Peter Paine
University of Manchester
Internal medicineSurgeryNeuroscienceIntensive care medicinePediatricsStimulationReferralBile acid malabsorptionAutonomic nervous systemIrritable bowel syndromeHyperalgesiaVisceral painAbdominal painNeurogastroenterologyGastrointestinal dysmotilityIn patientIntestinal failureAnesthesiaIncidence (epidemiology)AnxietyMedicineParenteral nutritionGastroenterology
Publications 69
#1Dipesh H. Vasant (University of Manchester)H-Index: 10
#2Peter Paine (University of Salford)H-Index: 15
Last. Alexander C. Ford (St James's University Hospital)H-Index: 86
view all 14 authors...
Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders seen by clinicians in both primary and secondary care. Since publication of the last British Society of Gastroenterology (BSG) guideline in 2007, substantial advances have been made in understanding its complex pathophysiology, resulting in its re-classification as a disorder of gut-brain interaction, rather than a functional gastrointestinal disorder. Moreover, there has been a considerable amount of new ev...
#1Hani Essa (University of Salford)H-Index: 1
#2Shaheen Hamdy (University of Manchester)H-Index: 52
Last. Peter Paine (University of Manchester)H-Index: 15
view all 8 authors...
Background Contention surrounds hydrogen and methane breath tests as putative measures of small intestinal bacterial overgrowth. We aimed to explore the clinical characteristics associated with positive and negative results to help clarify their role. Methods 525 glucose hydrogen/methane breath tests completed over 3 years were analyzed to look for positively and negatively associated predictive factors. Characteristics such as height and weight and underlying medical conditions, medications, an...
#1Peter Paine (Salford Royal NHS Foundation Trust)H-Index: 15
#2Marie McMahon (Salford Royal NHS Foundation Trust)H-Index: 2
Last. Simon Lal (Salford Royal NHS Foundation Trust)H-Index: 33
view all 5 authors...
The decision to commence jejunal feeding in patients with structural abnormalities, which prevent oral or intragastric feeding, is usually straightforward. However, decisions surrounding the need for jejunal feeding can be more complex in individuals with no clear structural abnormality, but rather with foregut symptoms and pain-predominant presentations, suggesting a functional origin. This appears to be an increasing issue in polysymptomatic patients with multi-system involvement. We review th...
1 CitationsSource
#1J.M.D. NightingaleH-Index: 21
#2Peter Paine (University of Salford)H-Index: 15
Last. Simon Lal (University of Salford)H-Index: 33
view all 6 authors...
Adult patients with severe chronic small intestinal dysmotility are not uncommon and can be difficult to manage. This guideline gives an outline of how to make the diagnosis. It discusses factors which contribute to or cause a picture of severe chronic intestinal dysmotility (eg, obstruction, functional gastrointestinal disorders, drugs, psychosocial issues and malnutrition). It gives management guidelines for patients with an enteric myopathy or neuropathy including the use of enteral and paren...
2 CitationsSource
#1Dipesh H. Vasant (University of Manchester)H-Index: 10
#2Loris Pironi (UNIBO: University of Bologna)H-Index: 37
Last. Simon Lal (University of Manchester)H-Index: 33
view all 13 authors...
BACKGROUND Chronic intestinal pseudo-obstruction (CIPO) and enteric dysmotility (ED) are small intestinal motility disorders defined by radiological and manometric criteria. In the absence of consensus guidelines, we surveyed opinions on the diagnosis and management of CIPO and ED among experts from different countries. METHODS A survey questionnaire was circulated electronically to members of the European society for Clinical Nutrition and Metabolism, European Society of Neurogastroenterology a...
2 CitationsSource
#1Dipesh H. VasantH-Index: 10
#2Loris PironiH-Index: 37
Last. Simon LalH-Index: 33
view all 12 authors...
Introduction Severe gastrointestinal dysmotility (GID) can be sub-classified into Chronic Intestinal Pseudo-obstruction (CIPO) and Enteric Dysmotility (ED) subtypes. We surveyed current opinions on the diagnosis and management of GID amongst experts from different countries. Methods An survey questionnaire developed by the European society for Clinical Nutrition and Metabolism (ESPEN) was circulated electronically to members of ESPEN, European Society of Neurogastroenterology and Motility, and U...
#1Peter Paine (University of Salford)H-Index: 15
#1P Paine (University of Salford)H-Index: 2
Abstract Centrally mediated abdominal pain and the associated narcotic bowel syndrome are functional bowel disorders that are challenging to manage and associated with significant medical harm, including unnecessary investigations, opioids and surgeries. They are distinguished from more common conditions, such as irritable bowel syndrome, by the near-continuous nature of the pain, irrespective of gastrointestinal physiological functioning. Their pathophysiology is obscure and incompletely unders...
1 CitationsSource
#1Eleesia Kilgallon (Salford Royal NHS Foundation Trust)H-Index: 1
#2Dipesh H. Vasant (University of Manchester)H-Index: 10
Last. Peter Paine (University of Manchester)H-Index: 15
view all 7 authors...
BACKGROUND: Chronic continuous abdominal pain (CCAP) is characteristic of centrally mediated gastrointestinal pain disorders. It consumes significant healthcare resources yet is poorly understood, with minimal cohort-specific data in the literature. AIMS: To examine in a large cohort of CCAP patients, (a) diagnostic features, (b) iatrogenic impact of opioids and surgery, (c) drug treatment effects and tolerance. METHODS: Consecutive tertiary CCAP referrals to a neurogastroenterology clinic (2009...
5 CitationsSource
#1Dipesh H. Vasant (Salford Royal NHS Foundation Trust)H-Index: 10
#2Ramya Kalaiselvan (Salford Royal NHS Foundation Trust)H-Index: 3
Last. Simon Lal (University of Manchester)H-Index: 33
view all 9 authors...
Summary Background & aims Severe gastrointestinal dysmotility (GID) is a significant cause of chronic intestinal failure (CIF) with unclear benefits of sub-classifying into Chronic Intestinal Pseudo-obstruction (CIPO) and non-CIPO sub-types. We compared outcomes between CIPO and non-CIPO sub-types in a tertiary cohort of patients with CIF resulting from severe GID. Methods Adults with primary GID, commenced on home parenteral nutrition (HPN) over a 16-year period at a national referral centre, w...
8 CitationsSource