Marta Casal Moura
Mayo Clinic
MutantMolecular biologyAntibodyDermatologyRetrospective cohort studyChemistryEpitopeProteinase 3Anti-neutrophil cytoplasmic antibodyVasculitisAsthmaAntigenicityEosinophilicAutoimmunityRituximabPericarditisGranulomatosis with polyangiitisMonoclonal antibodyMedicineGastroenterology
21Publications
3H-index
34Citations
Publications 20
Newest
#1Gwen Thompson (Essentia Health)H-Index: 4
#1Gwen E. Thompson (Essentia Health)
Last. Ulrich Specks (Mayo Clinic)H-Index: 63
view all 10 authors...
Abstract Background Pleural and pericardial involvement are well recognized in eosinophilic granulomatosis with polyangiitis (EGPA) but considered rare manifestations of the other ANCA-associated vasculitides (AAV). Research Question What are the frequency and clinical characteristics of pleuritis and pericarditis in AAV? Study Design and Methods Using an institutional database of 1,830 AAV patients, clinical notes and diagnosis codes were analyzed for key words related to pleuritis and pericard...
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#1Ulrich Specks (Mayo Clinic)H-Index: 63
#2Lynn A. Fussner (OSU: Ohio State University)H-Index: 1
Last. Fernando C. Fervenza (Mayo Clinic)H-Index: 63
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Advances in the diagnosis and treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis have led to continued improvement in survival and prognosis over the course of the last 4 decades. Nevertheless, the most acute and severe disease manifestations, including severe kidney disease and alveolar hemorrhage, continue to be associated with increased early mortality from disease activity or treatment complications as well as risk for the development of end-stage kidney disease (...
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#1Aishwarya Ravindran (Mayo Clinic)H-Index: 10
#2Marta Casal Moura (Mayo Clinic)H-Index: 3
Last. Sanjeev Sethi (Mayo Clinic)H-Index: 54
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BACKGROUND In patients with secondary (autoimmune) membranous nephropathy, two novel proteins, Exostosin 1 and Exostosin 2 (EXT1/EXT2), are potential disease antigens, biomarkers, or both. In this study, we validate the EXT1/EXT2 findings in a large cohort of membranous lupus nephritis. METHODS We conducted a retrospective cohort study of patients with membranous lupus nephritis, and performed immunohistochemistry studies on the kidney biopsy specimens against EXT1 and EXT2. Clinicopathologic fe...
4 CitationsSource
#1Marta Casal Moura (Mayo Clinic)H-Index: 3
#2Misbah Baqir (Mayo Clinic)H-Index: 8
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#1Alvise Berti (University of Trento)H-Index: 15
#2Marta Casal Moura (Mayo Clinic)H-Index: 3
Last. Kenneth J. Warrington (Mayo Clinic)H-Index: 40
view all 7 authors...
1 CitationsSource
#1Marta Casal Moura (Mayo Clinic)H-Index: 3
#2Maria V. Irazabal (Mayo Clinic)H-Index: 19
Last. Fernando C. Fervenza (Mayo Clinic)H-Index: 63
view all 17 authors...
BACKGROUND Treatment of patients with ANCA-associated vasculitis (AAV) and severe renal involvement is not established. We describe outcomes in response to rituximab (RTX) versus cyclophosphamide (CYC) and plasma exchange (PLEX). METHODS A retrospective cohort study of MPO- or PR3-ANCA-positive patients with AAV (MPA and GPA) and severe kidney disease (eGFR <30 ml/min per 1.73 m2). Remission, relapse, ESKD and death after remission-induction with CYC or RTX, with or without the use of PLEX, were...
5 CitationsSource
#1Alvise Berti (University of Trento)H-Index: 15
#2Divi Cornec (French Institute of Health and Medical Research)H-Index: 29
Last. Karina A. Keogh (Mayo Clinic)H-Index: 22
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Abstract Background The long-term clinical course of asthma in patients with Eosinophilic Granulomatosis with Polyangiitis (EGPA) remains unclear. We aimed to characterize long-term asthma in EGPA and to identify baseline predictors of long-term asthma severity. Methods Retrospective cohort study of patients who fulfilled standardized criteria for EGPA that were followed in a single referral center between 1990-2017. Baseline and 3 (±1) years of follow-up clinical, laboratory and pulmonary funct...
5 CitationsSource
#1Marta Casal Moura (Mayo Clinic)H-Index: 3
#2Ria Gripaldo (Emory University)
Last. Jay H. Ryu (Mayo Clinic)H-Index: 80
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Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder that has been recognized to involve virtually any organ in the body and typically manifests mass-like lesions (tumefactive). Although initial reports of this disease (autoimmune pancreatitis [AIP]) were described in the Japanese population, it has since been reported worldwide. It is most commonly seen in adults of middle age or older, more often men than women. The pathogenesis of IgG4-RD is largely unknown, bu...
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#1Marta Casal Moura (Mayo Clinic)H-Index: 3
#2Alvise Berti (Mayo Clinic)H-Index: 15
Last. Misbah Baqir (Mayo Clinic)H-Index: 8
view all 6 authors...
Objectives Rituximab (RTX) treatment is used for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis, but its benefits in eosinophilic granulomatosis with polyangiitis (EGPA) are unclear. Our aim was to characterize asthma control and glucocorticoid (GC) sparing after RTX treatment.
2 CitationsSource
#1Yuan Ping Pang (Mayo Clinic)H-Index: 45
#2Marta Casal Moura (Mayo Clinic)H-Index: 3
Last. Ulrich Specks (Mayo Clinic)H-Index: 63
view all 10 authors...
Mutants of a catalytically inactive variant of Proteinase 3 (PR3)—iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103—offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in granulomatosis with polyangiitis (GPA) and whether such interactions can be interrupted. Here we report that iHm5-Val103, a triple mutant of iPR3-Val103, bound a monoclonal antibody (moANCA518) from a GPA patient on an epitope remote from the mutation s...
1 CitationsSource
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