Luyao Wang
Sichuan University
Targeted drug deliveryLiposomeChemistryMaterials scienceIn vitroIn vivoProstateChemotherapyPaclitaxelMelanomaMetastasisInsulinParkinson's diseaseDrug deliveryDrugProstate cancerSubstantia nigraTargeted therapyDoxorubicinToxicityErythrocyte membraneInsulin deliveryIntravenous glucoseCancer researchDopamineBreast cancerDiabetes mellitusMedicinePharmacologyDistribution (pharmacology)
14Publications
9H-index
237Citations
Publications 15
Newest
Abstract null null Current clinical agents for autoimmunity disorders treatment often cause substantial adverse effects and safety concerns, owing to non-specific immune modulation. Due to the prominent contribution of effector T cells in pathogenesis of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), and preferential location of co-stimulatory receptor-ligand pair OX40-OX40L at the inflamed sites, selectively targeting autoaggressive T cells by blockade OX40-OX40L, might represe...
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#1Shiqi Huang (Sichuan University)H-Index: 4
#2Lang Deng (Sichuan University)H-Index: 3
Last. Ling Zhang (Sichuan University)H-Index: 9
view all 10 authors...
Melanoma is a highly aggressive cancer which often forms metastatic tumors in the lung, leading to sharply reduced patients’ survival rate. Effectively treating these tumors thus could improve late stage melanoma with lung metastasis. In this study, we fabricated a Cys-Arg-Glu-Lys-Ala with N-methylated Glu (CR(NMe)EKA) decorated disk shaped nano vehicle to co-deliver tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and paclitaxel (PTX) to lung melanoma tumor sites (TRAIL-[ND-PTX]C...
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#1Bingjie Zhou (Sichuan University)H-Index: 2
#2Min Li (Sichuan University)
Last. Shiqi Huang (Sichuan University)H-Index: 4
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Breast cancer was the leading cause of newly diagnosed cases of tumors in 2020, ranking as the second highest cause of female death. Chemotherapy remains the conventional treatment of choice for breast tumors in most clinical cases. However, it is often accompanied by a poor prognosis and severe side effects, resulting from an insufficient accumulation of the drug at tumor sites and an unsystematic distribution of the drug across the body. Inspired by the fact that breast tumor cells overexpress...
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#1Shiqi Huang (Sichuan University)H-Index: 4
#2Yicong Zhang (Sichuan University)H-Index: 1
Last. Ling Zhang (Sichuan University)H-Index: 9
view all 11 authors...
Abstract Malignant melanoma, a highly dangerous type of skin cancer, is usually resistant to pro-apoptosis agents such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) due to low death receptor expression levels. After verifying combination of chemotherapy drug paclitaxel (PTX) and TRAIL could significantly enhance their anti-melanoma effects, we developed a liposomal melanoma target-delivery system with tumor microenvironment responsiveness (TRAIL-[Lip-PTX]C18-TR) to co-delive...
10 CitationsSource
#1Qing Lin (University of Cambridge)H-Index: 2
#2Mengke Qu (Sichuan University)H-Index: 7
Last. Zhirong Zhang (Sichuan University)H-Index: 63
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Abstract Ethnopharmacological relevance Bulbus Fritillaria cirrhosa D. Don (BFC) is a Chinese traditional herbal medicine that has long been used as an indispensable component in herbal prescriptions for bronchopulmonary diseases due to its well-established strong anti-inflammation and pulmonary harmonizing effects. Interestingly, there are few case reports in traditional Chinese medicine available where they found it to contribute in anti-tumor therapies. Imperialine is one of the most favored ...
7 CitationsSource
#1Luyao Wang (Sichuan University)H-Index: 9
#2Bingjie Zhou (Sichuan University)H-Index: 2
Last. Ling Zhang (Sichuan University)H-Index: 9
view all 11 authors...
Currently, prostate cancer is the most frequently diagnosed cancer in males and chemotherapy is often essential for treating advanced prostate cancer. However, common chemotherapies for prostate cancer suffer from serious adverse effects due to poor drug targeting ability and tissue penetration, even with the help of conventional drug delivery systems. Here, encouraged by recent studies showing possible drug retention and tissue penetration advantages of unconventional non-spherical nanoparticle...
8 CitationsSource
Though plastic nanoparticles have already raised much concern for their potential impact on health, our understanding of their biological effects is still utterly limited. Here we demonstrate for the first time that carboxyl-modified polystyrene nanoparticles (CPS) could effectively inhibit ferroptosis as a result of reduced cellular ROS which was triggered by transcription factor EB (TFEB) nucleus translocation. In this process, CPS first entered cells via macropinocytosis, then CPS-containing ...
23 CitationsSource
#1Mengke Qu (Sichuan University)H-Index: 7
#2Qing Lin (Sichuan University)H-Index: 11
Last. Xun Sun (Sichuan University)H-Index: 50
view all 11 authors...
Abstract Parkinson's disease (PD), one of the most common movement and neurodegenerative disorders, is challenging to treat, largely because the blood-brain barrier blocks passage of most drugs. Here we find exosomes from blood showing natural brain targeting ability which involved the transferrin-transferrin receptor interaction. Thus, we develop a biocompatible platform based on blood exosomes for delivering drugs across the blood-brain barrier. Blood exosomes show sizes between 40 and 200 nm ...
114 CitationsSource
#1Yu Fu (Sichuan University)H-Index: 7
#2Wei Liu (Sichuan University)H-Index: 3
Last. Ling Zhang (Sichuan University)H-Index: 9
view all 11 authors...
29 CitationsSource
#1Yu Fu (Sichuan University)H-Index: 7
#2Wei Liu (Sichuan University)H-Index: 3
Last. Ling Zhang (Sichuan University)H-Index: 9
view all 11 authors...
1 CitationsSource