Jiege Huo
Nanjing University of Chinese Medicine
Internal medicineOncologyKEGGChemistryApoptosisDecoctionAutophagyChemotherapy-induced peripheral neuropathyPeripheral neuropathyOxaliplatinCancer researchColorectal cancerViability assayCell growthMedicinePI3K/AKT/mTOR pathwayBiologyImmune systemCell biologyCancer cellPharmacology
15Publications
3H-index
28Citations
Publications 15
Newest
#1Jialin Gu (Nanjing University of Chinese Medicine)H-Index: 1
#2Hong Lu (Soochow University (Suzhou))
Last. Jiege Huo (Nanjing University of Chinese Medicine)H-Index: 3
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BACKGROUND To identify the association between diabetes mellitus (DM) and the risk of chemotherapy-induced peripheral neuropathy (CIPN) through a systematic review and meta-analysis. METHODS An electronic literature search was conducted in PubMed, Embase, Web of Science, the Wanfang database, the VIP Journals database (CQVIP), the China National Knowledge Infrastructure (CNKI) database, and the China Biology Medicine database (Sinomed) between January 2010 and January 2021. Articles were include...
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#1Ziyu Jiang (Nanjing University of Chinese Medicine)H-Index: 1
#1Ziyu Jiang (Nanjing University of Chinese Medicine)H-Index: 1
Last. Jiege Huo (Nanjing University of Chinese Medicine)H-Index: 3
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Microorganisms have been known to coexist in various parts of human body including the gut. The interactions between microbes and the surrounding tissues of the host are critical for fine fettle of the gut. The incidence of such microorganisms tends to vary among specific type of cancer affected individuals. Such microbial communities of specific tumor sites in cancer affected individuals could plausibly be used as prognostic and/or diagnostic markers for tumors associated with that specific sit...
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#1Fengxia QinH-Index: 1
#2Hou-Xi Xu (Nanjing University of Chinese Medicine)H-Index: 3
Last. Jiege HuoH-Index: 3
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Background: Colorectal cancer (CRC) is one of the most common malignant tumors with a poor prognosis. At present, the pathogenesis is not completely clear. Therefore, finding reliable prognostic indicators for CRC is of important clinical significance. In this study, bioinformatics methods were used to screen the prognostic immune-related lncRNAs of CRC, and a prognostic risk scoring model based on immune-related lncRNAs signatures were constructed to provide a basis for prognostic evaluation an...
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#1Guoli Wei (Nanjing University of Chinese Medicine)H-Index: 3
#2Zhancheng Gu (Nanjing University of Chinese Medicine)
Last. Jiege Huo (Nanjing University of Chinese Medicine)H-Index: 3
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Oxaliplatin-induced peripheral neuropathy (OIPN) is a common and dose-limiting toxic effect that markedly limits the use of oxaliplatin and affects the quality of life. Although it is common, the underlying mechanisms of OIPN remain ambiguous. Recent studies have shown that the platinum accumulation in peripheral nervous system, especially in dorsal root ganglion, is a significant mechanism of OIPN. Several specific transporters, including organic cation transporters, high-affinity copper uptake...
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#1Jialin Gu (Nanjing University of Chinese Medicine)H-Index: 1
#2Guoli Wei (Nanjing University of Chinese Medicine)H-Index: 3
Last. Jiege Huo (Nanjing University of Chinese Medicine)H-Index: 3
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Early detection and treatment are critical for preventing catheter allotopia in the totally implantable access ports and whenever possible, the right internal jugular vein should be selected as the first puncture point.
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#1Canhong Hu (Nanjing University of Chinese Medicine)H-Index: 1
#2Shao Xiang (Nanjing University of Chinese Medicine)
Last. Fang Zhijun (Nanjing University of Chinese Medicine)
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Background: Salidroside, an active ingredient of Rhodiola rosea, exhibits antiproliferative effect in gastric cancer (GC) cells. However, the involvement of salidroside in apoptosis and autophagy of GC cells has not been elucidated. Materials and Methods: Cell viability of BGC-823 cells was assessed by CCK-8 assay, and apoptosis was analyzed with terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling assay and flow cytometry. The apoptosis- and autophagy-associated proteins an...
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#1Rong Ding (Nanjing University of Chinese Medicine)H-Index: 2
#2Yue Wang (Nanjing University of Chinese Medicine)
Last. Jiege Huo (Nanjing University of Chinese Medicine)H-Index: 3
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The effects of Danggui Sini decoction on peripheral neuropathy in oxaliplatin-induced peripheral is established. The results indicated that Danggui Sini decoction treatment significantly reduced the current amplitude of dorsal root ganglia cells undergoing agonists stimuli compared to the model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment significantly inhibited the inflammatory response of dorsal root ganglia cells compared to the model-dorsal root ganglia group (P < 0...
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#1Jialin Gu (Nanjing University of Chinese Medicine)H-Index: 1
#2Guoli Wei (Nanjing University of Chinese Medicine)H-Index: 3
Last. Jiege Huo (Nanjing University of Chinese Medicine)H-Index: 3
view all 9 authors...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of anticancer treatment, which may influence its successful completion. The Huang-Qi-Gui-Zhi-Wu-Wu decoction (HQGZWWD) has been widely used to treat CIPN in China although the pharmacological mechanisms involved have not been clarified. Using the network pharmacology approach, this study investigated the potential pathogenesis of CIPN and the therapeutic mechanisms exerted by the HQGZWWD herbal formula in CIPN. The targets...
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#1Jun QianH-Index: 2
#2Yi CaoH-Index: 1
Last. Jiege HuoH-Index: 3
view all 8 authors...
1 CitationsSource
#1Xiaofei Huang (Nanjing University of Chinese Medicine)H-Index: 1
#2Jun Qian (Nanjing University of Chinese Medicine)H-Index: 2
Last. Jiege Huo (Nanjing University of Chinese Medicine)H-Index: 3
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BACKGROUND Curcumol was presented to unleash antitumor effects in a variety of cancers, including gastric cancer. However, the relevance between curcumol and cisplatin resistance in gastric cancer still remains unclear. Therefore, the current research was performed to survey the role of curcumol in cisplatin sensitivity in gastric cancer. METHODS First, BGC-823 and BGC-823/DDP cells were incubated with cisplatin for 48 hr and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT...
1 CitationsSource