investigate the inhibitory activity of Houttuynia cordata Thunb fractions (HcFs) on the T helper 2 (Th2) immune response, we evaluated the alternation of the release of Th2-type cytokines and chemokines such as interleukin (IL)-4 and IL-5, and thymus and activation-regul...
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#1In Sik Kim (Eulji University)H-Index: 17
#2Joo-Hwan Kim (UPR-RP: UPRRP College of Natural Sciences)H-Index: 23
Last. Ji-Sook Lee (UPR-RP: UPRRP College of Natural Sciences)H-Index: 18
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Abstract Hottuynia cordata Thunb (Saururaceae; HC) is known as a therapeutic drug that has been used in traditional oriental medicine for the treatment of allergy. Mast cells play an important role in a variety of inflammatory diseases, and specifically asthma and atopy. In the present study, we investigated the effect of HC extracts on the migration of the human mast cell line, HMC-1, in response to stem cell factor (SCF). Treatment with HC extracts at a concentration of 10 μg/ml for 24 h showe...
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#1Chan-Sik KimH-Index: 24
#2Eun Jin SohnH-Index: 17
Last. Jin Sook KimH-Index: 35
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Abstract We investigated the effect of KIOM-79, 80% ethanolic extract of a new herbal prescription, on non-obese type 2 diabetic Goto-Kakizaki (GK) rats. The rats were treated orally with KIOM-79 (500 mg/kg body weight) once a day for 13 weeks to examine the long-term effects on hyperglycemia and glomerular histology as well as biochemical and functional abnormalities in kidney. As the results, we found that KIOM-79 reduced hyperglycemia ( p p p p p p p p p
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#1Jesang Ko (KU: Korea University)H-Index: 21
#2Chi Young Yun (UPR-RP: UPRRP College of Natural Sciences)H-Index: 1
Last. In Sik Kim (Eulji University)H-Index: 17
view all 6 authors...
Abstract Mast cells are well known as effector cells in a variety of inflammatory diseases, including asthma as well as other allergic disorders. The precise role of 9-cis retinoic acid (9CRA) in mast cells is not understood despite the accepted fact that 9CRA regulates inflammatory responses and neutrophil differentiation. In this study, we investigated the effects of 9CRA on the expression of CC chemokine receptors in the human mast cell line, HMC-1. 9CRA selectively inhibits the CCR2 mRNA lev...
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#1Ji-Sook Lee (Daejeon University)H-Index: 18
#2In Sik Kim (Eulji University)H-Index: 17
Last. Chi-Young Yun (Daejeon University)H-Index: 13
view all 4 authors...
Abstracts Allergic inflammation is thought to be a Th2 cell‐dominant immune response during which tissue‐resident fibroblasts produce chemokines which contribute to the recruitment of migratory leukocytes to sites of tissue injury. Thymus and activation‐regulated chemokine (TARC; CCL17) is a potent member of the CC chemokine family and a selective chemoattractant for Th2 cells. In order to study the regulatory profiles of TARC production by TNF‐α, IFN‐γ, and IL‐4 in human normal skin fibroblast,...
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