Vahid H. Gazestani
University of California, San Diego
GeneCancerData miningPhenotypeWnt signaling pathwaySystems biologyTranscriptomeRegulation of gene expressionNeuroscienceAutismAutism spectrum disorderDiseaseTrypanosoma bruceiProstate cancerBiological networkPopulationComputer scienceGeneticsGene regulatory networkRNAComputational biologyMedicinePI3K/AKT/mTOR pathwayBiology
30Publications
10H-index
381Citations
Publications 29
Newest
#1Michael V. Lombardo (IIT: Istituto Italiano di Tecnologia)H-Index: 56
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 16 authors...
Cortical regionalization develops via genomic patterning along anterior-posterior (A-P) and dorsal-ventral (D-V) gradients. Here we find that normative A-P and D-V genomic patterning of cortical surface area (SA) and thickness (CT) present in typically developing and autistic toddlers with good early language outcome, is absent in autistic toddlers with poor early language outcome. Autistic toddlers with poor early language outcome are instead specifically characterized by secondary and independ...
1 CitationsSource
#1Michael V. Lombardo (IIT: Istituto Italiano di Tecnologia)H-Index: 56
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Natasha Bertelsen (IIT: Istituto Italiano di Tecnologia)H-Index: 1
view all 0 authors...
Cortical regionalization develops via genomic patterning along anterior-posterior (A-P) and dorsal-ventral (D-V) gradients. Here we find that normative A-P and D-V genomic patterning of cortical surface area (SA) and thickness (CT) present in typically developing and autistic toddlers with good early language outcome, is absent in autistic toddlers with poor early language outcome. Autistic toddlers with poor early language outcome are instead specifically characterized by secondary and independ...
1 CitationsSource
#1Karen Pierce (UCSD: University of California, San Diego)H-Index: 51
#2Vahid H. Gazestani (UCSD: University of California, San Diego)H-Index: 10
view all 15 authors...
Objectives To examine the impact of a new approach, Get SET Early, on the rates of early autism spectrum disorder (ASD) detection and factors that influence the screen-evaluate-treat chain. Study design Following Get SET Early training, 203 pediatricians administered 57,603 total screens using the Communication and Symbolic Behavior Scales Infant-Toddler Checklist at 12, 18, and 24-month well-baby examinations, and parents designated presence or absence of concern. For screen-positive toddlers, ...
Source
#1Michael V. Lombardo (IIT: Istituto Italiano di Tecnologia)H-Index: 56
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 16 authors...
Cortical regional identities develop through anterior-posterior (A-P) and dorsal-ventral (D-V) prenatal genomic patterning gradients. Here we find that A-P and D-V genomic patterning of cortical surface area (SA) and thickness (CT) is intact in typically developing and autistic toddlers with good language outcome, but is absent in autistic toddlers with poor early language outcome. Genes driving this effect are prominent in midgestational A-P and D-V gene expression gradients and prenatal cell t...
1 CitationsSource
#1Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
#2Vahid H. Gazestani (UCSD: University of California, San Diego)H-Index: 10
Last. Nathan E. Lewis (UCSD: University of California, San Diego)H-Index: 44
view all 3 authors...
Autism spectrum disorder (ASD) is a largely heritable, multistage prenatal disorder that impacts a child’s ability to perceive and react to social information. Most ASD risk genes are expressed prenatally in many ASD-relevant brain regions and fall into two categories: broadly expressed regulatory genes that are expressed in the brain and other organs, and brain-specific genes. In trimesters one to three (Epoch-1), one set of broadly expressed (the majority) and brain-specific risk genes disrupt...
18 CitationsSource
#1Benjamin P. Kellman (University of California, Berkeley)H-Index: 11
#2Hratch M. Baghdassarian (University of California, Berkeley)H-Index: 4
Last. Nathan E. Lewis (University of California, Berkeley)H-Index: 44
view all 13 authors...
RNA-Seq is ubiquitous, but depending on the biological question or the sample source, some RNA-Seq collection methods require variable or sub-optimal sample handling. Rare tissue may need to be fixed or frozen prior to library preparation, or samples may remain at room temperature while other samples or reagents are handled. These challenges create uncharacterized impacts on sample quality. Understanding the relevant experimental factors that impact sample quality is crucial to ensuring reproduc...
1 CitationsSource
#1Wan-Tien Chiang (UCSD: University of California, San Diego)
#2Vahid H. Gazestani (UCSD: University of California, San Diego)H-Index: 10
Last. Nathan E. Lewis (UCSD: University of California, San Diego)H-Index: 44
view all 17 authors...
Source
#1Eric Fombonne (OHSU: Oregon Health & Science University)H-Index: 109
#2Robin P. Goin-Kochel (BCM: Baylor College of Medicine)H-Index: 28
Last. Allyson ZickH-Index: 1
view all 304 authors...
Abstract Background Fear of autism has led to a decline in childhood-immunization uptake and to a resurgence of preventable infectious diseases. Identifying characteristics of parents who believe in a causal role of vaccines for autism spectrum disorder (ASD) in their child may help targeting educational activities and improve adherence to the immunization schedule. Objectives To compare caregivers of children with ASD who agree or disagree that vaccines play an etiological role in autism for 1)...
5 CitationsSource
#1Vahid H. Gazestani (UCSD: University of California, San Diego)H-Index: 10
#2Tiziano Pramparo (UCSD: University of California, San Diego)H-Index: 31
Last. Nathan E. LewisH-Index: 44
view all 9 authors...
Hundreds of genes are implicated in autism spectrum disorder (ASD), but the mechanisms through which they contribute to ASD pathophysiology remain elusive. Here we analyzed leukocyte transcriptomics from 1- to 4-year-old male toddlers with ASD or typical development from the general population. We discovered a perturbed gene network that includes highly expressed genes during fetal brain development. This network is dysregulated in human induced pluripotent stem cell-derived neuron models of ASD...
21 CitationsSource
#1Vahid H. Gazestani (UCSD: University of California, San Diego)H-Index: 10
#2Tiziano Pramparo (UCSD: University of California, San Diego)H-Index: 31
Last. Nathan E. LewisH-Index: 44
view all 9 authors...
ABSTRACT Hundreds of genes are implicated in autism spectrum disorder (ASD) but the mechanisms through which they contribute to ASD pathophysiology remain elusive. Here, we analyzed leukocyte transcriptomics from 1-4 year-old male toddlers with ASD or typical development from the general population. We discovered a perturbed gene network that includes genes that are highly expressed during fetal brain development and which is dysregulated in hiPSC-derived neuron models of ASD. High-confidence AS...
1 CitationsSource