Lauren E. Colbert
University of Texas MD Anderson Cancer Center
CancerInternal medicineRadiologySurgeryMicrobiomeOncologyChemotherapyCervical cancerChemoradiotherapyPancreatic cancerAdenocarcinomaToxicityNuclear medicineIn patientCancer researchRadiation therapyMedicineBiomarker (medicine)BiologyImmune systemGastroenterology
Publications 116
Purpose/Objective(s) null Radiation therapy is curative for treating cervical, vaginal, and anal cancers, but can lead to gut toxicities that reduce quality of life in recovering patients. Previously, higher gut microbiome diversity was shown to be positively correlated with less severe acute gastrointestinal (GI) toxicities per patient-reported assessments of bowel function. The goal of this study was to explore effects of gut microbiome diversity and composition on late GI toxicities. We hypot...
#1J.K. Bronk (University of Texas MD Anderson Cancer Center)
#2Xiaogang Wu (University of Texas MD Anderson Cancer Center)H-Index: 2
Last. Lois M. Ramondetta (University of Texas MD Anderson Cancer Center)H-Index: 33
view all 20 authors...
PURPOSE/OBJECTIVE(S) Clinically relevant genetic predictors of radiation response for cervical cancer are understudied due to the morbidity of repeat invasive biopsies required to obtain genetic material. We have developed a novel noninvasive cervical swab technique to collect tumor DNA with adequate throughput to perform whole exome sequencing (WES) at serial timepoints over the course of chemoradiation therapy (CRT). We hypothesize that characterization of dynamic changes in the mutational lan...
#1Olsi Gjyshi (University of Texas MD Anderson Cancer Center)H-Index: 9
#2Adam Grippin (UF: University of Florida)H-Index: 12
Last. Travis Solley (University of Texas MD Anderson Cancer Center)H-Index: 9
view all 13 authors...
Purpose/objective(s) null The role of the immune system in mediating the cytotoxic effects of chemoradiotherapy, remains incompletely understood. The integration of immunotherapies into treatment will require insight into features and timing of immune microenvironment associated with treatment response. Here, we investigate the role of circulating and tumor-associated neutrophils (TANs) as potential agents and biomarkers for disease-related outcomes in LACC. null Materials/methods null Hematolog...
#5Anil K. Sood (University of Texas MD Anderson Cancer Center)H-Index: 135
PURPOSE/OBJECTIVE(S) Pelvic insufficiency fractures and decreased bone mineral density (BMD) can occur in women treated with radiotherapy (RT) for gynecologic cancers. The purpose of this study was to compare the magnitude of BMD changes inside and outside of the radiation field in patients treated with radiation +/- chemotherapy for cervical cancer. MATERIALS/METHODS In an IRB-approved prospective study, women (N = 78) with cervical cancer were assessed with serial tomographic scans and dual-en...
#1K.L. Corrigan (University of Texas MD Anderson Cancer Center)H-Index: 1
#2Alison Yoder (University of Texas MD Anderson Cancer Center)H-Index: 3
Last. Ann H. Klopp (University of Texas MD Anderson Cancer Center)H-Index: 33
view all 9 authors...
Purpose/Objective(s) null Radiation therapy (RT) has been shown to prolong survival for patients with select oligometastatic cancers. Limited long-term follow-up data exist to determine if the prolonged survival correlates with cure versus a delayed relapse. To investigate this, we evaluated the clinical and disease characteristics of long-term survivors treated with definitive RT for oligometastatic gynecological cancer at our institution. null null null Materials/Methods null We performed a la...
#1Daniel Lin (University of Texas MD Anderson Cancer Center)H-Index: 6
#2Molly B. El Alam (University of Texas MD Anderson Cancer Center)H-Index: 3
Last. Nicholas D. Nguyen (University of Texas MD Anderson Cancer Center)H-Index: 3
view all 23 authors...
Abstract null IMPORTANCE null Patients with localized squamous cell carcinoma of the anus (SCCA) who experience treatment toxicity or recurrences have few therapeutic options. null Investigation into the microbiome’s influence on treatment toxicity or its potential use as a predictive biomarker in this rare disease could improve these patients’ outcomes. null OBJECTIVE null To longitudinally characterize the SCCA tumor microbiome and assess its association with treatment-related toxicities. null...
#2Doreen Ramogola-Masire (UB: University of Botswana)H-Index: 14
#8Melissa Paola Mezzari (BCM: Baylor College of Medicine)H-Index: 13
Objectives: null We assessed geographic differences by characterizing the cervical 16S rDNA microbiome of women with locally advanced squamous cell carcinoma of the cervix being treated in Botswana and in the United States. null null null Methods: null We characterized the 16S rDNA cervical microbiome of 13 US women (0 HIV-infected, 13 HIV-uninfected) and 11 Botswana women (8 HIV-infected, 3 HIV-uninfected). Shannon diversity index was used to evaluate alpha (intra-sample) diversity, while the U...
#1Stephen R. Grant (University of Texas MD Anderson Cancer Center)H-Index: 9
#2Benjamin Smith (University of Texas MD Anderson Cancer Center)H-Index: 113
Last. Aileen B. Chen (University of Texas MD Anderson Cancer Center)H-Index: 23
view all 7 authors...
BACKGROUND There exists wide practice variability in palliative treatment schedules for bone metastases. In an effort to reduce variation and promote high-quality, cost-conscious care, the National Quality Forum (NQF) endorsed measure 1822 in 2012. This measure recommends the use of 30 Gy in 10 fractions, 24 Gy in 6 fractions, 20 Gy in 5 fractions, or 8 Gy in a single fraction for palliative radiation for bone metastases. We report on longitudinal compliance with this measure. METHODS Using the ...
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