Shenxin Xuan
Guangzhou University of Chinese Medicine
TriterpenoidPharmacokineticsCircular dichroismBlood lipidsAbsorption (skin)High-performance liquid chromatographyChemistryTraditional Chinese medicineHypotaurineInflammationOral administrationCortex (anatomy)Metabolic disorderHyperlipidemiaGlyoxylate and dicarboxylate metabolismMesalazineTaurineAconitum carmichaeliiIlex rotundaUlcerative colitisIngredientShikimic acidPedunculosideChaetomium sp.Rotundic acidEndophytic fungusNatural compoundChemical diversityWeight changeKetone bodiesChromatographyAntibioticsGut floraFatty acidMetabolismNuclear magnetic resonance spectroscopySelected reaction monitoringStereochemistryMedicinePharmacology
5Publications
3H-index
14Citations
Publications 5
Newest
Abstract null null Two undescribed shikimic acid derivatives named shikimerans B and C (1 and 2), one new natural compound shikimeran D (3), as well as five known compounds 4−8 were obtained from the EtOAc extract of the endophytic fungus Chaetomium sp. FZ-4. Their structures were determined by the NMR spectroscopy and HRESIMS examination, while the absolute configurations of compounds 1−3 were clarified based on the electronic circular dichroism (ECD) experiment. These new compounds enriched th...
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#1Shiqin Jiang (Guangzhou University of Chinese Medicine)
#2Xiuting Shen (Guangzhou University of Chinese Medicine)
Last. Jing Jin (SYSU: Sun Yat-sen University)H-Index: 13
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Abstract Background : Croton crassifolius Geisel (CCG, also known as Ji-Gu-Xiang in Traditional Chinese Medicine), is traditionally prescribed for the therapy of rheumatic arthritis and gastrointestinal ulcer. However, the effect of CCG on ulcerative colitis (UC) has not been investigated. Purpose : To explore the therapeutic potential and underlying mechanism of CCG extract against UC by colonic and serum metabolomics. Methods : In order to standardize the CCG extract, UPLC-QTOF-MS was used for...
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#1Bao Yang (Guangzhou University of Chinese Medicine)H-Index: 7
#2Shenxin Xuan (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
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ETHNOPHARMACOLOGICAL RELEVANCE: Ilicis Rotundae Cortex (IRC), a Chinese crude drug, has been widely utilized in Guangdong and Guangxi provinces of China to treat or prevent cardiovascular diseases. AIM OF STUDY: This investigation aims to study the lipid-lowering effect of IRC, as well as the regulating effect on the endogenous metabolites in hyperlipidemia rats. MATERIALS AND METHODS: High-fat diet induced hyperlipidemia rats were administrated with different doses of IRC extract (0.5, 1.0 and ...
7 CitationsSource
#1Bao Yang (Guangzhou University of Chinese Medicine)H-Index: 7
#2Hui Li (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
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Rotundic acid and pedunculoside are the most abundant constituents in Ilicis Rotundae Cortex, and possess lipid-lowering activity. In this study, we evaluated the pharmacokinetic interactions of rotundic acid with pedunculoside and other ingredients from Ilicis Rotundae Cortex with rotundic acid and pedunculoside, and preliminarily investigated the effects of gut microbiota on their pharmacokinetics using a pseudo-germ-free rat model. After a single oral administration of each monomer, a monomer...
3 CitationsSource
#1Bao Yang (Guangzhou University of Chinese Medicine)H-Index: 7
#2Hui Li (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
view all 8 authors...
Abstract Triterpenoids, the major bioactive ingredients of Ilicis Rotundae Cortex, contributes a significant cardiovascular protection activity. Although many studies about the total saponins have been reported, the absorption triterpenoids and pharmacokinetic behaviors were unclear. Thus, the present study aims to comprehensive elucidate the absorption triterpenoids and their pharmacokinetics in rats after oral administration the crude extract using UPLC/Q-TOF-MS/MS. A total of forty-two triter...
6 CitationsSource