Xiaowen Jiang
Shenyang Pharmaceutical University
PhosphorylationThermogenesisChemistryApoptosisAutophagyLipid dropletNeuroprotectionCassiaCaffeoylquinic acidOxidative stressWestern blotCinnamaldehydeCinnamomumAntioxidantHyperphosphorylationWortmanninSH-SY5YNeurotoxicityBrown adipose tissueArctium lappaCytochrome cBiochemistrySignal transductionNMDA receptorMedicineProtein kinase BPI3K/AKT/mTOR pathwayCell biologyPharmacology
15Publications
7H-index
102Citations
Publications 16
Newest
#1Qiong Wu (SPU: Shenyang Pharmaceutical University)H-Index: 5
#2Tian-Yi Liu (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Huai-Wei Ding (SPU: Shenyang Pharmaceutical University)H-Index: 7
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Hepatocellular carcinoma (HCC) is an aggressive tumor with a poor prognosis that highly expresses phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (ERK). The PI3K/AKT/mTOR and MAPK/ERK signaling pathways play a crucial role in HCC tumor formation, cell cycle, apoptosis and survival. However, no effective targeted therapies against these pathways is available, mainly due to the extensive and complex negative feedback loops between them. Here we used CK-3, a dual blocker o...
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Abstract null null Alzheimer’s disease (AD) is a chronic and progressive neurodegenerative disease, characterized by irreversible cognitive impairment, memory loss and behavioral disturbances, ultimately leading to death. Glycogen synthase kinase 3β (GSK-3β) and dual-specificity tyrosine phosphorylation regulated kinase1A (DYRK1A) have gained a lot of attention for its role in tau pathology. To search for potential dual GSK-3β/DYRK1A inhibitors, we focused on harmine, a natural β-carboline alkal...
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#1Xiang-Li (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Bo-Xing (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract Background Cinnamomum cassia (L.) J.Presl (Cinnamon) was known as a kind of hot herb, improved circulation and warmed the body. However, the active components and mechanisms of dispelling cold remain unknown. Methods The effects of several Chinses herbs on thermogenesis were evaluated on body temperature and activation of brown adipose tissue. After confirming the effect, the components of cinnamon were identified using HPLC-Q-TOF/MS and screened with databases. The targets of component...
2 CitationsSource
#1Yue YangH-Index: 5
#2Huan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract Background Arctium lappa L. roots are very popular cultivated vegetables, which possesses various pharmacological activities. Our previous studies have demonstrated that Arctium lappa L. roots exerted protective effects against H2O2, glutamate and N-methyl-D-aspartic acid (NMDA)-induced neuronal injury in vitro. However, whether Arctium lappa L. roots could prevent against cerebral ischemia and the underlying mechanism remain unclear. Purpose The objective of the present study was to in...
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#1Xiang Li (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Hong-yuan Lu (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract Ethnopharmacological relevance Cinnamomum cassia (L.) J.Presl (Lauraceae), a widely used traditional Chinese medicine, is well known to exert hot property. It is recorded as dispelling cold drug in ancient Chinese monographs, such as Synopsis of golden chamber published in Han dynasty. According to Chinese Pharmacopoeia (2015), Cinnamomum cassia (L.) J.Presl (Cinnamon) has the functions of dispersing cold, relieving pain, warming meridians and promoting blood circulation. Aim of the stu...
4 CitationsSource
#2Xiaowen Jiang (SPU: Shenyang Pharmaceutical University)H-Index: 7
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Abstract Objective Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra (SN). Our previous study demonstrated kukoamine A (KuA) to exhibit strong neuroprotective effects through antioxidative stress, and autophagy in MPTP/MPP+-induced PD models in vivo and in vitro. It is necessary to evaluate the efficacy of the anti-PD effects under various models. Methods In the present study, total chemical synthesis was used to obtain KuA, which performed low con...
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#1Yue Yang (SPU: Shenyang Pharmaceutical University)H-Index: 5
#2Ling-Yue Gao (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Kukoamine (KuA) is a spermine alkaloid present in traditional Chinese medicine Cortex Lycii radices, which possesses various pharmacological properties. Our previous studies have demonstrated that KuA exerts neuroprotective effects against H2O2-induced oxidative stress, radiation-induced neuroinflammation, oxidative stress and neuronal apoptosis, as well as neurotoxin-induced Parkinson's disease through apoptosis inhibition and autophagy enhancement. The present study aimed to investigate the ne...
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#1Yue Yang (SPU: Shenyang Pharmaceutical University)H-Index: 5
#2Huan GaoH-Index: 2
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
view all 10 authors...
: Compound DCMQA (4, 5-O-dicaffeoyl-1-O-[4-malic acid methyl ester]-quinic acid) is a natural caffeoylquinic acid derivative isolated from Arctium lappa L. roots. Caffeoylquinic acid derivatives have been reported to possess neuroprotective effects through inhibiting oxidative stress and apoptosis in vitro. However, whether DCMQA exerts protective effects on N-methyl-D-aspartate (NMDA)-induced neurotoxicity and the underlying mechanism has not been elucidated. In this study, the results indicate...
3 CitationsSource
#1Huan GaoH-Index: 2
#2Xiaowen Jiang (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Qing-Chun ZhaoH-Index: 3
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Abstract Five undescribed caffeoylquinic acid derivatives (CQAs), along with fifteen known CQAs, were isolated from the roots of Arctium lappa L.(burdock). The chemical structures of compounds were determined using extensive spectroscopic analyses, including UV, IR, NMR and MS. Further in vitro bioactive investigation demonstrated the neuroprotective effects of these compounds against the neurotoxicity of hydrogen peroxide (H2O2) and N-methyl-D-aspartate (NMDA). 1,3,5-tri-O-caffeoylquinic acid a...
6 CitationsSource
#1Wenwu Liu (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Xiaowen Jiang (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
view all 9 authors...
Abstract l -glutamate is an excitatory neurotransmitter in the central nervous system (CNS), which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N-methyl-D-aspartate (NMDA) receptor is a ligand-gated ion channel belonging to the iGluRs family. Among NMDA receptor subtypes, GluN2B subtype plays a crucial role in CNS diseases. In this review, we summarize, classify and discuss the reports on GluN2B antagonists, published from the 1990s to 2020, to provide the ther...
6 CitationsSource