Xin Shu
Jilin University
I?B kinaseCitrate synthaseAdipogenesisInternal medicinePeroxisomeEndocrinologyLipolysisLipogenesisXanthine dehydrogenaseWhite adipose tissueAdipose tissueChemistryLipid dropletSuperoxide dismutaseOxidative stressSteatosisKetosisInflammationFatty acid synthesisMFN2InflammasomeMechanistic target of rapamycinAntioxidantMalondialdehydeGlutathione peroxidaseFatty liverProlactinAcetyl-CoA carboxylaseNEFAMethionineMitochondrionAcetyl-CoA Carboxylase 1Mitochondrial respiratory chainKetone bodiesJanus kinase 2PerilipinLipid metabolismFatty acid synthaseReactive oxygen speciesFatty acidOxidative phosphorylationACACAVery low-density lipoproteinPI3K/AKT/mTOR pathwayActivator (genetics)Cell biologyProtein kinase A
8Publications
5H-index
48Citations
Publications 8
Newest
#1Yuxiang Song (JLU: Jilin University)H-Index: 8
#2Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 12 authors...
ABSTRACT Ketosis is a common metabolic disorder in high-producing dairy cows during the peripartal period. Negative energy balance leads to increased circulating levels of nonesterified fatty acids (NEFA) and β-hydroxybutyrate (BHB), consequently increasing the risk of ketosis. It is well-known that NEFA and BHB can induce lipotoxicity and oxidative stress in bovine tissues/organs including the liver and adipose tissue. Although the mammary gland is one important site for NEFA and BHB metabolism...
1 CitationsSource
#1Jihong Dong (JLU: Jilin University)H-Index: 7
#2Gerd Bobe (Linus Pauling Institute)H-Index: 27
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 10 authors...
ABSTRACT Inflammation is critical in the progression from benign hepatic lipidosis to pathological hepatic steatosis. The objective of this study was to examine the potential role of the outer mitochondrial membrane protein mitofusin 2 (MFN2) in the etiology of hepatic steatosis in dairy cows during early lactation. Using a nested case–control design, we compared blood and liver samples from 10 healthy cows and 10 age-matched cows with moderate fatty liver. Cows with moderate fatty liver had hig...
1 CitationsSource
#1Xin Shu (JLU: Jilin University)H-Index: 5
#2Zhiyuan Fang (JLU: Jilin University)H-Index: 5
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 12 authors...
Ketosis is a metabolic disease of dairy cows often characterized by high concentrations of ketone bodies and fatty acids, but low milk protein and milk production. The Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) and the mechanistic target of rapamycin (mTOR) signaling pathways are central for the regulation of milk protein synthesis. The effect of high levels of fatty acids on these pathways and beta-casein synthesis are unknown in dairy cows with clinical ke...
1 CitationsSource
#1Xudong Sun (JLU: Jilin University)H-Index: 7
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 11 authors...
Aims: Nuclear factor E2-related factor 2 (Nrf2) is a regulator of cellular oxidative stress and is also involved in lipid metabolism in adipocytes. However, it remains unknown whether Nrf2 is the l...
9 CitationsSource
#1Jihong Dong (JLU: Jilin University)H-Index: 7
#2Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 13 authors...
ABSTRACT High blood concentrations of nonesterified fatty acids (NEFA) and altered lipid metabolism are key characteristics of fatty liver in dairy cows. In nonruminants, the mitochondrial membrane protein mitofusin 2 (MFN2) plays important roles in regulating mitochondrial function and intrahepatic lipid metabolism. Whether MFN2 is associated with hepatic lipid metabolism in dairy cows with moderate fatty liver is unknown. Therefore, to investigate changes in MFN2 expression and lipid metabolic...
6 CitationsSource
#1Xudong Sun (JLU: Jilin University)H-Index: 7
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 13 authors...
ABSTRACT Dairy cows with ketosis display excessive lipolysis in adipose tissue. Heat-shock protein B7 (HSPB7), a small heat-shock protein, plays important roles in mediating cytoprotective responses to oxidative stress in rodent adipose tissue. Accordingly, it is assumed that HSPB7 may also play important roles in the antioxidant response in adipose tissue of ketotic cows. Therefore, the aim of this study is to investigate (1) the redox state of adipose tissue in ketotic cows and (2) the role an...
7 CitationsSource
#1Xudong Sun (JLU: Jilin University)H-Index: 7
#2Yazhe Wang (JLU: Jilin University)H-Index: 6
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 11 authors...
ABSTRACT High blood concentrations of nonesterified fatty acids (NEFA) during ketosis represent a source of fatty acids for milk fat synthesis and explain the increase in milk fat content in ketotic cows. Cell death-inducing DFFA-like effector a (CIDEA) is a lipid droplet coat protein with important roles in the regulation of milk fat synthesis and secretion in mice. Whether ketosis alters the expression of CIDEA in mammary gland tissue and the extent to which it may contribute to regulation of ...
10 CitationsSource
#1Hongdou Jia (JLU: Jilin University)H-Index: 7
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 13 authors...
ABSTRACT Fatty liver is a common metabolic disorder in dairy cows during the transition period. Perilipin 5 (PLIN5), a lipid droplet coat protein, plays important roles in the development of hepatic steatosis in mice and humans. Whether PLIN5 plays a role in the development of fatty liver in dairy cows is unknown. An in vivo study consisting of 10 healthy and 10 cows with fatty liver was performed to harvest liver tissue and blood samples. In addition, hepatocytes isolated from calves were infec...
10 CitationsSource