Xavier Golay
University College London
Internal medicineRadiologyPerfusion scanningPathologyMagnetic resonance imagingPerfusionArtificial intelligenceCerebral blood flowCardiologyNeuroscienceChemistryHypothermiaGrey matterNeonatal encephalopathyMultiple sclerosisWhite matterNuclear medicineComputer scienceAnesthesiaNuclear magnetic resonanceMedicine
344Publications
60H-index
11.2kCitations
Publications 327
Newest
#2Flora A. Kennedy McConnell (University of Nottingham)H-Index: 2
Abstract null null The mismatch in the spatial resolution of Arterial Spin Labeling (ASL) MRI perfusion images and the anatomy of functionally distinct tissues in the brain leads to a partial volume effect (PVE), which in turn confounds the estimation of perfusion to a specific tissue of interest such as grey or white matter. This confound occurs because the image voxels contain a mixture of tissues with disparate perfusion properties, leading to estimated perfusion values that reflect primarily...
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#1Nicola J. Robertson (UCL: University College London)H-Index: 52
#2Christopher Meehan (UCL: University College London)H-Index: 5
Last. Mark W. Lowdell (Royal Free London NHS Foundation Trust)H-Index: 48
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Abstract Background: With therapeutic hypothermia (HT) for neonatal encephalopathy, disability rates are reduced, but not all babies benefit. Pre-clinical rodent studies suggest mesenchymal stromal cells (MSCs) augment HT protection. Aims:The authors studied the efficacy of intravenous (IV) or intranasal (IN) human umbilical cord-derived MSCs (huMSCs) as adjunct therapy to HT in a piglet model. Methods:A total of 17 newborn piglets underwent transient cerebral hypoxia-ischemia (HI) and were then...
1 CitationsSource
#1Kathryn A Martinello (University of Adelaide)H-Index: 8
#2Christopher Meehan (UCL: University College London)H-Index: 5
Last. Nicola J. Robertson (UCL: University College London)H-Index: 52
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BACKGROUND Perinatal inflammation combined with hypoxia-ischemia (HI) exacerbates injury in the developing brain. Therapeutic hypothermia (HT) is standard care for neonatal encephalopathy; however, its benefit in inflammation-sensitized HI (IS-HI) is unknown. METHODS Twelve newborn piglets received a 2 µg/kg bolus and 1 µg/kg/h infusion over 52 h of Escherichia coli lipopolysaccharide (LPS). HI was induced 4 h after LPS bolus. After HI, piglets were randomized to HT (33.5 °C 1-25 h after HI, n =...
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#1Raymand Pang (UCL: University College London)H-Index: 2
#2Adnan Advic-Belltheus (UCL: University College London)
Last. Nicola J. Robertson (UCL: University College London)H-Index: 52
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Neonatal encephalopathy is a leading cause of morbidity and mortality worldwide. Although therapeutic hypothermia (HT) is now standard practice in most neonatal intensive care units in high resource settings, some infants still develop long-term adverse neurological sequelae. In low resource settings, HT may not be safe or efficacious. Therefore, additional neuroprotective interventions are urgently needed. Melatonin’s diverse neuroprotective properties include antioxidant, anti-inflammatory, an...
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#1Alvaro Rojas-Villabona (RVI: Royal Victoria Infirmary)H-Index: 3
#2Magdalena Sokolska (UCL: University College London)H-Index: 13
Last. Hans Rolf Jäger (UCL: University College London)H-Index: 47
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Purpose Intra-arterial Digital Subtraction Angiography (DSA) is the gold standard technique for radiosurgery target delineation in brain Arterio-Venous Malformations (AVMs). This study aims to evaluate whether a combination of three Magnetic Resonance Angiography sequences (triple-MRA) could be used for delineation of brain AVMs for Gamma Knife Radiosurgery (GKR). Methods Fifteen patients undergoing DSA for GKR targeting of brain AVMs also underwent triple-MRA: 4D Arterial Spin Labelling based a...
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#1Alvaro Rojas-Villabona (RVI: Royal Victoria Infirmary)H-Index: 3
Last. HR JagerH-Index: 7
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BACKGROUND AND PURPOSE Intra-arterial DSA has been traditionally used for confirmation of cure following gamma knife radiosurgery for AVMs. Our aim was to evaluate whether 4D arterial spin-labeling MRA and contrast-enhanced time-resolved MRA in combination can be an alternative to DSA for confirmation of AVM obliteration following gamma knife radiosurgery. MATERIALS AND METHODS In this prospective study, 30 patients undergoing DSA for confirmation of obliteration following gamma knife radiosurge...
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#1Ingran Lingam (UCL: University College London)H-Index: 6
#2Adnan Avdic-Belltheus (UCL: University College London)H-Index: 6
Last. Nicola J. Robertson (UCL: University College London)H-Index: 52
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Exposure to inflammation exacerbates injury in neonatal encephalopathy (NE). We hypothesized that brain biomarker mRNA, cytokine mRNA and microRNA differentiate inflammation (E. coli LPS), hypoxia (Hypoxia), and inflammation-sensitized hypoxia (LPS + Hypoxia) in an NE piglet model. Sixteen piglets were randomized: (i) LPS 2 μg/kg bolus; 1 μg/kg infusion (LPS; n = 5), (ii) Saline with hypoxia (Hypoxia; n = 6), (iii) LPS commencing 4 h pre-hypoxia (LPS + Hypoxia; n = 5). Total RNA was acquired at ...
1 CitationsSource
#1Smriti Patodia (UCL Institute of Neurology)H-Index: 3
#1Smriti PatodiaH-Index: 4
Last. Maria ThomH-Index: 69
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AIMS Sudden unexpected death in epilepsy (SUDEP) likely arises as a result of autonomic dysfunction around the time of a seizure. In vivo MRI studies report volume reduction in the medulla and other brainstem autonomic regions. Our aim, in a pathology series, is to correlate regional quantitative features on 9.4T MRI with pathology measures in medullary regions. METHODS 47 medullae from 18 SUDEP, 18 non-epilepsy controls (NEC) and 11 epilepsy controls (EPC) were studied. In 16 cases, representin...
2 CitationsSource
#1Smriti Patodia (UCL Institute of Neurology)H-Index: 3
#1Smriti PatodiaH-Index: 4
Last. Maria ThomH-Index: 69
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We are grateful to Dr Finsterer and colleagues for the important points raised on our study which also highlight more general issues in conducting neuropathological research in SUDEP. The SUDEP cases were mainly community deaths in domestic settings, with post-mortem investigations falling under the jurisdiction of the Coroner and local pathology services. In the UK, the Royal college of Pathologists has provided guidance for the methodological approaches to these post-mortem examinations since ...
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#1Laure Fournier (University of Paris)H-Index: 26
#2Lena Costaridou (University of Patras)H-Index: 21
Last. Nandita M deSouza (European Society of Radiology)
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Existing quantitative imaging biomarkers (QIBs) are associated with known biological tissue characteristics and follow a well-understood path of technical, biological and clinical validation before incorporation into clinical trials. In radiomics, novel data-driven processes extract numerous visually imperceptible statistical features from the imaging data with no a priori assumptions on their correlation with biological processes. The selection of relevant features (radiomic signature) and inco...
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