Rui-Yi Yang
Guangzhou University of Chinese Medicine
Insulin receptorAdipogenesisEndocrinologyLipogenesisWhite adipose tissueCarbohydrate metabolismAdipose tissueChemistryAdipokineIRS1AdipocyteInsulin resistanceFatty liverCD36Type 2 Diabetes MellitusLipid metabolismDiabetes mellitusApolipoprotein BACACAOvariectomized rat
3Publications
1H-index
9Citations
Publications 3
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#1Zhuo-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 2
#2Jia-Wen Huang (Guangzhou University of Chinese Medicine)
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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Abstract Background We had reported that cajanolactone A (CLA) from Cajanus cajan dose-dependently inhibited ovariectomy-induced obesity and liver steatosis in mice, showing potential to prevent postmenopausal obesity and fatty liver. In this study, the role of CLA in the regulation of energy and lipid homeostasis was investigated. Methods Ovariectomized mice treated with CLA or vehicle for 12 weeks were performed a 48 h monitoring for energy metabolism and food uptake. After that, hypothalami, ...
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#1Zhuo-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 2
#2Zhi-Wen Liu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
view all 8 authors...
ABSTRACT BACKGROUND : Visceral obesity and fatty liver are prevalent in postmenopausal women. The stilbene-rich extract of Cajanus cajan (L.) Millsp. has been reported to prevent ovariectomy-induced and diet-induced weight gain in animal models, and stilbenoids from C. cajan are thought to have the potential to prevent postmenopausal obesity and fatty liver. PURPOSE : Cajanolactone A (CLA) is the main stilbenoid from C. cajan with osteoblastogenic promoting activity. This study investigated the ...
1 CitationsSource
#1Rui-Yi Yang (Guangzhou University of Chinese Medicine)H-Index: 1
#2Lu Wang (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
view all 8 authors...
: The present study investigated the effects of cajanonic acid A (CAA), extracted from the leaves of Cajanus cajan (L.) Millsp with a purity of 98.22%, on the regulatory mechanisms of glucose and lipid metabolism. HepG2 cells transfected with a protein‑tyrosine phosphatase 1B (PTP1B) overexpression plasmid were established. The cells, induced with insulin resistance by dexamethasone (Dex) treatment, together with type 2 diabetes mellitus (T2DM) model rats and ob/ob mice, were used in the present...
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