Qi-Qi Xu
China Pharmaceutical University
CytotoxicityTautomerChirality (chemistry)StereoisomerismCircular dichroismMultiple drug resistanceStereocenterVimentinHigh-content screeningMass spectrometryHigh-performance liquid chromatographyEnzymeChemistryTwo-dimensional nuclear magnetic resonance spectroscopyAcetophenoneSalvia miltiorrhizaWestern blotEnolIC50MelicopeMedicinal plantsCongenerSnailAnnonaceaeDoxorubicinDemethylaseProtein Tyrosine Phosphatase 1BXylopia vielanaSalvianolic acid BHypericum patulumMigration AssayIc50 valuesChromatographyEnantiomerBiochemistryCountercurrent chromatographyNuclear magnetic resonance spectroscopyStereochemistryElutionDrug discoveryResolution (mass spectrometry)Cancer cell
7Publications
4H-index
24Citations
Publications 7
Newest
#1Qi-Qi Xu (CPU: China Pharmaceutical University)H-Index: 4
#2Chao Zhang (CPU: China Pharmaceutical University)H-Index: 21
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
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The transcriptional repressor Snail trriggers epithelial-mesenchymal transition (EMT), the process allowing cancer cells with invasive and metastasis properties. In this study, we screened medicinal plants for the Snail inhibitory active components by high content screen (HCS) and found that the crude extract of Xylopia vielana leaves showed potential activity. Subsequently, bioassay-guided isolation of the extract of Xylopia vielana was performed to obtain twenty-four dimeric guaianes (1-24), i...
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#1Yang-Yang Liu (CPU: China Pharmaceutical University)H-Index: 2
#2Zhen Ao (CPU: China Pharmaceutical University)H-Index: 2
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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#1Yaolan Lin (CPU: China Pharmaceutical University)H-Index: 5
#2Chao Han (CPU: China Pharmaceutical University)H-Index: 11
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Abstract The ability to separate bioactive compounds from herbal medicines, which contain abundant components, is crucial for drug discovery. Conventional Countercurrent chromatography (CCC) methods for separating bioactive compounds are labor intensive and show low efficiency. Here, we present a novel integrative CCC method for separating lysine-specific demethylase 1 (LSD1) inhibitors from the roots of Salvia miltiorrhiza (RSM). The methanol extracts of RSM were separated into hydrosoluble and...
5 CitationsSource
#1Yang-Yang Liu (CPU: China Pharmaceutical University)H-Index: 2
#2Zhen Ao (CPU: China Pharmaceutical University)H-Index: 2
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Abstract Nine new spirocyclic acylphloroglucinol derivatives, hyperpatulols A–I (1–9), were characterized from the flowers of Hypericum patulum. Their structures were elucidated by the basic analysis of the obtained spectroscopic data, and their absolute configurations were assigned by both the electronic circular dichroism (ECD) exciton chirality method and ECD calculation. The evaluation of their anti-migration effects on U2-OS human osteosarcoma cells showed that compound 4 exhibited moderate...
8 CitationsSource
#1Jin-Fang Xu (CPU: China Pharmaceutical University)H-Index: 6
#2Chao Han (CPU: China Pharmaceutical University)H-Index: 11
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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A synthesis-inspired chemical investigation of the leaves of Melicope ptelefolia led to the isolation of evodialones A–D (1–4), four rearranged acetophenone stereoisomers possessing a prenylated acylcyclopentenone skeleton with three stereogenic carbons. Evodialones C and D (3 and 4) are new minor constituents. The chiral-phase HPLC resolution gave (+)-1–4 and (−)-1–4, eight enantiomers forming a complete stereoisomer library. Their absolute configurations were elucidated via extensive spectrosc...
4 CitationsSource
#1Ya-Long Zhang (CPU: China Pharmaceutical University)H-Index: 9
#2Qi-Qi Xu (CPU: China Pharmaceutical University)H-Index: 4
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Abstract Thirteen undescribed dimeric guaianes were isolated from the leaves of Xylopia vielana Pierre. Their structures were elucidated by NMR spectroscopy and mass spectrometry, and the absolute configurations of vielanins G-Q were determined by a combination of the circular dichroism (CD) exciton chirality method, chemical conversion, and electronic CD (ECD) spectroscopy analysis. Vielaninors A and B are the first examples of trinor-guaiane-dimers. Multidrug resistance reversal activity assay...
8 CitationsSource
#1Qi-Qi Xu (CPU: China Pharmaceutical University)H-Index: 4
#2Xin-lin Chen (CPU: China Pharmaceutical University)H-Index: 3
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Abstract Five new prenylated acetophenones, melicoptelins A-E (1–5), along with one known congener (6) were isolated from the roots of Melicope ptelefolia. Among them, compounds 2a/2b, 3a/3b, and 4a/4b were obtained as inseparable interconverting mixtures of keto and enol tautomers. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D, 2D NMR and HRESIMS. Compouds 2a/2b, 4a/4b and 5 exhibit protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with...
4 CitationsSource