Lili Meng
High-performance liquid chromatographyAqueous solutionChemistryMethanesulfonic acidAcetonitrileForced degradationLisdexamfetamine DimesylateChromatographyLiquid chromatography–mass spectrometryImpurity
Publications 1
#1Sheng-Hua GaoH-Index: 1
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Twelve impurities (process-related and degradation) in lisdexamfetamine dimesylate (LDX), a central nervous system (CNS) stimulant drug, were first separated and quantified by high-performance liquid chromatography (HPLC) and then identified by liquid chromatography mass spectrometry (LC-MS). The structures of the twelve impurities were further confirmed and characterized by IR, HRMS and NMR analyses. Based on the characterization data, two previously unknown impurities formed during the process...