Diogo A. Mendonça
Instituto de Medicina Molecular
GlycoproteinCytotoxicityConjugated systemHeptad repeatFusion proteinBiophysicsCellVirologyChemistryLipophilicityIn vitroIn vivoTryptophanSnake venomMeasles virusBlood–brain barrierPeptideSelf-assembling peptideAntiviral drugResidue (chemistry)CrotalicidinEntry into hostProtein stabilityModern medicineAntitumor activityProtein structureAntimicrobialDrug discoveryProtein primary structurePharmacology
4Publications
2H-index
13Citations
Publications 4
Newest
#1Diogo A. Mendonça (IMM: Instituto de Medicina Molecular)H-Index: 2
#2Mariët Bakker (Avans University of Applied Sciences)
Last. Toni Todorovski (UPF: Pompeu Fabra University)H-Index: 7
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Passing through the blood-brain barrier (BBB) to treat neurological conditions is one of the main hurdles in modern medicine. Many drugs with promising in vitro profiles become ineffective in vivo due to BBB restrictive permeability. In particular, this includes drugs such as antiviral porphyrins, with the ability to fight brain-resident viruses causing diseases such as HIV-associated neurocognitive disorders (HAND). In the last two decades, BBB shuttles, particularly peptide-based ones, have sh...
Source
#1Clara Pérez-Peinado (Barcelona Biomedical Research Park)H-Index: 6
#2Susana A. Dias (IMM: Instituto de Medicina Molecular)H-Index: 6
Last. David Andreu (Barcelona Biomedical Research Park)H-Index: 70
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: Ctn[15-34], a downsized version of the snake venom cathelicidin-like peptide crotalicidin (Ctn), shows an unusually high lifespan (t1/2 , approximately 12 h) in human serum, which significantly adds to its promise as an antimicrobial and antitumor agent. Herein we investigate the role of Ctn[15-34] structure on serum survival. Using a set of analogs, we show that C-terminal amidation, as well as the specific layout of the Ctn[15-34] sequence-a helical N-terminal domain followed by a hydrophobi...
6 CitationsSource
#1Diogo A. Mendonça (IMM: Instituto de Medicina Molecular)H-Index: 2
#2Tiago N. Figueira (IMM: Instituto de Medicina Molecular)H-Index: 7
Last. Ana Salomé Veiga (IMM: Instituto de Medicina Molecular)H-Index: 19
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The resurgence of several infectious diseases, like measles, has driven the search for new chemotherapeutics to prevent and treat viral infections. Self-assembling antiviral peptides are a promising class of entry inhibitors capable of meeting this need. Fusion inhibitory peptides derived from the heptad repeat of the C-terminal (HRC) of the measles fusion protein, dimerized and conjugated with lipophilic groups, were found to be efficacious against measles virus. The structures of the self-asse...
1 CitationsSource
#1Tiago N. Figueira (IMM: Instituto de Medicina Molecular)H-Index: 7
#2Diogo A. Mendonça (IMM: Instituto de Medicina Molecular)H-Index: 2
Last. Ana Salomé Veiga (IMM: Instituto de Medicina Molecular)H-Index: 19
view all 8 authors...
Measles remains one of the leading causes of child mortality worldwide and is re-emerging in some countries due to poor vaccine coverage, concomitant with importation of measles virus (MV) from endemic areas. The lack of specific chemotherapy contributes to negative outcomes, especially in infants or immunodeficient individuals. Fusion inhibitor peptides derived from the MV Fusion protein C-terminal Heptad Repeat (HRC) targeting MV envelope fusion glycoproteins block infection at the stage of en...
7 CitationsSource