Daniel R Frei
Wellington Management Company
Interquartile rangeInternal medicineRandomized controlled trialIntensive care medicineEmergency medicineThiamineIntensive care unitContractureCombination therapyOxygen toxicitySeptic shockResuscitationResponse rate (survey)SepsisOrgan dysfunctionMalignant hyperthermiaHydrocortisoneRapid sequence inductionHypoxia (medical)MEDLINEAnesthesiologyCricoid pressurePulse oximetryOxygen therapyHyperoxiaGold standardFoundation (evidence)Airway managementShock (circulatory)Acute carePopulationAnaesthetic recordAscorbic acidIntensive careSurgical site infectionGrading scaleQuadriceps muscleIn patientIncreased riskPotential impactLarge seriesPractice patternsPerioperativeAnesthesiaFamily medicineClinical trialMedicine
10Publications
3H-index
125Citations
Publications 9
Newest
#1Paul J YoungH-Index: 40
#2Daniel R Frei (Wellington Management Company)H-Index: 3
Nearly all patients receiving treatment in a peri-operative or intensive care setting receive supplemental oxygen therapy. It is biologically plausible that the dose of oxygen used might affect important patient outcomes. Most peri-operative research has focussed on oxygen regimens that target higher than normal blood oxygen levels. Whereas, intensive care research has mostly focussed on conservative oxygen regimens which assiduously avoid exposure to higher than normal blood oxygen levels. Whil...
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#1Ravi Mistry (Wellington Hospital)H-Index: 1
#2Daniel R Frei (Wellington Management Company)H-Index: 3
Last. James Broadbent (Wellington Hospital)H-Index: 1
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We conducted a survey of Australian and New Zealand anaesthetists designed to quantify self-reported use of cricoid pressure (CP) in patients presumed to be at risk of gastric regurgitation, and to...
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#1Daniel R Frei (Alfred Hospital)H-Index: 3
#2Paul J Young (Wellington Hospital)H-Index: 40
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#5Glenn M Eastwood (Austin Hospital)H-Index: 4
Importance It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock. Objective To determine whether the combination of vitamin C, hydrocortisone, and thiamine, compared with hydrocortisone alone, improves the duration of time alive and free of vasopressor administration in patients with septic shock. Design, Setting, and Participants Multicenter, open-label, randomized clinical trial conducted in 10 intens...
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#1Bodil Steen Rasmussen (AAU: Aalborg University)H-Index: 23
#2Daniel R Frei (Wellington Management Company)H-Index: 3
Last. Paul J Young (Wellington Management Company)H-Index: 40
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Purpose of Review Oxygen therapy is administered liberally to give a margin of safety against life-threatening hypoxia; however, excessive supplementary oxygen may increase the risk of serious adverse events with a potential negative impact on both morbidity and mortality. This review focuses on the current evidence and emerging data relating to oxygen therapy in the perioperative setting.
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#1Tomoko Fujii (Monash University)H-Index: 16
#2Andrew A. Udy (Monash University)H-Index: 33
Last. Rinaldo BellomoH-Index: 169
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BACKGROUND: Septic shock is associated with poor outcomes. Vitamin C (ascorbic acid) is a cellular antioxidant and has anti-inflammatory properties. Whether the combination therapy of vitamin C, thiamine and hydrocortisone reduces vasopressor dependency in septic shock is unclear. OBJECTIVES: To describe the protocol and statistical analysis plan of a multicentre, open-label, prospective, phase 2 randomised clinical trial evaluating the effects of vitamin C, thiamine and hydrocortisone when comp...
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#1Daniel R Frei (Wellington Management Company)H-Index: 3
#2Richard Beasley (Wellington Management Company)H-Index: 102
Last. Paul J Young (Wellington Management Company)H-Index: 40
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We conducted a survey of Australian and New Zealand anaesthetists to determine self-reported practice of perioperative oxygen administration and to quantify perceptions regarding the perceived bene...
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Abstract Avoidance and treatment of hypoxaemia is a cornerstone of acute resuscitation and yet the optimal approach to oxygen therapy in the acute care setting is uncertain. The aim of this review is to appraise recent evidence relating to the provision of supplemental oxygen to adult patients with acute illnesses with a focus on the resuscitation phase. Recent findings generally support the notion that exposure to hyperoxaemia is associated with adverse outcomes in acutely ill adults with a ran...
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#1Daniel R Frei (Wellington Management Company)H-Index: 3
#2Kathryn M. Stowell (Massey University)H-Index: 21
Last. Terasa BulgerH-Index: 7
view all 6 authors...
Testing for malignant hyperthermia in New Zealand involves two tests—in vitro contracture testing of excised lateral quadriceps muscle and DNA analysis. In vitro contracture testing is regarded as ...
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