Andrew E. Massey
National Institutes of Health
EpidemiologyCancerTargeted drug deliveryPhenotypeBiomedical engineeringEthnic groupInternalizationVimentinGene knockdownIntensive care medicineMucinChemistryApoptosisPolyunsaturated fatty acidMesenchymal stem cellCyclin D1In vitroImmunohistochemistryMicrovesiclesHomeobox protein NANOGHealth equityTransmembrane proteinTumor microenvironmentProstateEnzalutamideOrmeloxifeneFatty acid metabolismCombination therapyVinblastinePaclitaxelSmoking cessationSOX2Selective estrogen receptor modulatorCurcuminPancaPancreasMetastasisDiseaseCytokine stormDrug deliveryPLGAProstate cancerPancreatic cancerGemcitabineMMP2PIEZO1DocetaxelExosomeMargaric AcidAndrogen Receptor Splice Variant 7Membrane bendingCell cycleSaturated fatty acidCellular localizationTissue sectionsCancer treatmentNovel techniqueFood scienceMechanosensitive channelsCancer researchRisk factorFatty acidCancer stem cellCell growthMedicineEpithelial–mesenchymal transitionCell cultureAdhesionTubulinBiologyPandemicCell biologyCancer cellPharmacology
14Publications
5H-index
138Citations
Publications 14
Newest
#1Andrew E. Massey (NIH: National Institutes of Health)H-Index: 5
#2Shabnam MalikH-Index: 8
Last. Bilal B. Hafeez (University of Texas at Austin)H-Index: 2
view all 10 authors...
Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implication...
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#1Vivek K. KashyapH-Index: 8
#2Anupam Dhasmana (University of Texas at Austin)H-Index: 7
Last. Subhash C. Chauhan (The University of Texas Rio Grande Valley)H-Index: 5
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The coronavirus disease 2019 (COVID-19) pandemic, an infection caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), has led to more than 771,000 deaths worldwide. Tobacco smoking is a major known risk factor for severe illness and even death from many respiratory infections. The effects of smoking on COVID-19 are currently controversial. Here, we provide an overview of the current knowledge on the effects of smoking on the clinical manifestations, disease progression, inflam...
7 CitationsSource
#1Andrew E. Massey (University of Texas at Austin)H-Index: 5
#2Kyle Doxtater (University of Texas at Austin)H-Index: 3
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 49
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Abstract Background Pancreatic cancer is one of the most lethal cancers in the United States. This is partly due to the difficulty in early detection of this disease as well as poor therapeutic responses to currently available regimens. Our previous reports suggest that mucin 13 (MUC13, a transmembrane mucin common to gastrointestinal cells) is aberrantly expressed in this disease state, and has been implicated with a worsened prognosis and an enhanced metastatic potential in PanCa. However, the...
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#1Andrew E. Massey (University of Texas at Austin)H-Index: 5
#1Andrew E. Massey (University of Texas at Austin)
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 5
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#1Andrew E. Massey (UT: University of Tennessee)H-Index: 5
#2Mohammed Sikander (UT: University of Tennessee)H-Index: 7
Last. Subhash C. Chauhan (UT: University of Tennessee)H-Index: 49
view all 13 authors...
Abstract Pancreatic cancer (PanCa) is a major cause of cancer-related death due to limited therapeutic options. As pancreatic tumors are highly desmoplastic, they prevent appropriate uptake of therapeutic payloads. Thus, our objective is to develop a next-generation nanoparticle system for treating PanCa. We generated a multi-layered Pluronic F127 and polyvinyl alcohol stabilized and poly-L-lysine coated paclitaxel loaded poly(lactic-co-glycolic acid) nanoparticle formulation (PPNPs). This formu...
4 CitationsSource
#1Mohammed SikanderH-Index: 7
#2Shabnam MalikH-Index: 8
Last. Meena Jaggi (UT: University of Tennessee)H-Index: 36
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Background: Cervical cancer (CxC) is a leading cause of mortality and morbidity among women worldwide. Current chemotherapeutic agents for CxC have shown systemic toxicity in CxC patients. Ormeloxifene (ORM) is a non-toxic and non-steroidal drug with well-defined pharmacokinetic and pharmacodynamic properties in humans. Studies have shown its anti-cancer potential in various pre-clinical mouse models. Here, we have synthesized and characterized a novel analogue of ormeloxifene, Bromo-ormeloxifen...
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#1Sheema Khan (UTHSC: University of Tennessee Health Science Center)H-Index: 23
#2Saini Setua (UTHSC: University of Tennessee Health Science Center)H-Index: 7
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 14 authors...
Abstract Pancreatic cancer is a complex disease accounting for fibrotic tumors and an aggressive phenotype. Gemcitabine (GEM) is used as a standard therapy, which develops chemoresistance leading to poor patient outcome. We have recently developed a superparamagnetic iron oxide nanoparticle (SPION) formulation of curcumin (SP-CUR), which is a nontoxic, bioactive anti-inflammatory/anti-cancer agent for its enhanced delivery in tumors. In this study, we demonstrate that SP-CUR effectively delivers...
24 CitationsSource
#1Luis O. Romero (UTHSC: University of Tennessee Health Science Center)H-Index: 4
#2Andrew E. Massey (UTHSC: University of Tennessee Health Science Center)H-Index: 5
Last. Valeria Vásquez (UTHSC: University of Tennessee Health Science Center)H-Index: 14
view all 7 authors...
Mechanosensitive ion channels rely on membrane composition to transduce physical stimuli into electrical signals. The Piezo1 channel mediates mechanoelectrical transduction and regulates crucial physiological processes, including vascular architecture and remodeling, cell migration, and erythrocyte volume. The identity of the membrane components that modulate Piezo1 function remain largely unknown. Using lipid profiling analyses, we here identify dietary fatty acids that tune Piezo1 mechanical r...
57 CitationsSource
#1Luis O. RomeroH-Index: 4
Last. Valeria VásquezH-Index: 14
view all 7 authors...
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#1Bilal Bin Hafeez (UTHSC: University of Tennessee Health Science Center)H-Index: 29
#2Andrew E. Massey (UTHSC: University of Tennessee Health Science Center)H-Index: 5
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 10 authors...
Pancreatic cancer (PanCa) is one of the leading causes of cancer-related mortality in the United States due to very limited therapeutic options. Thus, there is an urgent need to develop novel therapeutic strategies for the management of this disease. Paclitaxel (PTX), a natural product derived from the Pacific Yew tree, is an agent typically used in combination therapy for PanCa. Currently, PTX nanoparticles (Abraxane®) along with gemcitabine are in use for the treatment of advanced PanCa. Herei...
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