Sheng-Hua Gao
High-performance liquid chromatographyAqueous solutionChemistryCombinatorial chemistryMethanesulfonic acidAcetonitrileForced degradationLacosamideLisdexamfetamine DimesylateAntiepileptic drugChromatographyLiquid chromatography–mass spectrometryImpurity
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#1Meng-Di Chen (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2An-Jiang YangH-Index: 1
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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An efficient synthesis process of an antiepileptic drug, lacosamide, with high chiral purity has been developed. A series of acids were screened to form salts with the key intermediate 4, and phosphoric acid, an inexpensive and achiral reagent, turned out to be the best counterion, which could enhance both chemical purity and chiral purity of the key intermediate 4. 4-Phosphate was used for the successful synthesis of lacosamide with high chemical and chiral purities.
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#1Sheng-Hua GaoH-Index: 1
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Twelve impurities (process-related and degradation) in lisdexamfetamine dimesylate (LDX), a central nervous system (CNS) stimulant drug, were first separated and quantified by high-performance liquid chromatography (HPLC) and then identified by liquid chromatography mass spectrometry (LC-MS). The structures of the twelve impurities were further confirmed and characterized by IR, HRMS and NMR analyses. Based on the characterization data, two previously unknown impurities formed during the process...
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