Sumeet S. Chauhan
University of Texas at Austin
CancerTargeted drug deliveryChemistryApoptosisIn vitroPaclitaxelDrug deliveryDrugPancreatic cancerGemcitabinePectinTannic acidCancer researchBreast cancerBiochemistryCell growthMedicineCell cultureCancer cell
2Publications
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#1Sumeet S. Chauhan (University of Texas at Austin)H-Index: 2
#2Advait B. Shetty (UTHSC: University of Tennessee Health Science Center)H-Index: 3
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 3
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Pancreatic cancer (PanCa) is a lethal disease. Conventional chemotherapies for PanCa offer severe systemic toxicities. Thus, the development of a successful nanomedicine-based therapeutic regimen with augmented therapeutic efficacy is highly sought. Naturally occurring pectin and modified pectin-based drug delivery systems exhibit remarkable self-targeting ability via galactose residues to various cancer cells. Herein, we developed and used an innovative approach of highly stable nanocomplexes b...
5 CitationsSource
#1Pallabita Chowdhury (UT: University of Tennessee)H-Index: 1
#2Sumeet S. ChauhanH-Index: 2
Last. Murali M. Yallapu (UT: University of Tennessee)H-Index: 34
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Objectives: Paclitaxel (Ptxl) is currently the most common first-line therapeutic option for breast cancer (BrCa). However, adverse side effects and problems associated with chemo-resistance, limits its use in clinical settings. Nanoparticle mediated delivery can improve Ptxl delivery and its activity at the tumor site, and considered to be an attractive strategy for BrCa therapy. Therefore, we aim to generate a novel Ptx medical nanoparticle formulation (PMNPs) using a polyphenol as a carrier, ...
4 CitationsSource