Linlin Li
Fujian Medical University
Univariate analysisRenal functionTumor necrosis factor alphaChemistryMultiple myelomaWestern blotInflammasomeBortezomibNF-?BImmune complexCytokineLupus nephritisKidneyCreatinineIcariinTransfectionMedicineInterleukinGastroenterologyKlotho
Publications 3
#1Xuduan Chen (Fujian Medical University)H-Index: 2
#2Xiaofeng Luo (Fujian Medical University)H-Index: 6
Last. Lixin Wei (Fujian Medical University)
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BACKGROUND Renal impairment (RI) is associated with poor survival in newly diagnosed multiple myeloma (MM) patients. Renal function recovery has been one of the main therapeutic goals in those patients. METHODS The records from 393 newly diagnosed MM patients in our hospital between January 2012 and December 2016 were retrospectively analyzed. RI was defined as an eGFR < 40 mL/min according to the novel IMWG criteria. RI patients were categorized based on their renal function at diagnosis: sever...
#1Hong Ye (Fujian Medical University)H-Index: 2
#2Bofeng Su (First Affiliated Hospital of Wenzhou Medical University)H-Index: 2
Last. Huidi Zhang (First Affiliated Hospital of Wenzhou Medical University)H-Index: 1
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Abstract Klotho is considered to have renal protective effect by prohibiting the activation of the nuclear factor (NF)-κB pathway, while the role of microRNA-199a (miR-199a)/Klotho in lupus nephritis (LN) is still unknown. A single dose of pristane (0.5 ml) was intraperitoneally injected into 8 weeks-old female mice to establish the LN model. MiR-199a mimic or miR-199a inhibitor, Klotho plasmid or Klotho siRNA, and miR-199a inhibitor plus si-Klotho were transfected into lipopolysaccharides (LPS)...
9 CitationsSource
#1Bofeng Su (First Affiliated Hospital of Wenzhou Medical University)H-Index: 2
#2Hong Ye (Fujian Medical University)H-Index: 2
Last. Linlin Li (Fujian Medical University)H-Index: 2
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Abstract Aims Lupus nephritis (LN) is a kidney inflammatory disease caused by systemic lupus erythematosus (SLE). Both NF-κB activation and NLRP3 inflammasome activation are implicated in LN pathogenesis, suggesting they are potential targets for LN treatment. Icariin, which is isolated from Chinese medicine Horny Goat Weed (Ying Yang Huo), has been shown to have anti-inflammation activity, and inhibit activations of both NF-κB and NLRP3 inflammasome. In present study, the effects of icariin on ...
17 CitationsSource