McKenna E. Williams
San Diego State University
RecallNonparametric statisticsVerbal memoryParametric statisticsCognitive Assessment SystemInternal medicineSample size determinationNeuropsychologyMagnetic resonance imagingOncologyPsychologyTwin studyCognitionCognitive psychologyMnemonicYoung adultMontreal Cognitive AssessmentNeurodegenerationLongitudinal studySleep apneaLocus coeruleusSpatial abilityDepression (differential diagnoses)DiseaseDementiaParkinson's diseaseMiddle ageBody mass indexHuntington's diseaseHistory of depressionMotor dysfunctionSpatial similarityCognitive impairmentParametric methodsCognitive changeGroup differencesSignificant groupMemory impairmentMemory taskAge relatedSubstance abuseIncidence (epidemiology)StrokeMedical diagnosisClinical trialAudiologyNeuroimagingCognitive testCognitive reserveClinical psychologyMedicineBiomarker (medicine)California Verbal Learning TestCued speechEpisodic memorySimilarity (network science)Recognition memoryVerbal fluency test
13Publications
1H-index
6Citations
Publications 11
Newest
#1Lisa V. Graves (SDSU: San Diego State University)H-Index: 4
#2Stephanie M. Simone (UCSD: University of California, San Diego)
Last. Paul E. Gilbert (SDSU: San Diego State University)H-Index: 32
view all 11 authors...
: The original and second editions of the California Verbal Learning Test (CVLT) used nonparametric and parametric methods, respectively, to assess Total Recognition Discriminability (RD). In a previous study, we found evidence that the nonparametric formula may be more sensitive than the parametric formula to high false positive (FP) rates and provide more accurate assessments of yes/no recognition in neurodegenerative populations prone to high FP rates, including Alzheimer's disease (AD). In t...
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#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Olivia K. Puckett (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
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INTRODUCTION The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression. METHODS Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LCCNR ). We examined LCCNR , cognition, amnestic mild cognitive imp...
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#1Hillary L Ditmars (BU: Boston University)H-Index: 1
#2Mark W. Logue (BU: Boston University)H-Index: 33
Last. Michael J. Lyons (BU: Boston University)H-Index: 85
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Background Clarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated with the subsequent onset of cardiometabolic health problems. Methods The study sample comprised 787 male twin veterans with polygenic risk score data who participated in the Harvard Twin Study of Substance Abuse ('baseline') and the longitudinal V...
1 CitationsSource
#1Jody Corey-Bloom (UCSD: University of California, San Diego)H-Index: 61
#2McKenna E. Williams (SDSU: San Diego State University)H-Index: 1
Last. Paul E. Gilbert (SDSU: San Diego State University)H-Index: 32
view all 9 authors...
Background Several studies have suggested that cognitive processing speed may be useful for assessing early cognitive change in premanifest Huntington's disease (HD); however, current measures lack the ability to control for the effects of motor dysfunction commonly found in HD. The Computerized Test of Information Processing (CTiP) is a rapidly administered computerized tool that allows for the examination of central cognitive processing speed by using motor-corrected scores to account for moto...
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#1Graham M.L. Eglit (UCSD: University of California, San Diego)H-Index: 7
#2Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
Last. William S. KremenH-Index: 70
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#1William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
#2Mark Sanderson-Cimino (SDSU: San Diego State University)H-Index: 6
Last. Carol E. Franz (UCSD: University of California, San Diego)H-Index: 48
view all 15 authors...
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#1McKenna E. Williams (UCSD: University of California, San Diego)
#1McKenna E. Williams (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 13 authors...
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#1Mark Sanderson-Cimino (UCSD: University of California, San Diego)H-Index: 1
#2Jeremy A. Elman (University of California, Berkeley)H-Index: 15
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Objective Practice effects on cognitive tests obscure decline, thereby delaying detection of mild cognitive impairment (MCI). This reduces opportunities for slowing Alzheimer's disease progression and can hinder clinical trials. Using a novel method, we assessed the ability of practice-effect-adjusted diagnoses to detect MCI earlier, and tested the validity of these diagnoses based on AD biomarkers. Methods Of 889 Alzheimer's Disease Neuroimaging Initiative participants who were cognitively norm...
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#1McKenna E. Williams (SDSU: San Diego State University)H-Index: 1
#2Lisa V. Graves (UCSD: University of California, San Diego)H-Index: 4
Last. Paul E. Gilbert (UCSD: University of California, San Diego)H-Index: 32
view all 9 authors...
Although age-related memory differences between young and older adults have been well documented, fewer studies have investigated memory changes in middle age. We examined the performance of healthy middle-aged adults (40-55 years of age; n = 32) in relation to healthy young (18-25 years of age; n = 57) and older adults (65+ years of age; n = 55) on variations of recognition discriminability (RD) indices derived from the California Verbal Learning Test-Second Edition (CVLT-II). Middle-aged adult...
1 CitationsSource
#1McKenna E. Williams (SDSU: San Diego State University)H-Index: 1
#2Lisa V. Graves (UCSD: University of California, San Diego)H-Index: 4
Last. Paul E. Gilbert (SDSU: San Diego State University)H-Index: 32
view all 6 authors...
: Spatial memory impairment is well documented in old age; however, less is known about spatial memory during middle age. We examined the performance of healthy young, middle-aged, and older adults on a spatial memory task with varying levels of spatial similarity (distance). On low similarity trials, young adults significantly outperformed middle-aged adults, who significantly outperformed older adults (Ps < 0.05). On high similarity trials, young adults significantly outperformed middle-aged a...
3 CitationsSource