Michele Cicala
Università Campus Bio-Medico
Internal medicineEndocrinologySurgeryChemistryImmunologyGERDInfliximabGallbladderNerdAsymptomaticInflammatory bowel diseaseIrritable bowel syndromeHigh resolution manometryDiseaseCrohn's diseaseIn patientRefluxMedicineBiologyGastroenterology
284Publications
35H-index
3,032Citations
Publications 286
Newest
#1Mentore Ribolsi (Università Campus Bio-Medico)H-Index: 21
#2Marzio FrazzoniH-Index: 33
Last. Edoardo Savarino (UNIPD: University of Padua)H-Index: 63
view all 5 authors...
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#6Donald O. Castell (MUSC: Medical University of South Carolina)H-Index: 100
Objective Limitations of existing impedance-pH thresholds include small sample size of normative studies, inclusion of artefactual pH drops and incorrect identification of impedance reflux events. We aimed to obtain new impedance-pH thresholds from expert consensus analysis of tracings from a large number of healthy subjects. Design Of 541 studies performed worldwide using two different systems (Diversatek, USA, and Laborie, Netherlands), 150 tracings with oesophageal diagnoses, behavioural diso...
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#1Mentore Ribolsi (Università Campus Bio-Medico)H-Index: 21
Last. Michele CicalaH-Index: 35
view all 7 authors...
INTRODUCTION The clinical management of chronic cough patients is challenging, and their response to proton pump inhibitors (PPIs) is considered as unsatisfactory. Few data concerning the association between impedance-pH variables and PPI response in these patients are available. Mean nocturnal baseline impedance (MNBI) and postreflux swallow-induced peristaltic wave (PSPW) index increase the diagnostic yield of impedance-pH in gastroesophageal reflux disease. METHODS Demographic, clinical, and ...
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#1Mentore Ribolsi (Università Campus Bio-Medico)H-Index: 21
#2Marzio FrazzoniH-Index: 33
Last. Edoardo Savarino (UNIPD: University of Padua)H-Index: 63
view all 9 authors...
BACKGROUND The Lyon Consensus delineates impedance-pH parameters that can demonstrate/exclude gastro-oesophageal reflux disease (GERD). In patients with acid exposure time between 4% and 6%, GERD diagnosis has been considered inconclusive. In these cases, mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index may either confirm or refute GERD diagnosis and represent predictors of proton pump inhibitor (PPI) response. AIMS To investigate the diagnos...
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#1Mentore Ribolsi (Università Campus Bio-Medico)H-Index: 21
#2Marzio FrazzoniH-Index: 33
Last. Edoardo Savarino (UNIPD: University of Padua)H-Index: 63
view all 11 authors...
BACKGROUND Esophageal chemical clearance has been evaluated with the post-reflux swallow-induced peristaltic wave (PSPW) index. The factors triggering PSPW in Gastro-esophageal reflux disease (GERD) have not yet been investigated. This multicenter study was aimed at evaluating the characteristics of reflux episodes associated with PSPW occurrence in patients with typical GERD symptoms. METHODS Impedance-pH tracings from patients with typical reflux symptoms were analyzed. Sixteen healthy subject...
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#1Mentore Ribolsi (Università Campus Bio-Medico)H-Index: 21
#2Edoardo Savarino (UNIPD: University of Padua)H-Index: 63
Last. C. Prakash Gyawali (WashU: Washington University in St. Louis)H-Index: 31
view all 8 authors...
Background/Aims The role of esophageal high-resolution manometry (HRM) within Lyon consensus phenotypes, especially patients with inconclusive gastroesophageal reflux disease (GERD) evidence, has not been fully investigated. In this multicenter, observational study we aim to compare HRM parameters in patients with GERD stratified according to the Lyon consensus. Methods Clinical and endoscopic data, HRM and multichannel intraluminal impedance-pH (MII-pH) studies performed off proton pump inhibit...
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#1Giovanni Palombo (National Research Council)H-Index: 5
#2Mario Merone (Università Campus Bio-Medico)H-Index: 8
Last. Vincenzo Piemonte (Università Campus Bio-Medico)H-Index: 23
view all 11 authors...
BackgroundThe totality of bacteria, protozoa, viruses and fungi that lives in the human body is called microbiota. Human microbiota specifically colonizes the skin, the respiratory and urinary tract, the urogenital tract and the gastrointestinal system. This study focuses on the intestinal microbiota to explore the drug-microbiota relationship and, therefore, how the drug bioavailability changes in relation to the microbiota biodiversity to identify more personalized therapies, with the minimum ...
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#1Marzio FrazzoniH-Index: 33
#2Leonardo FrazzoniH-Index: 24
Last. Edoardo SavarinoH-Index: 63
view all 10 authors...
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#1Annamaria Altomare (Università Campus Bio-Medico)H-Index: 17
#2Claudia Di Rosa (Università Campus Bio-Medico)H-Index: 4
Last. Michele Pier Luca Guarino (Università Campus Bio-Medico)H-Index: 24
view all 6 authors...
Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain associated with defecation or a change in bowel habits. Gut microbiota, which acts as a real organ with well-defined functions, is in a mutualistic relationship with the host, harvesting additional energy and nutrients from the diet and protecting the host from pathogens; specific alterations in its composition seem to play a crucial role in IBS pathophysiology. It is well known that ...
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#1Annamaria Altomare (Università Campus Bio-Medico)H-Index: 17
#2Federica Del Chierico (Boston Children's Hospital)H-Index: 27
Last. Michele Pier Luca Guarino (Università Campus Bio-Medico)H-Index: 24
view all 15 authors...
Intestinal dysbiosis seems to play a role in the pathophysiology of irritable bowel syndrome (IBS). The present pilot study aimed to elucidate the association between nutrient intake and Mediterranean diet (MD) adherence with IBS symptoms and gut microbiota in IBS patients. The nutrient intake of 28 IBS patients and 21 controls was assessed through a food diary, the reference intake ranges (RIs) for energy-yielding macronutrients and the MD serving score (MDSS) index. MD adherence and nutrients ...
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