Olga Bragina
Tomsk Polytechnic University
RadiologyUrologyMolecular imagingAbsorbed doseMolecular biologyAntibodyNanotechnologyChemistryFerroicsMaterials scienceAdverse effectIn vivoIonic bondingDARPinLapatinibLungBiodistributionHistidineTyrosine-kinase inhibitorTrastuzumabUrineKidneyPertuzumabDisseminated cancerElectrode materialSpect imagingNuclear medicineHer2 expressionFirst in humanFdg pet ctOptimal compositionCancer researchTechnetiumBreast cancerHistopathologyDopingMedicineDosimetry
6Publications
4H-index
46Citations
Publications 7
Newest
#1Olga Bragina (RAS: Russian Academy of Sciences)H-Index: 4
Last. Roman Zelchan (RAS: Russian Academy of Sciences)H-Index: 1
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Radionuclide molecular imaging of human epidermal growth factor type 2 (HER2) expression may enable a non-invasive discrimination between HER2-positive and HER2-negative breast cancers for stratification of patients for HER2-targeted treatments. DARPin G3 is a small (molecular weigh 14 kDa) scaffold protein with picomolar affinity to HER2. The aim of this first-in-human study was to evaluate the safety, biodistribution and dosimetry of 99mTc-(HE)3-G3. Methods: Three cohorts of patients with prim...
1 CitationsSource
2 CitationsSource
#1Olga Bragina (RAS: Russian Academy of Sciences)H-Index: 4
#2Emma von Witting (KTH: Royal Institute of Technology)H-Index: 4
Last. Vladimir Tolmachev (Uppsala University)H-Index: 61
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Radionuclide molecular imaging of human epidermal growth factor (HER2) expression may be helpful to stratify breast and gastroesophageal cancer patients for HER2-targeting therapies. ADAPTs (albumin-binding domain derived affinity proteins) are a new type of small (46-59 amino acids) proteins useful as probes for molecular imaging. The aim of this first-in-human study was to evaluate biodistribution, dosimetry, and safety of the HER2-specific 99mTc-ADAPT6. METHODS: Twenty-nine patients with prim...
8 CitationsSource
#1Anzhelika Vorobyeva (Uppsala University)H-Index: 11
#2Alexey A. Schulga (RAS: Russian Academy of Sciences)H-Index: 14
Last. Sergey M. Deyev (Tomsk Polytechnic University)H-Index: 29
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Radionuclide molecular imaging of HER2 expression in disseminated cancer enables stratification of patients for HER2-targeted therapies. DARPin G3, a small (14 kDa) engineered scaffold protein, is a promising probe for imaging of HER2. We hypothesized that position (C- or N-terminus) and composition (hexahistidine or (HE)3) of histidine-containing tags would influence the biodistribution of [99mTc]Tc(CO)3-labeled DARPin G3. To test the hypothesis, G3 variants containing tags at N-terminus (H6-G3...
14 CitationsSource
Last. V. I. ChernovH-Index: 5
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1 CitationsSource
#1Irina V. Belenkaya (RAS: Russian Academy of Sciences)H-Index: 1
#2Olga Bragina (RAS: Russian Academy of Sciences)H-Index: 4
Last. A. P. Nemudry (RAS: Russian Academy of Sciences)H-Index: 8
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Abstract In the present work, we propose to take into account the fact that perovskites with mixed conductivity, as a rule, belong to the ferroics, namely to ferroelastics, which in turn allows us to use models and ideas developed for the related class of ferroics-ferroelectrics. Nanostructuring due to the formation of twins is characteristic for both kinds of materials. This approach allows us to develop a theoretical base for the strategy of doping MIEC perovskites by ferroactive cations, prop...
4 CitationsSource
#1Anzhelika Vorobyeva (Uppsala University)H-Index: 11
#2Olga Bragina (RAS: Russian Academy of Sciences)H-Index: 4
Last. Sergey M. Deyev (Tomsk Polytechnic University)H-Index: 29
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High expression of human epidermal growth factor receptor 2 (HER2) in breast and gastroesophageal carcinomas is a predictive biomarker for treatment using HER2-targeted therapeutics (antibodies trastuzumab and pertuzumab, antibody-drug conjugate trastuzumab DM1, and tyrosine kinase inhibitor lapatinib). Radionuclide molecular imaging of HER2 expression might permit stratification of patients for HER2-targeting therapies. In this study, we evaluated a new HER2-imaging probe based on the designed ...
22 CitationsSource