Mina Kim
UCL Institute of Neurology
Fluid-attenuated inversion recoveryMotion (physics)Bayesian probabilityPhysicsBiomedical engineeringSaturation (chemistry)Magnetic resonance imagingHyperintensityRepeatabilityGaussianEndogenySaturation (magnetic)ChemistryBiological systemField strengthField (physics)Materials scienceRange (statistics)In vivoProstateGrey matterScannerProstate cancerLesionWhite matterMagnetization transferGlucose InjectionChemical Exchange Saturation Transfer MRISignal SensitivityFitting algorithmNuclear medicineRelaxation rateGlucose infusionSaturation transferWater saturationChemical exchangeTherapy responseSignificant differenceGradient echoBody regionCest mriMathematicsComputer sciencePercentage pointNuclear magnetic resonanceCancer researchStatistical significanceSubtractionText miningMedicineBiomarker (medicine)Pulse (signal processing)Coefficient of variationReduction (complexity)
Publications 6
#1Mina Kim (UCL: University College London)H-Index: 3
#2Aaron Kujawa (UCL: University College London)H-Index: 3
Last. Xavier Golay (UCL: University College London)H-Index: 60
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PURPOSE: To translate the recently developed PRO-QUEST (Progressive saturation for quantifying exchange rates using saturation times) sequence from preclinical 9.4T to 3T clinical magnetic field strength. METHODS: Numerical simulations were performed to define the optimal saturation flip angles for PRO-QUEST saturation pulses at 3T and demonstrate the effect of a T2 error on the exchange rate (kex ) estimation at various field strengths. Exchange-dependent relaxation rate (Rex ) was measured for...
1 CitationsSource
#1Sachi Okuchi (UCL: University College London)H-Index: 1
#1Sachi OkuchiH-Index: 3
Last. Stefanie ThustH-Index: 7
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Chemical exchange saturation transfer can be further developed as a biomarker for metabolically active brain tumors, evidenced by correlations to tissue findings, including proliferative indexes; f...
#1Mina Kim (UCL: University College London)H-Index: 3
#2F Torrealdea (UCLH: University College Hospital)H-Index: 1
Last. Xavier GolayH-Index: 60
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Background: The aim of this study was to translate dynamic glucose enhancement (DGE) body magnetic resonance imaging (MRI) based on the glucose chemical exchange saturation transfer (glucoCEST) signal to a 3 T clinical field strength. Methods: An infusion protocol for intravenous (i.v.) glucose was optimised using a hyperglycaemic clamp to maximise the chances of detecting exchange-sensitive MRI signal. Numerical simulations were performed to define the optimum parameters for glucoCEST measureme...
6 CitationsSource
#1Vincent Evans (UCL: University College London)H-Index: 2
#2F. J. Torrealdea (UCL: University College London)H-Index: 9
Last. David Atkinson (UCL: University College London)H-Index: 68
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BACKGROUND: Chemical exchange saturation transfer (CEST) can potentially support cancer imaging with metabolically derived information. Multiparametric prostate MRI has improved diagnosis but may benefit from additional information to reduce the need for biopsies. PURPOSE: To optimize an acquisition and postprocessing protocol for 3.0 T multipool CEST analysis of prostate data and evaluate the repeatability of the technique. STUDY TYPE: Prospective. SUBJECTS: Five healthy volunteers (age range: ...
7 CitationsSource
#1Aaron Kujawa (UCL: University College London)H-Index: 3
#2Mina Kim (UCL: University College London)H-Index: 3
Last. Xavier Golay (UCL: University College London)H-Index: 5
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Abstract Fitting a model based on the Bloch-McConnell (BM) equations to Chemical Exchange Saturation Transfer (CEST) spectra allows for the quantification of metabolite concentration and exchange rate as well as simultaneous correction of field inhomogeneity, direct water saturation and magnetization transfer. Employing a Bayesian fitting approach permits the integration of prior information into the analysis to incorporate expected parameter distributions and to prevent over-fitting. However, t...
3 CitationsSource
#1Moritz Zaiss (MPG: Max Planck Society)H-Index: 28
#2Kai Herz (MPG: Max Planck Society)H-Index: 8
Last. Klaus Scheffler (MPG: Max Planck Society)H-Index: 76
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Abstract Purpose Dynamic CEST studies such as dynamic glucose enhanced imaging, have gained a lot of attention recently. The expected CEST effects after injection are rather small in tissue especially at clinical field strengths (0.5–2%). Small movements during the dynamic CEST measurement together with a subtraction-based evaluation can lead to pseudo CEST effects of the same order of magnitude. These artifacts are studied herein. Methods A brain tumor patient 3D-CEST baseline scan without gluc...
21 CitationsSource