Bofeng Su
First Affiliated Hospital of Wenzhou Medical University
CCL2Tumor necrosis factor alphaChemistryWestern blotNephritisInflammasomeNF-?BImmune complexCytokineLupus nephritisKidneyIcariinCancer researchTransfectionInterleukinPharmacologyKlotho
2Publications
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Publications 2
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#1Hong Ye (Fujian Medical University)H-Index: 2
#2Bofeng Su (First Affiliated Hospital of Wenzhou Medical University)H-Index: 2
Last. Huidi Zhang (First Affiliated Hospital of Wenzhou Medical University)H-Index: 1
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Abstract Klotho is considered to have renal protective effect by prohibiting the activation of the nuclear factor (NF)-κB pathway, while the role of microRNA-199a (miR-199a)/Klotho in lupus nephritis (LN) is still unknown. A single dose of pristane (0.5 ml) was intraperitoneally injected into 8 weeks-old female mice to establish the LN model. MiR-199a mimic or miR-199a inhibitor, Klotho plasmid or Klotho siRNA, and miR-199a inhibitor plus si-Klotho were transfected into lipopolysaccharides (LPS)...
9 CitationsSource
#1Bofeng Su (First Affiliated Hospital of Wenzhou Medical University)H-Index: 2
#2Hong Ye (Fujian Medical University)H-Index: 2
Last. Linlin Li (Fujian Medical University)H-Index: 2
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Abstract Aims Lupus nephritis (LN) is a kidney inflammatory disease caused by systemic lupus erythematosus (SLE). Both NF-κB activation and NLRP3 inflammasome activation are implicated in LN pathogenesis, suggesting they are potential targets for LN treatment. Icariin, which is isolated from Chinese medicine Horny Goat Weed (Ying Yang Huo), has been shown to have anti-inflammation activity, and inhibit activations of both NF-κB and NLRP3 inflammasome. In present study, the effects of icariin on ...
17 CitationsSource