Zhenxing Ren
Guangzhou University of Chinese Medicine
Messenger RNAAdductNeuriteGene silencingElectron transferInternal medicineEndocrinologySNAP25microRNACellHigh-performance liquid chromatographyGene expression profilingChemistryApoptosisChelationSteric effectsRho-associated protein kinaseOxidative stressVascular dementiaAntioxidantGallic acidCrude drugROCK2AntagomirDementiaGallateFerricOncogeneDPPHCell cycleElectrospray ionizationChromatographyReverse transcription polymerase chain reactionCancer researchSynapsin IStrokeFlow cytometryBioinformaticsStereochemistryMedicineMicroarray analysis techniquesTranscription factorBiologyUntranslated regionCell biology
6Publications
5H-index
51Citations
Publications 6
Newest
#1Xin Liu (Guangzhou University of Chinese Medicine)H-Index: 2
#2Ruilin Zhang (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 8 authors...
: Forkhead box P2 (Foxp2) is a transcription factor involved in vocal learning. However, the number of previous studies that have investigated the role of Foxp2 in early vascular dementia (VD) is limited. The aim of the present study was to determine whether microRNA (miR)‑134‑5p/Foxp2 contributes to cognitive impairment in a chronic ischemia‑induced early VD model. miR‑134‑5p was found to be significantly increased in the cortex in a rat VD model. Intracerebroventricular injection of miR‑134‑5p...
4 CitationsSource
#1Wenwen Si (Guangzhou University of Chinese Medicine)H-Index: 4
#2Shanyu Ye (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 11 authors...
: Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been investigated. In the present study, a rat model of middle cerebral artery occlusion (MCAO) was utilized and miRNA array profiling and reverse transcription‑quantitative polymerase chain reaction were p...
14 CitationsSource
#1Zhenxing Ren (Guangzhou University of Chinese Medicine)H-Index: 5
#2Junlong Yu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 9 authors...
Vascular dementia (VD) is the most common form of dementia in the elderly. However, little is understood about the role of microRNAs (miRNAs) involved in cognitive impairment in early VD. Here, VD model induced by chronic cerebral ischemia and FBS-free cell model detecting synapse formation were established to investigate the function of microRNAs in early VD. Microarray analysis and real-time reverse transcription PCR showed that miR-210-5p increased significantly in the hippocampus of rat with...
20 CitationsSource
#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
#2Zhenxing Ren (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 8 authors...
Sanggenons C and D are two Diels-Alder-type adducts from Chinese crude drug Sang-bai-pi. Structurally, both sanggenons construct stereoisomers. In the study, they were comparatively determined using four antioxidant assays, including ferric ion reducing antioxidant power (FRAP) assay, Cu2+-reducing assay, 1,1-diphenyl-2-picryl-hydrazl (DPPH•)-scavenging assay, and 2,2′-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid radical (ABTS•+)-scavenging assay. Their Fe2+-binding reactions were explored...
4 CitationsSource
#1Hong Xie (Guangzhou University of Chinese Medicine)H-Index: 10
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 8 authors...
Tibetan tea (Kangzhuan) is an essential beverage of the Tibetan people. In this study, a lyophilized aqueous extract of Tibetan tea (LATT) was prepared and analyzed by HPLC. The results suggested that there were at least five phenolic components, including gallic acid, and four catechins (i.e., (+)-catechin, (−)-catechin gallate (CG), (−)-epicatechin gallate (ECG), and (−)-epigallocatechin gallate). Gallic acid, the four catechins, and LATT were then comparatively investigated by four antioxidan...
17 CitationsSource
#1Yuqing Liu (GU: Guangzhou University)H-Index: 2
#2Yunjun LiH-Index: 2
Last. Dongfeng Chen (GU: Guangzhou University)H-Index: 22
view all 10 authors...
: Ischemic strokes carry a significant risk of mortality and recurrent vascular events. Recent studies suggest that changes in microRNAs (miRNAs or miRs) may affect the development of the stroke. However, few studies have investigated the role of miRNAs in behavioral disorder in early stroke. In the present study, animal models of middle cerebral artery occlusion (MCAO) are used, as well as a cell model of neurite outgrowth to further investigate the role of miRNAs in targeting synapse-associate...
3 CitationsSource