Lijuan Yu
Guangzhou University of Chinese Medicine
Regenerative medicinePhosphorylationmicroRNACellReporter geneChemistryProtein kinase CMesenchymal stem cellIn vitroIn vivoSmall interfering RNAWestern blotROCK2Homing (hematopoietic)Bone marrowWNT5AWound healingCartilageMTT assayStem cellPopulationTransplantationChondrogenesisCa2+/calmodulin-dependent protein kinaseViability assayTransfectionSignal transductionMyosin light-chain kinaseBiologyHedgehog signaling pathwayCell biology
Publications 4
#1Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
Last. Gang Li (CUHK: The Chinese University of Hong Kong)H-Index: 84
view all 12 authors...
Abstract Mesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. MSCs could be recruited by inflammatory stimulation, then home to the injury tissues. However, its capacity of homing is extremely limited. Thus, it has become extremely necessary to develop an agent or a method, which can be us...
2 CitationsSource
#1Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Wang-Yang Li (Hunan University)H-Index: 1
Last. Wang Bin (GU: Guangzhou University)H-Index: 4
view all 14 authors...
ABSTRACT MSC transplantation has been explored as a new clinical approach to stem cell-based therapies for bone diseases in regenerative medicine due to their osteogenic capability. However, only a small population of implanted MSC could successfully reach the injured areas. Therefore, enhancing MSC migration could be a beneficial strategy to improve the therapeutic potential of cell transplantation. Catharmus tinctorius volatile oil (CTVO) was found to facilitate MSC migration. Further explorat...
2 CitationsSource
#1Liuchao Hu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Yiwen Luo (Guangzhou University of Chinese Medicine)H-Index: 5
view all 13 authors...
: Bone fractures are very common, and above 5% of the fractures are impaired, leading to nonunions and severe disablilities. The traditional Chinese medicine Bushen Huoxue decoction (BHD) has been used to treat fracture in China. Our previous report has found that BHD promotes migration of rat mesenchymal stem cells (rMSCs) by activating Wnt5a signaling pathway. However, whether and how miRNAs are involved in modulating rMSCs migration induced by BHD has not been explored. In the present study, ...
2 CitationsSource
#1Wei Shen (GU: Guangzhou University)H-Index: 2
#2Hui Luo (GU: Guangzhou University)H-Index: 1
Last. Yiwen Luo (GU: Guangzhou University)H-Index: 5
view all 10 authors...
Background Bushen Huoxue decoction (BHD) has a significant effect on fracture rehabilitation, yet its underlying mechanism is still unknown. The purpose of this study was to explore whether BHD promotes bone marrow mesenchymal stem cell (BMSC) migration through the Wnt5a signalling pathway.
7 CitationsSource