Pengcheng Qiu
High-performance liquid chromatographyAqueous solutionChemistryMethanesulfonic acidAcetonitrileForced degradationLisdexamfetamine DimesylateChromatographyLiquid chromatography–mass spectrometryImpurity
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#3Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
Twelve impurities (process-related and degradation) in lisdexamfetamine dimesylate (LDX), a central nervous system (CNS) stimulant drug, were first separated and quantified by high-performance liquid chromatography (HPLC) and then identified by liquid chromatography mass spectrometry (LC-MS). The structures of the twelve impurities were further confirmed and characterized by IR, HRMS and NMR analyses. Based on the characterization data, two previously unknown impurities formed during the process...
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