Zhen Ao
China Pharmaceutical University
Chirality (chemistry)Circular dichroismVimentinChemistryAbsolute configurationRing (chemistry)PeroxideHypericum patulumInhibitory effectIc50 valuesBinding pocketStereochemistry
4Publications
2H-index
17Citations
Publications 4
Newest
#1Yang-Yang Liu (CPU: China Pharmaceutical University)H-Index: 2
#2Zhen Ao (CPU: China Pharmaceutical University)H-Index: 2
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
view all 8 authors...
Source
#1Zhen Ao (CPU: China Pharmaceutical University)H-Index: 2
#2Yang-Yang Liu (CPU: China Pharmaceutical University)H-Index: 2
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
view all 7 authors...
Abstract Hyperpatulones A (1) and B (2), two new polycyclic polyprenylated acylphloroglucinols (PPAPs), were isolated from the leaves of Hypericum patulum. Their unusual 6,7,5-tricyclic system with a peroxide bridge structures were elucidated by comprehensive analysis of their spectroscopic and HRESIMS data. The absolute configuration of hyperpatulone A was determined by comparison between experimental and calculated electron circular dichroism (ECD) spectra. Compounds 1 and 2 exhibited moderate...
2 CitationsSource
#1Yang-Yang Liu (CPU: China Pharmaceutical University)H-Index: 2
#2Zhen Ao (CPU: China Pharmaceutical University)H-Index: 2
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
view all 8 authors...
Abstract Nine new spirocyclic acylphloroglucinol derivatives, hyperpatulols A–I (1–9), were characterized from the flowers of Hypericum patulum. Their structures were elucidated by the basic analysis of the obtained spectroscopic data, and their absolute configurations were assigned by both the electronic circular dichroism (ECD) exciton chirality method and ECD calculation. The evaluation of their anti-migration effects on U2-OS human osteosarcoma cells showed that compound 4 exhibited moderate...
8 CitationsSource
#1Yang-Yang Liu (CPU: China Pharmaceutical University)H-Index: 2
#2Zhen Ao (CPU: China Pharmaceutical University)H-Index: 2
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
view all 6 authors...
Hypatulone A (1), an acylphloroglucinol possessing an unprecedented homoadamantane architecture based on a tricyclo-[4.3.1.13,8]-undecane core and a unique 5/5/7/6/6 pentacyclic ring system, together with its biogenetic precursor hyperbeanol B (2), was isolated from Hypericum patulum. The structure of 1 was elucidated by extensive spectroscopic analysis and electronic circular dichroism calculation. Its plausible biosynthetic pathway via Wagner–Meerwein rearrangement was proposed. 1 exhibited ni...
17 CitationsSource