Rita Hahn
Rutgers University
AnatomyOphthalmologyInternal medicineEndocrinologyGenetically modified mouseSurgeryPathologyMolecular biologyGap junctionAndrologyChemistryCorneaNitrogen mustardUmbilical arteryWound healingSulfur mustardCorneal InjuryFetal growthSkin woundCollagen fibrilCancer researchEpitheliumMedicineBiologyCell biology
25Publications
3H-index
107Citations
Publications 25
Newest
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#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Donald R. Gerecke (RU: Rutgers University)H-Index: 18
Last. Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
view all 6 authors...
1 CitationsSource
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Rita Hahn (RU: Rutgers University)H-Index: 3
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 5 authors...
Purpose: Organ cultures of rabbit corneas have been used to ascertain the effectiveness of a human fibroblast growth factor (FGF)-1 derivative (TTHX1114), lacking cysteine residues, to protect against and/or repair epithelial lesions following exposure to nitrogen mustard (NM). Methods: Rabbit corneas were exposed to NM and cultured for up to 14 days, with or without drug (TTHX1114). At specified times, tissue was examined by histopathology and graded by a novel composite scale. Proliferation wa...
4 CitationsSource
#1Yoke-Chen ChangH-Index: 7
#2Hui-Ying ChangH-Index: 2
Last. Donald R. GereckeH-Index: 18
view all 6 authors...
Sulfur mustard (SM) and its analog nitrogen mustard (NM) are potent bifunctional alkylating agents that induce skin blisters. They crosslink proteins and DNA and alter cell adhesion of basement membrane molecules. Dermal toxicity of the mustard agents includes separation of the epidermis and dermis, a strong inflammatory response, and prolonged wound healing. Matricellular proteins (MPs) including SPARC and hevin (aka SPARC-like 1) are secreted proteins that are incorporated into the provisional...
1 Citations
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Andrea DeSantis-Rodrigues (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 7 authors...
Mustard exposures result in epithelial-stromal separations in the cornea and epidermal-dermal separations in the skin. Large blisters often manifest in skin, while the cornea develops microblisters, and, when enough form, the epithelium sloughs. If the exposure is severe, healing can be imperfect and can result in long-term adverse consequences. For the cornea, this could manifest as recurrent corneal erosions. Since the corneal epithelial-stromal separations are in the region identified by elec...
9 CitationsSource
#1Marion K. GordonH-Index: 21
Last. Kathy K.H. Svoboda (A&M: Texas A&M University)H-Index: 25
view all 8 authors...
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#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2Hui-Ying Chang (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 7 authors...
Connexin 43 (Cx43) antisense treatment accelerates diabetic skin wound repair. Cx43 expression and its phosphorylation (pCx43) alters gap junction communication during skin wound repair. Vesicant induced skin injury results in prolonged wound healing similar to diabetic wounds. We performed a time course study using Cx43 antisense oligodeoxynucleotides (asODN) on nitrogen mustard (NM) injured SKH-1 hairless mouse dorsal skin to evaluate wound progression and Cx expression. Immunofluorescent (IF)...
1 CitationsSource
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Andrea DeSantis Rodrigues (RU: Rutgers University)
Last. Kathy K.H. Svoboda (A&M: Texas A&M University)H-Index: 25
view all 6 authors...
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Jae Yoon Jeon (RU: Rutgers University)
Last. Francesco Ramirez (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 86
view all 6 authors...
Fibrillar collagens give integrity and tensile strength to many organs in the body. Collagen XXIV is a non-traditional collagen in the fibrillar collagen family. To determine what its function might be in bone, collagen XXIV knock out (KO) mice were analyzed. Since femurs of null mice at 3 and 5 months of age were found to be osteoporotic compared to WT mice, our goal was to quantify mRNAs involved in regulation of bone deposition and resorption, and determine whether the loss of collagen XXIV a...
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