Justyna Wozniak
RWTH Aachen University
Loss functionMatrix metalloproteinaseLigand (biochemistry)Downregulation and upregulationChemokineCXCL16Innate immune systemCleavage (embryo)InternalizationPathologyMembrane proteinCellPhagocytosisProinflammatory cytokineHomology (biology)EndogenyReceptorGene knockdownHepatic stellate cellTumor necrosis factor alphaProteasesChemistrySmall hairpin RNAIn vitroIn vivoIn silicoProteaseInflammationSAPS IIVascular diseaseCoronary artery diseaseDisintegrinOrgan dysfunctionKidney diseaseCytokineADAM10Epidermal growth factor receptorSteatohepatitisADAM8Stem cellIntracellular vesicleBreast cancer metastasisAmyloid precursor protein secretaseMyocardial infarctionCancer researchMetalloproteinaseSecretory pathwayInterleukin 8Text miningMedicineCX3CL1Immune systemCell biology
7Publications
3H-index
17Citations
Publications 7
Newest
#1Stefan Düsterhöft (RWTH Aachen University)H-Index: 11
#2Selcan Kahveci-Türköz (RWTH Aachen University)
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 35
view all 14 authors...
Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17. Yet, the structural and functional requirements to promote the transport of the iRhom-ADAM17 complex have not yet been thoroughly investigated. Utilising in silico and in vitro methods, we here map the conserved iRhom homology domain (IRHD) and pr...
Source
#1Justyna Wozniak (RWTH Aachen University)H-Index: 3
#2Jürgen Floege (RWTH Aachen University)H-Index: 100
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 4 authors...
Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs) belong to the metzincin family of zinc-containing multidomain molecules, and can act as soluble or membrane-bound proteases. These enzymes inactivate or activate other soluble or membrane-expressed mediator molecules, which enables them to control developmental processes, tissue remodelling, inflammatory responses and proliferative signalling pathways. The dysregulation of MMPs and ADAMs has long been recognized in...
2 CitationsSource
#1Tanzeela Awan (RWTH Aachen University)H-Index: 1
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 8
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 10 authors...
Acute and chronic liver inflammation is driven by cytokine and chemokine release from various cell types in the liver. Here, we report that the induction of inflammatory mediators is associated with a yet undescribed upregulation of the metalloproteinase ADAM8 in different murine hepatitis models. We further show the importance of ADAM8 expression for the production of inflammatory mediators in cultured liver cells. As a model of acute inflammation, we investigated liver tissue from lipopolysacc...
Source
#1Anke Seifert (RWTH Aachen University)H-Index: 3
#2Stefan Düsterhöft (RWTH Aachen University)H-Index: 11
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 10 authors...
The metalloproteinase ADAM10 critically contributes to development, inflammation, and cancer and can be controlled by endogenous or synthetic inhibitors. Here, we demonstrate for the first time that loss of proteolytic activity of ADAM10 by either inhibition or loss of function mutations induces removal of the protease from the cell surface and the whole cell. This process is temperature dependent, restricted to mature ADAM10, and associated with an increased internalization, lysosomal degradati...
3 CitationsSource
#1Anke Seifert (RWTH Aachen University)H-Index: 3
#2Justyna Wozniak (RWTH Aachen University)H-Index: 3
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 9 authors...
Uptake of bacteria by phagocytes is a crucial step in innate immune defence. Members of the disintegrin and metalloproteinase (ADAM) family critically control the immune response by limited proteolysis of surface expressed mediator molecules. Here, we investigated the significance of ADAM17 and its regulatory adapter molecule iRhom2 for bacterial uptake by phagocytes. Inhibition of metalloproteinase activity led to increased phagocytosis of pHrodo labelled Gram-negative and -positive bacteria (E...
3 CitationsSource
#1Daniel Schick (RWTH Aachen University)H-Index: 2
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 8
Last. Daniela Dreymueller (Saarland University)H-Index: 16
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Abstract Background and aims Members of the family of a disintegrin and metalloproteinases (ADAMs) and their substrates have been previously shown to modulate the inflammatory response in cardiac diseases, but studies investigating the relevance of ADAM8 are still rare. Our aim is to provide evidence for the inflammatory dysregulation of ADAM8 in vascular diseases and its association with disease severity. Methods Western-type diet fed Apoe−/− and Ldlr−/− mice and artery ligation served as murin...
6 CitationsSource
#1Justyna Wozniak (RWTH Aachen University)H-Index: 3
#2Andreas Ludwig (RWTH Aachen University)H-Index: 63
7 CitationsSource